Incorporation of lipid nanosystems containing omega‑3 fatty acids and resveratrol in textile substrates for wound healing and anti‑inflammatory applications

In the present work, lipid nanosystems containing omega-3 fatty acid (nanostructured lipid carriers, NLCs) or omega-3 fatty acid and resveratrol (liposomes) were developed to improve cotton textile substrates as dressings with anti-inflammatory properties for wound healing applications. Lipid nanosystems were incorporated into woven, non-woven and knitted cotton substrates by exhaustion and impregnation. Based on physical–chemical characterization of the textile substrates, the textile structure and type of lipid nanosystems dictated the adsorption efficiency. In the case of NLCs, the woven substrate functionalized by exhaustion had a higher omega-3 release being the most promising for wound dressing application. Whereas for liposomes, the most adequate textile was the cationized knitted fabric functionalized by impregnation, that showed a more prolonged release profile of resveratrol.This work is financed by Project UID/CTM/00264/2019 of 2C2T - Centro de Ciencia e Tecnologia Textil, funded by National Founds through FCT/MCTES. The authors also acknowledge the Portuguese Foundation for Science and Technology (FCT) for financial support in the framework of the Strategic Funding UID/Multi/04546/2013 and UID/FIS/04650/2019 in the ambit of the project POCI-01-0145-FEDER-032651, co-financed by the European Regional Development Fund (ERDF), through COMPETE 2020, under Portugal 2020

Virchow’s node: a case report of an extremely rare presentation of metastasis of adenocarcinoma with mucinous features from the colon

Mohamed S Suliman,1 Monider Singh,1 Aman Naim Ajmeri,1 David L Stuart,2 Samson T Teka11Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, 25701, USA; 2Department of Surgery, Beckley Appalachian Regional Hospital, Beckley, WV, 25801, USAAbstract: Colon cancer is one of the most common causes of cancer-related mortality. Adenocarcinoma with mucinous features accounts for 10–15% of colon carcinoma. Distal nodal metastatic colorectal cancer is uncommon, and metastasis of colorectal cancer to the left supraclavicular lymph node is extremely rare without signs of metastatic organ involvement. We present a case of a 54-year-old Caucasian male with colonic adenocarcinoma that presented initially as a left-sided neck mass that had progressively increased in size over 9 months. On physical exam, a left supraclavicular soft tissue mass 6 cm in diameter was appreciated, it was non-tender with no submandibular lymphadenopathy. Soft tissue mass was palpable on the anterior abdominal wall in the epigastric region. Open excisional tissue biopsy of the left supraclavicular mass revealed metastatic adenocarcinoma with mucinous features and colonoscopy revealed a 6 cm obstructing mass in the transverse colon with biopsy revealing primary adenocarcinoma of the mucinous type. Palliative care with comfort measures was agreed upon. Typically, the most common sites of colon cancer metastasis are regional lymph nodes, liver, lung, bone and brain, and ours demonstrated an extremely rare pattern of colon cancer metastasis. The presentation to metastasize to the left supraclavicular node without solid end organ involvement makes this case even more novel.Keywords: Virchow’s node, adenocarcinoma with mucinous features from the colon, skip micrometastases, colon cancer, case repor

Varicella Zoster aseptic meningitis: Report of an atypical case in an immunocompetent patient treated with oral valacyclovir

Varicella Zoster when described has the typical presentation of a dermatomal distribution of a rash and can further lead to CNS complications. This can be treated accordingly with the proper protocol, but if the presentation is atypical and the protocol is challenged or changed per specific patient outcomes, new developments can occur. Here we present a case of a 29-year-old Caucasian female that presented to the emergency department with headache, photophobia, and chills for 5 days. She was previously healthy and immunocompetent; CSF PCR analysis revealed a VZV infection causing acute aseptic meningitis with no shingles rash eruption on physical examination. The patient was not willing to stay hospitalized for the duration of the treatment. This gave us an opportunity to treat her with an oral, rather than IV, antiviral. The patient was successfully treated with oral valacyclovir 2 g Q6H after only receiving two days of IV acyclovir. To the best of our knowledge, this is the first reported case of a patient with VZV-associated meningitis successfully treated with oral valacyclovir. Keywords: Aseptic meningitis, Varicella Zoster virus, Oral valacyclovir, Atypical meningitis, Immunocompetent, Cranial nerve deficit

Toward a rational and ethical sociotechnical system of autonomous vehicles: A novel application of multi-criteria decision analysis

The expansion of artificial intelligence (AI) and autonomous systems has shown the potential to generate enormous social good while also raising serious ethical and safety concerns. AI technology is increasingly adopted in transportation. A survey of various in-vehicle technologies found that approximately 64% of the respondents used a smartphone application to assist with their travel. The top-used applications were navigation and real-time traffic information systems. Among those who used smartphones during their commutes, the top-used applications were navigation and entertainment. There is a pressing need to address relevant social concerns to allow for the development of systems of intelligent agents that are informed and cognizant of ethical standards. Doing so will facilitate the responsible integration of these systems in society. To this end, we have applied Multi-Criteria Decision Analysis (MCDA) to develop a formal Multi-Attribute Impact Assessment (MAIA) questionnaire for examining the social and ethical issues associated with the uptake of AI. We have focused on the domain of autonomous vehicles (AVs) because of their imminent expansion. However, AVs could serve as a stand-in for any domain where intelligent, autonomous agents interact with humans, either on an individual level (e.g., pedestrians, passengers) or a societal level