Differential susceptibility of catheter biomaterials to biofilm-associated infections and their remedy by drug-encapsulated Eudragit RL100 nanoparticles

Biofilms are the cause of major bacteriological infections in patients. The complex architecture of Escherichia coli (E. coli) biofilm attached to the surface of catheters has been studied and found to depend on the biomaterial’s surface properties. The SEM micrographs and water contact angle analysis have revealed that the nature of the surface a ects the growth and extent of E. coli biofilm formation. In vitro studies have revealed that the Gram-negative E. coli adherence to implanted biomaterials takes place in accordance with hydrophobicity, i.e., latex > silicone > polyurethane > stainless steel. Permanent removal of E. coli biofilm requires 50 to 200 times more gentamicin sulfate (G-S) than the minimum inhibitory concentration (MIC) to remove 90% of E. coli biofilm (MBIC90). Here, in vitro eradication of biofilm-associated infection on biomaterials has been done by Eudragit RL100 encapsulated gentamicin sulfate (E-G-S) nanoparticle of range 140 nm. It is 10–20 times more e ective against E. coli biofilm-associated infections eradication than normal unentrapped G-S. Thus, Eudragit RL100 mediated drug delivery system provides a promising way to reduce the cost of treatment with a higher drug therapeutic index

Terminalia catappa Linn.: A TREASURY OF PHARMACOLOGICAL BENEFITS

Terminalia catappa Linn. belonging to family Combretaceae is well known plant due to its nutritional fruit, bark, leaves and roots which are having medicinal properties. The various phytochemicals which are present in it are such as gallic acid, ellagic acid, corilagin, alkaloid, flavonoid, protein, phytosteroids, phenol and carotenoids are isolated form the different parts of the plant in various solvent systems. These isolated compounds have found to be possess numerous pharmacological properties such as antioxidant, antidiabetic, antimicrobial, antifungal,  antinociceptive, hepatitis treatment, hypocholesterolemia, immunomodulatory, anthelmintic, antiviral, antiaging, anti-inflammatory, anticancer, anti-tumor, hematological, anthelmintic, aphrodisiac, wound healing. These all pharmacological activities cumulatively enhanced its traditional value and uses. In this review paper, the different pharmacological activities and their benefits are explored which are exhibited by different phytoconstituents present in different parts of the plant

BIOLOGICAL ACTIVITY OF RICE STRAW-DERIVED MATERIALS: AN OVERVIEW

RS (RS) waste has been the most widely recognised pollutant in the world for several years. Therefore, it is critical to develop a simple process for converting rice straw (RS) into a useful products.  RS is a rich source of phenolic acids (PAs), lignin, condensed tannins, flavonoids, and momilactone that can be extracted using conventional and environmentally friendly methods. These bioactive components of RS have various biological activities such as antibacterial, antifungal, pesticide, antioxidant, etc. Recently, RS-derived fluorescent nitrogen-doped carbon dots (NCDs) were developed for the detection and monitoring of diabetic ketoacidosis in diabetic patients. Herein, various straightforward and non-polluting method for reprocessing RS into value-added materials are discussed

Ciprofloxacin HCl and quercetin functionalized electrospun nanofiber membrane : fabrication and its evaluation in full thickness wound healing

Microbial infection and oxidative damage of the fibroblast often results in prolonged and incomplete wound healing. Therefore, there is an increasing demand for a scaffold being effective to prevent any possible infection and neutralize excessively released free radicals. Herein, we designed a PCL-based nanofiber loaded with ciprofloxacin hydrochloride (CHL) and quercetin. Developed nanofiber showed the formation of smooth and continuous nanofiber with 101.59 ± 29.18 nm average diameter and entrapping the drugs in amorphous form without any possible physico-chemical interaction between drugs and excipient. High entrapment efficiency (CHL: 92.04% and Que: 94.32%) and prolonged in-vitro release (for 7 days) demonstrated the capability of scaffold to suppress any probable infection and oxidative damage, which was further confirmed by in-vitro antibacterial and antioxidant activity. The biocompatibility of scaffold for direct application to wound site was evaluated through hemocompatibility and cytocompatibility assay. The wound healing efficacies of nanofiber were assessed using full thickness wound model in rats, which displayed accelerated wound healing with complete re-epithelialization and improved collagen deposition within 16 days. In-vivo wound healing finding was further corroborated by SOD, catalase, and hydroxyproline assay. The current study validates the application of ciprofloxacin HCl and quercetin functionalized nanofiber as a potential wound dressing material.Published versio