Biosynthetic Origins of Menisporopsin A

Menisporopsin A, produced by <i>Menisporopsis theobromae,</i> shows antimalarial, antimycobacterial, and cytotoxic activities. Here, we report the first ¹³C incorporations at individual carbons of menisporopsin A using sodium [1-¹³C] and [2-¹³C] acetate. This result indicates that each of the subunits of the pentalactone menisporopsin A is assembled by a polyketide synthase