Peripartum cardiomyopathy with a history of doxorubicin therapy: case report & review of literature

Background: Peripartum cardiomyopathy and doxorubicin-induced cardiomyopathy are well described conditions but there is little description in the literature of both occurring together. Case: A 29 year old G1P0 with a remote history of childhood chondroblastic osteosarcoma treated with high-dose doxorubicin therapy who developed minimally symptomatic cardiomyopathy during her pregnancy with ejection fraction reaching as low as 20-30%. She delivered via primary low-transverse cesarean section at 37 weeks complicated by uterine atony with an unremarkable recovery. Cardiomyopathy was treated with metoprolol and enalapril and she achieved ejection fraction of 44% at one year follow-up with complete return to baseline activity. Discussion: We present a woman with a history of doxorubicin therapy who developed peripartum cardiomyopathy and recovered symptomatically after one year. Although treatment of peripartum cardiomyopathy regardless of etiology is well-defined, there are few reports and no standard guidelines for special considerations in pregnant women with a history of doxorubicin therapy, a topic that may warrant further investigation

Peripartum cardiomyopathy with a history of doxorubicin therapy: case report & review of literature

Background: Peripartum cardiomyopathy and doxorubicin-induced cardiomyopathy are well described conditions but there is little description in the literature of both occurring together. Case: A 29 year old G1P0 with a remote history of childhood chondroblastic osteosarcoma treated with high-dose doxorubicin therapy who developed minimally symptomatic cardiomyopathy during her pregnancy with ejection fraction reaching as low as 20-30%. She delivered via primary low-transverse cesarean section at 37 weeks complicated by uterine atony with an unremarkable recovery. Cardiomyopathy was treated with metoprolol and enalapril and she achieved ejection fraction of 44% at one year follow-up with complete return to baseline activity. Discussion: We present a woman with a history of doxorubicin therapy who developed peripartum cardiomyopathy and recovered symptomatically after one year. Although treatment of peripartum cardiomyopathy regardless of etiology is well-defined, there are few reports and no standard guidelines for special considerations in pregnant women with a history of doxorubicin therapy, a topic that may warrant further investigation

Integrated Alternative Source of Energy System with Grid Substation

This paper discusses the modeling, simulation and optimization of integrated alternative source of energy system with grid substation. When there is a lack of energy in grid substation to meet the demand of customer load then alternative source of energy compensates energy deficiency and after that if there is excess energy available then remaining energy is stored in battery bank or sells to grid according to need. In another case when required energy is not generated by alternative sources then remaining energy is purchased from the grid and if the grid substation hasn't available these remaining energy to meet the customer load demand during the peak load then stored battery energy is also active. The size of integrated alternative source of energy system may vary from few hundred watts to ten or hundreds of MW. The possible sources of alternative energy like solar, wind and biomass are considered under this paper. Study location, Muzaffarpur district of Bihar (India), is taken because there is good potential of energy generation from alternative source of energy and still there is no any wind and solar energy power plant. The modeling and simulation of the system is done by using HOMER software and the software solve the optimization problem to minimize the total cost of system and maximum utilization of alternative source of energy

Understanding tradeoffs in incremental deployment of new network architectures

Despite the plethora of incremental deployment mechanisms proposed, rapid adoption of new network-layer protocols and architectures remains difficult as reflected by the widespread lack of IPv6 traffic on the Internet. We show that all de-ployment mechanisms must address four key questions: How to select an egress from the source network, how to select an ingress into the destination network, how to reach that egress, and how to reach that ingress. By creating a de-sign space that maps all existing mechanisms by how they answer these questions, we identify the lack of existing mech-anisms in part of this design space and propose two novel approaches: the “4ID ” and the “Smart 4ID”. The 4ID mech-anism utilizes new data plane technology to flexibly decide when to encapsulate packets at forwarding time. The Smart 4ID mechanism additionally adopts an SDN-style control plane to intelligently pick ingress/egress pairs based on a wider view of the local network. We implement these mech-anisms along with two widely used IPv6 deployment mech-anisms and conduct wide-area deployment experiments over PlanetLab. We conclude that Smart 4ID provide better overall performance and failure semantics, and that inno-vations in the data plane and control plane enable straight-forward incremental deployment

