Numerative und Numerativkonstruktionen im Deutschen und im Chinesischen. Eine kontrastiv-typologische Untersuchung

This is a study in contrastive typology with reference to German and Chinese nouns and noun constructions. The comparison proceeds from the differences displayed by the two languages in connection with numeralization (combination of noun and numeral). In the framework of the apprehension dimension of the UNITYP approach, an attempt is first made to characterize the two languages as two different types, i.e. with numeral classification on the one hand as opposed to agreement in gender and number on the other. On this basis the numeratives and numerative constructions of the two languages are then described and compared from various perspectives. The numeratives are listed in relatively exhaustive catalogues and compared and contrasted in terms of word explanations and areas of use. The study is of interest for research into language typology and universals, as well as for practical language acquisition

Development of silk fibroin-derived nanofibrous drug delivery system in supercritical CO2

A silk fibroin (SF)-derived nanofibrous drug delivery system was fabricated by solution-enhanced dispersion via supercritical CO2 (SEDS) (20 MPa pressure, 8 mL/min flow rate, 35 °C temperature) in this study. Curcumin (CM) was used as a water-insoluble drug model. Nanofibrous structure with controllable fiber diameter (<100 nm) was obtained, and inter-molecular hydrogen bonds were formed between CM and SF; the crystallinity of the incorporated CM was remarkably decreased, which led to a significant enhancement in solubility of incorporated CM. In conclusion, SEDS could be developed to fabricate polymeric nanofibrous drug delivery system.Institute of Textiles and Clothin

Construction of a Novel Magnetic Targeting Anti-Tumor Drug Delivery System: Cytosine Arabinoside-Loaded Bacterial Magnetosome

To ease the side effects triggered by cytosine arabinoside (Ara-C) for acute leukemia treatment, a novel magnetic targeting anti-tumor drug delivery system was constructed through bacterial magnetosomes (BMs) from Magnetospirillum magneticum AMB-1 combined with Ara-C by crosslinking of genipin (GP). The results showed that Ara-C could be bonded onto the membrane surface of BMs effectively through chemical crosslinking induced by dual hand reagents GP. The average diameters of BMs and Ara-C-coupled BMs (ABMs) were 42.0 ± 8.6 and 72.7 ± 6.0 nm respectively, and the zeta potentials (−38.1 ± 9.1) revealed that these systems were stable, confirming the stability of the system. The optimal encapsulation efficiency and drug loading were 89.05% ± 2.33% and 47.05% ± 0.64% respectively when crosslinking reaction lasted for 72 h. The system also presented long-term stability and release behaviors without initial burst release (Ara-C could be released 80% within three months). Our results indicate that BMs have great potential in biomedical and clinical fields as a novel anti-tumor drug carrier