Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery

<p>Abstract</p> <p>Background</p> <p>Emerging perioperative genomics may influence the direction of risk assessment and surgical strategies in cardiac surgery. The aim of this study was to investigate whether single nucleotide polymorphisms (SNP) affect the clinical presentation and predispose to increased risk for postoperative adverse events in patients undergoing coronary artery bypass grafting surgery (CABG).</p> <p>Methods</p> <p>A total of 220 patients undergoing first-time CABG between January 2005 and May 2008 were screened for factor V gene G1691A (FVL), prothrombin/factor II G20210A (PT G20210A), angiotensin I-converting enzyme insertion/deletion (ACE-ins/del) polymorphisms by PCR and Real Time PCR. End points were defined as death, myocardial infarction, stroke, postoperative bleeding, respiratory and renal insufficiency and event-free survival. Patients were compared to assess for any independent association between genotypes for thrombosis and postoperative phenotypes.</p> <p>Results</p> <p>Among 220 patients, the prevalence of the heterozygous FVL mutation was 10.9% (n = 24), and 3.6% (n = 8) were heterozygous carriers of the PT G20210A mutation. Genotype distribution of ACE-ins/del was 16.6%, 51.9%, and 31.5% in genotypes I/I, I/D, and D/D, respectively. FVL and PT G20210A mutations were associated with higher prevalence of totally occluded coronary arteries (p < 0.001). Furthermore the risk of left ventricular aneurysm formation was significantly higher in FVL heterozygote group compared to FVL G1691G (<it>p </it>= 0.002). ACE D/D genotype was associated with hypertension (<it>p </it>= 0.004), peripheral vascular disease (p = 0.006), and previous myocardial infarction (<it>p </it>= 0.007).</p> <p>Conclusions</p> <p>FVL and PT G20210A genotypes had a higher prevalence of totally occluded vessels potentially as a result of atherothrombotic events. However, none of the genotypes investigated were independently associated with mortality.</p

Measurement of the CP-violating phase phi(s) from B-s(0) -&gt; J/psi pi(+)pi(-) decays in 13 TeV pp collisions

Decays of B-s(0) and (B) over bar (0)(s) mesons into J/psi pi(+)pi(-) final states are studied in a data sample corresponding to 1.9 fb(-1) of integrated luminosity collected with the LHCb detector in 13 TeV pp collisions. A time-dependent amplitude analysis is used to determine the final-state resonance contributions, the CP-violating phase phi(s) = -0.057 +/- 0.060 +/- 0.011 rad, the decay-width difference between the heavier mass B-s(0) eigenstate and the B-0 meson of -0.050 +/- 0.004 +/- 0.004 ps(-1), and the CP-violating parameter vertical bar lambda vertical bar = 1.01(-0.06)(+0.08) +/- 0.03, where the first uncertainty is statistical and the second systematic. These results are combined with previous LHCb measurements in the same decay channel using 7 TeV and 8 TeV pp collisions obtaining phi(s) = 0.002 +/- 0.044 +/- 0.012 rad, and vertical bar lambda vertical bar = 0.949 +/- 0.036 +/- 0.019. (C) 2019 The Author. Published by Elsevier B.V