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    Additional file 2: of rs10732516 polymorphism at the IGF2/H19 locus associates with genotype-specific effects on placental DNA methylation and birth weight of newborns conceived by assisted reproductive technology

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    Table S1. DNA methylation levels of H19 ICR (CTCF6), H19 DMR and LINE-1 in control and ART-derived placentas by EpiTYPER method. Methylation average values with SDs (±) of CpG units are presented. Gray boxes present significant methylation level difference at CpG sites in H19 DMR between ART and control samples within A/A genotype (nominal p-value < 0.05, Student’s t-test). Table S2. Total, rs10732516 genotype-specific (patG/matA and patA/matG) and allele-specific (paternal and maternal) DNA methylation levels at H19 ICR (CTCF6) in control and ART-derived placentas by traditional bisulfite sequencing. Gray boxes present significant methylation level difference at CpG sites between control and ART samples within genotypes and alleles (nominal p-value < 0.05, Mann-Whitney). Total methylation levels: total means of both genotypes and both alleles are included. Genotype-specific methylation levels: total means of both alleles are included. Allele-specific methylation levels: maternal and paternal alleles are presented separately. Table S3. rs10732516 patA/matG genotype- and allele-specific DNA methylation levels at H19 ICR1 (CTCF6) in controls and ART-derived newborns’ white blood cells (WBCs) in cord blood by traditional bisulfite sequencing. Genotype-specific methylation levels: total means of both alleles are included. Allele-specific methylation levels: maternal and paternal alleles are presented separately. (PDF 145 kb
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