IN SILICO APPROACH TARGETING POLYPHENOL AS FABH INHIBITOR IN BACTERIAL INFECTION

Objective: The aim of the study is to perform a computational study consisting of molecular docking for polyphenols subjected to in silico studies to identify a new lead for antimicrobial activity which has been reported yet or not been used yet. Methods: The Schrödinger Maestro 11.3 performed molecular docking of the enzyme FabH (β-ketoacyl-acyl carrier protein synthase III) (PDB ID: 5BNR) with polyphenol. The targeted compounds were docked against FabH enzyme and also evaluated for MM-GBSA and ADMET analysis. Results: The top hits shows remarkable results and good binding interactions with a pocket of the enzyme. The best binding score are as-8.6 (kcal/mol) of Geniestein,-8.579 (kcal/mol) of 4-naphthoquinone,-7.651(kcal/mol) of Pelargonidin. All the targeted compounds were found in the given limits of ADMET parameters. They also showed good free-binding energy. Conclusion: The computational study reveals that the targeted polyphenols show good binding interactions and are also compatible with ADMET parameters. So, with this, we can conclude that the reported polyphenols can be potent against bacterial infection. In the future, if we derivatized these polyphenols with different substitutions, it can also lead to a potential drug moiety against bacterial infection

Multi-Language based Android Application for Motor Control

some wise individual once aforementioned that system could be a system wherever we will finish off the machine whenever we'd like. That’s the distinction between controlled and uncontrolled system. Our project is regarding create this system economical and dynamic. Because the name instructed the automated management is for dominant the motor from remote place, look over its operational conditions; get feedback from the motor itself. Our target is to manage the motor from distant place by mobile DTMF tone and conjointly get feedback by SMS whereas it's in ON or OFF condition. We tend to conjointly make sure the safe operation of the motor by police investigation the voltage of the supply and guarantee feedback from system whereas it's over or below voltage. Once more we tend to conjointly get these feedbacks by SMS additionally. GSM network is all over in our country that’s why we decide GSM network to control our motor conjointly transferring feedback data through it. We tend to conjointly use GSM network as a result of if we tend to use it then we tend to don’t have to be compelled to establish further instrumentation for networking. To transmit feedback signals we tend to use GSM electronic equipment at the motor finish conjointly generate management signal by mobile DTMF as a result of it's terribly simple to get DTMF by mobile station and send feedback SMS by electronic equipment additionally. In industrial sector we tend to hope our project is become handy and value effective to control motor and provides its protection

Faulty feeding practices in children less than 2 years of age and their association with nutritional status: A study from a rural medical college in Central India

Background: Undernutrition has a direct correlation with the prevailing feeding practices. Early years are crucial in determining the rate and extent of growth and mainly depend on the level of nutrition and care provided. The first episode of growth faltering occurs mostly in children <2 years of age that often goes unnoticed. Objective: The objective of this study was to explore the faulty feeding practices, their determinants, and association with nutritional status in children <2 years of age. Materials and Methods: This cross-sectional study using mixed (qualitative and quantitative) methods was conducted in a sample of 187 mothers and their children at the mother and child health (MCH) clinic of a rural medical college. Results: Only 144 (77%) of the study children had received colostrum. 47 (25.1%) of the mothers had used prelacteal feeds. Although breastfeeding (BF) was universal, only 133 (71.1%) of the mothers were exclusively breastfeeding (EBF) their children. The duration of each feed was an issue; in 49 (32.4%) of the children, the duration of each feed was <10 min with almost all the mothers swapping the baby to other breast during one episode of feeding. Not giving colostrum, not giving EBF, duration of feeds <10 min, swapping the breasts during each feed, and decreased frequency of feeding during illness were found to be significantly associated with poor nutritional status. Conclusion: In our study, we found out that although practice of BF was universal, there is definite scope for further improving the practices. A definite gap between knowledge and practice was observed, which was associated with adverse nutritional outcomes

Rebleeding in aneurysm after rectal enema: Re‐emphasis on careful subarachnoid hemorrhage management

Abstract Rebleeding in an aneurysmal subarachnoid hemorrhage (SAH) is catastrophic with high mortality and grave outcome. Meticulous management of SAH patients and the prevention of activities that might increase the chances of rebleeding are life‐saving

QuantMAC: Enhancing Hardware Performance in DNNs With Quantize Enabled Multiply-Accumulate Unit