Combined local-density and dynamical mean field theory calculations for the compressed lanthanides Ce, Pr, and Nd

This paper reports calculations for compressed Ce (4f^1), Pr (4f^2), and Nd (4f^3) using a combination of the local-density approximation (LDA) and dynamical mean field theory (DMFT), or LDA+DMFT. The 4f moment, spectra, and the total energy among other properties are examined as functions of volume and atomic number for an assumed face-centered cubic (fcc) structure.Comment: 15 pages, 9 figure

Amino­guanidinium hydrogen succinate

The title compound, CH7N4 +·C4H5O4 −, is a molecular salt containing discrete amino­guanidinium and succinate ions. The amino­guanidinium cation is nearly planar, with a maximum deviation of 0.035 (1) Å. The dihedral angle between the amino­guanidinium cation and the succinate anion is 3.35 (6)°. The crystal packing exhibits inter­molecular N—H⋯O and O—H⋯·O hydrogen bonds

Classifying multi-level stress responses from brain cortical EEG in Nurses and Non-health professionals using Machine Learning Auto Encoder

ObjectiveMental stress is a major problem in our society and has become an area of interest for many psychiatric researchers. One primary research focus area is the identification of bio-markers that not only identify stress but also predict the conditions (or tasks) that cause stress. Electroencephalograms (EEGs) have been used for a long time to study and identify bio-markers. While these bio-markers have successfully predicted stress in EEG studies for binary conditions, their performance is suboptimal for multiple conditions of stress.MethodsTo overcome this challenge, we propose using latent based representations of the bio-markers, which have been shown to significantly improve EEG performance compared to traditional bio-markers alone. We evaluated three commonly used EEG based bio-markers for stress, the brain load index (BLI), the spectral power values of EEG frequency bands (alpha, beta and theta), and the relative gamma (RG), with their respective latent representations using four commonly used classifiers.ResultsThe results show that spectral power value based bio-markers had a high performance with an accuracy of 83%, while the respective latent representations had an accuracy of 91%

Nanosecond Ultrasonics to Study Phase Transitions in Solid and Liquid Systems at High Pressure and Temperature

This report describes the development of a high-frequency ultrasonic measurement capability for application to the study of phase transitions at elevated pressure and temperature. We combined expertise in various aspects of static high-pressure technique with recent advances in wave propagation modeling, ultrasonic transducer development, electronic methods and broadband instrumentation to accomplish the goals of this project. The transduction and electronic systems have a demonstrated bandwidth of 400 MHz, allowing investigations of phenomena with characteristic times as short as 2.5 nS. A compact, pneumatically driven moissanite anvil cell was developed and constructed for this project. This device generates a high-pressure environment for mm dimension samples to pressures of 3 GPa. Ultrasonic measurements were conducted in the moissanite cell, an LLNL multi-anvil device and in a modified piston cylinder device. Measurements for water, and elemental tantalum, tin and cerium demonstrate the success of the methods. The {gamma}-{alpha} phase transition in cerium was clearly detected at {approx}0.7 GPa with 75 MHz longitudinal waves. These results have direct application to important problems in LLNL programs, as well as seismology and planetary science

X-ray diffraction studies using diamond coated rhenium gasket to megabar pressures

X-ray diffraction studies at megabar pressures are limited by the sample thickness between the diamond anvils. High strength gaskets are desirable to improve the quality of x-ray diffraction data. We present a technique which employs a microwave plasma chemical vapor deposited diamond layer on one side of a rhenium gasket. As a test case, we show energy dispersive x-ray diffraction data on rare earth metal neodymium to 153 GPa using a synchrotron source. The increased sample thickness results in an unambiguous crystal structure determination of a monoclinic phase in neodymium above 75 GPa. [chemical vapor deposition, diamond, rhenium gasket, x-ray diffraction, neodymium