<b>Synthesis, characterization, antiplasmodial and antitrypanosomal activity of some metal(III) complexes of sulfadiazine</b>

The Fe(III), Ru(III), Rh(III), and Cr(III) complexes of 4-amino-N-(2-pyrimidinyl)benzene sulfonamide (sulfadiazine) have been synthesized and characterized by elemental analysis, electronic and IR spectroscopy, conductance and room temperature magnetic susceptibility measurements. Sulfadiazine acts as a bidentate ligand through the sulfonamido and the pyrimidinic N-atoms. The compounds are non-electrolytes and the electronic spectra are consistent with the proposed octahedral geometry around the metal ions. The complexes were tested for <i>in vitro</i> activity against cultures of the resistant strains of <i>Plasmodium falciparum</i>, tripamastigotes <i>T. b. rhodesiense</i> and amastigotes <i>L. donovani</i> to determine their antiprotozoal activities. The Fe(III) complex is more active than the other complexes against the parasitic protozoa