In response to the escalating demand for hardware-efficient Deep Neural Network (DNN) architectures, we present a novel quantize-enabled multiply-accumulate (MAC) unit. Our methodology employs a right shift-and-add computation for MAC operation, enabling runtime truncation without additional hardware. This architecture optimally utilizes hardware resources, enhancing throughput performance while reducing computational complexity through bit-truncation techniques. Our key methodology involves designing a hardware-efficient MAC computational algorithm that supports both iterative and pipeline implementations, catering to diverse hardware efficiency or enhanced throughput requirements in accelerators. Additionally, we introduce a processing element (PE) with a pre-loading bias scheme, reducing one clock delay and eliminating the need for conventional extra resources in PE implementation. The PE facilitates quantization-based MAC calculations through an efficient bit-truncation method, removing the necessity for extra hardware logic. This versatile PE accommodates variable bit-precision with a dynamic fraction part within the sfxpt&#x003C; N,f > representation, meeting specific model or layer demands. Through software emulation, our proposed approach demonstrates minimal accuracy loss, revealing under 1.6&#x0025; loss for LeNet-5 using MNIST and around 4&#x0025; for ResNet-18 and VGG-16 with CIFAR-10 in the sfxpt&#x003C; 8 ,5 > format compared to conventional float32-based implementations. Hardware performance parameters on the Xilinx-Virtex-7 board unveil a 37&#x0025; reduction in area utilization and a 45&#x0025; reduction in power consumption compared to the best state-of-the-art MAC architecture. Extending the proposed MAC to a LeNet DNN model results in a 42&#x0025; reduction in resource requirements and a significant 27&#x0025; reduction in delay. This architecture provides notable advantages for resource-efficient, high-throughput edge-AI applications

A Rare Presentation of Orbital Castleman’s Disease

Castleman’s disease (CD) is an uncommon group of atypical lymphoproliferative disorders. Extranodal involvement such as the orbit is extremely rare. We aim to report a case of a 62-year-old male who presented with left painless proptosis for the past three years. Examination revealed a firm, lobulated mass in the left superotemporal orbit, displacing the globe inferomedially. A well-defined extraconal orbital lesion encasing the left lateral rectus muscle with intraconal extension was seen on Magnetic Resonance Imaging (MRI) that led to the provisional diagnosis of left solitary encapsulated venous malformation. Excision of the mass via lateral orbitotomy was performed. However, on histopathology, the features were consistent with a mixed-cell variant of Castleman’s disease. A detailed systemic workup was unremarkable. Proptosis resolved after surgery and no recurrence was noted in the three-year follow-up. To the best of our knowledge, this is the first case report of a mixed-cell variant of unicentric orbital CD without any systemic features. This case highlights the importance of including CD in the differential diagnosis of well-defined orbital lesions so as to enable its early detection and timely management

Clinical Presentation and Management Strategies in Intraorbital Foreign Bodies

The authors present a retrospective, observational case study of seven patients, who presented with retained Intra-Orbital Foreign Bodies (IOrbFBs) following penetrating orbital injury at a tertiary eye hospital over a period of one year. Cases were reviewed for epidemiological features, mechanism of injury, nature of foreign body, clinical features, imaging modality, associated complications, management outcomes, and the final prognosis. The mean age of presentation was 27.43 years. Amongst the seven patients, two were children (aged <10 years). The male : female ratio was 4 : 3. Of the seven retained IOrbFBs, two were plastic, two wooden, and three metallic in nature (one gunshot injury, one ball projectile (commonly referred to as BB) injury, and one with knife). Two out of seven had no light perception at presentation. The periocular location of the foreign bodies was inferior in 4 cases and medial in 3 cases. Computed Tomography scan confirmed the diagnosis in five cases and Magnetic Resonance Imaging (MRI) was diagnostic in one. Surgical intervention was done in five cases, and two cases were managed conservatively. The authors conclude that favourable outcome can be achieved even without surgical removal in cases of inert metallic/inorganic IOrbFBs. The properties of plastic FBs can frequently render them invisible on imaging, or they may mimic chronic inflammatory conditions like tuberculosis. Long-standing wooden IOrbFBs evade identification radiologically due to prolonged hydration. The ultimate choice of intervention must be individualised, weighing the risks of retention against the risk of iatrogenic damage

Book of Abstracts of the 2nd International Conference on Applied Mathematics and Computational Sciences (ICAMCS-2022)

It is a great privilege for us to present the abstract book of ICAMCS-2022 to the authors and the delegates of the event. We hope that you will find it useful, valuable, aspiring, and inspiring. This book is a record of abstracts of the keynote talks, invited talks, and papers presented by the participants, which indicates the progress and state of development in research at the time of writing the research article. It is an invaluable asset to all researchers. The book provides a permanent record of this asset. Conference Title: 2nd International Conference on Applied Mathematics and Computational SciencesConference Acronym: ICAMCS-2022Conference Date: 12-14 October 2022Conference Organizers: DIT University, Dehradun, IndiaConference Mode: Online (Virtual

Abstracts of National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020

This book presents the abstracts of the papers presented to the Online National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020 (RDMPMC-2020) held on 26th and 27th August 2020 organized by the Department of Metallurgical and Materials Science in Association with the Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, India. Conference Title: National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020Conference Acronym: RDMPMC-2020Conference Date: 26–27 August 2020Conference Location: Online (Virtual Mode)Conference Organizer: Department of Metallurgical and Materials Engineering, National Institute of Technology JamshedpurCo-organizer: Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, IndiaConference Sponsor: TEQIP-