Factors Affecting Readiness for Business Process Reengineering-Developing and Proposing a Conceptual Model

In this paper researcher made an effort to suggest an approach to minimize risk of implementing Business Process Reengineering (BPR) initiatives by identifying certain factors crucial towards creating readiness for BPR. Lack of readiness is main factor behind high rate of BPR failures. Extensive literature review and interviews from the panel of experts provided sufficient background information. Leadership style, Information technology (IT), Top management commitment and collaborative working figured out as critical factors towards creating readiness. Regular leadership actions consistent with organizational environment, collaborative working, Information Technology and Top management commitment could promote coherence in organizational members' readiness perceptions. Assessing BPR readiness can address strong points, weak points and risks, and hence the ranking/level of readiness in the organization. Keywords: Business process reengineering, Business process readiness, Critical success factors, Organizational change

Work life conflict impact on Female’s Job performance. A study of primary level female school teachers in Pakistan

The study is focused on impact of work life conflict on job performance of female school teachers while keeping organization policy as a moderating variable. Data was collected from 200 female school teachers of different schools using questionnaires. Result showed that Work life conflict has a negative impact on job performance of female employees and Organization policies do not moderate this relationship. The results are analysed using Regression and other statistical tests to check that whether organization policies contribute to reduce work life pressure and stress or not. The research proved that improvement is desired in improving organization policies to enhance female teachers’ performance and increase their motivation reducing work life pressure and strain. Keywords: Work Life conflict, Job performance, Organization Policy, Education sector, Pakistan, female teachers, private school

Ellagic Acid Suppresses the Oxidative Stress Induced by Dietary-Oxidized Tallow

Dietary tallow was thermally oxidized at 180°C in an open fryer. The oxidized tallow (OT) and unoxidized tallow were characterized for oxidation parameters and fatty acid composition using GC-MS. Tallow samples were fed to rabbits along with 50, 100, and 150 mg/kg/day of ellagic acid (EA) for three weeks. Results revealed that the peroxide value (PV) and thiobarbituric acid reactive substances (TBARS) significantly increased, while radical scavenging activity (RSA) of the tallow decreased significantly with oxidation. GC-MS analysis showed eight fatty acids in the tallow samples, where palmitic acid (48.5-49.7 g/100 g), linoleic acid (18.7-23.7 g/100 g), stearic acid (13.5-15.6 g/100 g), and margaric acid (6.32-6.42 g/100 g) were the major fatty acids. Animal studies showed that oxidized tallow (OT) alone or in combination with EA significantly altered the body weight of the rabbits. Serum biochemical parameters and renal function tests were affected by OT and ameliorated by EA. The toxic effects of OT on haematological indices were minimized by EA. The supplementation of OT alone had significant effects on the liver structure and functions. The coadministration of EA reduced the toxic properties of OT on the liver, by increasing the antioxidant (GSH) system. The rabbit heart was also affected by the OT, which was ameliorated by EA supplementation. These results suggested that the supplementation of EA was beneficial against the OT-induced oxidative stress and may be considered for foods containing oxidized lipids

Molecular Mechanisms and Regulation of Mammalian Mitophagy

Mitochondria in the cell are the center for energy production, essential biomolecule synthesis, and cell fate determination. Moreover, the mitochondrial functional versatility enables cells to adapt to the changes in cellular environment and various stresses. In the process of discharging its cellular duties, mitochondria face multiple types of challenges, such as oxidative stress, protein-related challenges (import, folding, and degradation) and mitochondrial DNA damage. They mitigate all these challenges with robust quality control mechanisms which include antioxidant defenses, proteostasis systems (chaperones and proteases) and mitochondrial biogenesis. Failure of these quality control mechanisms leaves mitochondria as terminally damaged, which then have to be promptly cleared from the cells before they become a threat to cell survival. Such damaged mitochondria are degraded by a selective form of autophagy called mitophagy. Rigorous research in the field has identified multiple types of mitophagy processes based on targeting signals on damaged or superfluous mitochondria. In this review, we provide an in-depth overview of mammalian mitophagy and its importance in human health and diseases. We also attempted to highlight the future area of investigation in the field of mitophagy

A Research study on 92 News Religious program “Subha-e- Noor”

Subah Noor is one of the Islamic program aired on the 92 news, a popular TV channel in Pakistan. The number of viewers of this program are more than one billion on YouTube which testifies to its popularity. Various Islamic scholars are invited in this program who discuss the selected topic in the light of Quran and Sunnah. In this article, a critical review has been offered whether the information disseminated among the public is correct or not. All sahih and Daeef Hadees that came under discussion in this program have been separately analysed to verify the authenticity of the content

Negative feedback system to maintain cell ROS homeostasis: KEAP1-PGAM5 complex senses mitochondrially generated ROS to induce mitophagy

International audienceIf cellular reactive oxygen species (ROS) production surpasses the intracellular antioxidant capacity, thus altering the ROS homeostasis, the cell needs to eradicate faulty mitochondria responsible for these excessive ROS. We have shown that even moderate ROS production breaks the KEAP1-PGAM5 complex, inhibiting the proteasomal removal of PGAM5. This leads to an accumulation of PGAM5 interfering with PINK1 processing that sensitizes mitochondria to autophagic removal. We propose that such a negative feedback system maintains cell ROS homeostasis

Clinical results from spine operations and expert interviews a multi center study

Objective: This study aims to assess the short-term clinical results of spine procedures performed in a QHAMC, Nowshera, Pakistan. Methods: This study was conducted in orthopedic unit and neurosurgery unit of a QHAMC, Nowshera in Pakistan where this single-center investigation was carried out. The phrase "short-term clinical outcome" was used in this research to refer to the results of spine procedures within one week of the surgery. These results were broken down into three categories: Recovery, complications, and deaths. This particular research looked at a total of 208 different instances. In these patients, procedures such as Fenestration and discectomies, laminectomy, anterior cervical discectomies, and transpedicular fixations were performed. Results: Recovery was shown in terms of the muscle power restored in the limbs according to MRC scale criteria at the time of discharging each patient.&nbsp