37 research outputs found
The persistence of self-employment across borders: new evidence on legal immigrants to the United States
Using recently-available data from the New Immigrant Survey, we find that previous self-employment experience in an immigrant’s country of origin is an important
determinant of their self-employment status in the U.S., increasing the probability of being self-employed by about 7 percent. Our results improve on the previous literature by measuring home-country self-employment directly rather than relying on proxy measures. We find little evidence to suggest that home-country self employment has a significant effect on U.S. wages in either paid employment or self employment
Wealth, Health, and Child Development: Evidence from Administrative Data on Swedish Lottery Players
Equalizing Outcomes vs. Equalizing Opportunities: Optimal Taxation When Children's Abilities Depend on Parents' Resources
Higher Education for California Native Nation Building: A Retrospective on College Experience and Completion
A Distinctive Structural Twist in the Aminoimidazole Alkaloids from a Calcareous Marine Sponge: Isolation and Characterization of Leucosolenamines A and B
NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening
The
US National Cancer Institute’s (NCI) Natural Product
Repository is one of the world’s largest, most diverse collections
of natural products containing over 230,000 unique extracts derived
from plant, marine, and microbial organisms that have been collected
from biodiverse regions throughout the world. Importantly, this national
resource is available to the research community for the screening
of extracts and the isolation of bioactive natural products. However,
despite the success of natural products in drug discovery, compatibility
issues that make extracts challenging for liquid handling systems,
extended timelines that complicate natural product-based drug discovery
efforts and the presence of pan-assay interfering compounds have reduced
enthusiasm for the high-throughput screening (HTS) of crude natural
product extract libraries in targeted assay systems. To address these
limitations, the NCI Program for Natural Product Discovery (NPNPD),
a newly launched, national program to advance natural product discovery
technologies and facilitate the discovery of structurally defined,
validated lead molecules ready for translation will create a prefractionated
library from over 125,000 natural product extracts with the aim of
producing a publicly-accessible, HTS-amenable library of >1,000,000
fractions. This library, representing perhaps the largest accumulation
of natural-product based fractions in the world, will be made available
free of charge in 384-well plates for screening against all disease
states in an effort to reinvigorate natural product-based drug discovery