Selective oxidation of alcohols with a new reagent : iron(III) nitrate supported on aluminum silicate

A selective and effective oxidation of alcohols, except aliphatic alcohols, such as 1-hexanol or 1-octyl alcohol, to the corresponding aldehydes and ketones using a new reagent, iron(III) nitrate supported on aluminum silicate, under heterogeneous conditions with reflux with 85-98% yield is described

A first example of a reaction under viscous conditions : oxidation of solid benzoins with manganese dioxide

A new, general, and efficient technique for the reaction of solid substrates under viscous conditions with shaking at room temperature is described, which can overcome some of the problems existing in common solvent-free reactions solids as the starting materials. In this manuscript we present as a first example of this method the oxidation of solid benzoins into the corresponding benzils using an environmentally friendly and inexpensive oxidant, manganese dioxide

ChemInform Abstract: A First Example of a Reaction under Viscous Conditions: Oxidation of Solid Benzoins with Manganese Dioxide.

A new, general, and efficient technique for the reaction of solid substrates under viscous conditions with shaking at room temperature is described, which can overcome some of the problems existing in common solvent-free reactions solids as the starting materials. In this manuscript we present as a first example of this method the oxidation of solid benzoins into the corresponding benzils using an environmentally friendly and inexpensive oxidant, manganese dioxide

Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: Oxyradical overload diseases

Hemochromatosis and Wilson disease (WD), characterized by the excess hepatic deposition of iron and copper, respectively, produce oxidative stress and increase the risk of liver cancer. Because the frequency of p53 mutated alleles in nontumorous human tissue may be a biomarker of oxyradical damage and identify individuals at increased cancer risk, we have determined the frequency of p53 mutated alleles in nontumorous liver tissue from WD and hemochromatosis patients. When compared with the liver samples from normal controls, higher frequencies of G:C to T:A transversions at codon 249 (P < 0.001) and C:G to A:T transversions and C:G to T:A transitions at codon 250 (P < 0.001 and P < 0.005) were found in liver tissue from WD cases, and a higher frequency of G:C to T:A transversions at codon 249 (P < 0.05) also was found in liver tissue from hemochromatosis cases. Sixty percent of the WD and 28% of hemochromatosis cases also showed a higher expression of inducible nitric oxide synthase in the liver, which suggests nitric oxide as a source of increased oxidative stress. A high level of etheno-DNA adducts, formed from oxyradical-induced lipid peroxidation, in liver from WD and hemochromatosis patients has been reported previously. Therefore, we exposed a wild-type p53 TK-6 lymphoblastoid cell line to 4-hydroxynonenal, an unsaturated aldehyde involved in lipid peroxidation, and observed an increase in G to T transversions at p53 codon 249 (AGG to AGT). These results are consistent with the hypothesis that the generation of oxygen/nitrogen species and unsaturated aldehydes from iron and copper overload in hemochromatosis and WD causes mutations in the p53 tumor suppressor gene