Numerical optimisation of mechanical ring reinforcement for bulk high-temperature superconductors

The finite element method has been used extensively in recent years to solve various problems related to applied superconductivity and provides a useful tool for analysing and predicting experimental results. Based on a recently-developed modelling framework, implemented in the finite element software package COMSOL Multiphysics, investigations on the minimum ring reinforcement required to prevent mechanical failure in bulk high-temperature superconducting magnets have been carried out. Assuming homogeneous J$_{c}$(B,T) across the bulk sample irrespective of its dimensions, the maximum magnetic stresses experienced, and the minimum ring thickness required to prevent the hoop and radial stresses from exceeding the tensile strength of the bulk superconductor have been determined for varying values of the Young\u27s modulus, radius, height and temperature of a representative single-grain Ag-containing Gd-Ba-Cu-O bulk sample. This comprehensive analysis details the influence each of these key parameters has on the magnetic stress and hence their impact on the necessary ring thickness to prevent mechanical failure in any given system, i.e., for any combination of material properties and sample dimensions

Numerical optimisation of mechanical ring reinforcement for bulk high-temperature superconductors

Abstract: The finite element method has been used extensively in recent years to solve various problems related to applied superconductivity and provides a useful tool for analysing and predicting experimental results. Based on a recently-developed modelling framework, implemented in the finite element software package COMSOL Multiphysics, investigations on the minimum ring reinforcement required to prevent mechanical failure in bulk high-temperature superconducting magnets have been carried out. Assuming homogeneous Jc (B,T) across the bulk sample irrespective of its dimensions, the maximum magnetic stresses experienced, and the minimum ring thickness required to prevent the hoop and radial stresses from exceeding the tensile strength of the bulk superconductor have been determined for varying values of the Young’s modulus, radius, height and temperature of a representative single-grain Ag-containing Gd-Ba-Cu-O bulk sample. This comprehensive analysis details the influence each of these key parameters has on the magnetic stress and hence their impact on the necessary ring thickness to prevent mechanical failure in any given system, i.e., for any combination of material properties and sample dimensions

Saquinavir Loaded Acetalated Dextran Microconfetti – a Long Acting Protease Inhibitor Injectable

Since the adoption of highly active antiretroviral therapy, HIV disease progression has slowed across the world; however, patients are often required to take multiple medications daily of poorly bioavailable drugs via the oral route, leading to gastrointestinal irritation. Recently, long acting antiretroviral injectables that deliver drug for months at a time have moved into late phase clinical trials. Unfortunately, these solid phase crystal formulations have inherent drawbacks in potential dose dumping and a greater likelihood for burst release of drug compared to polymeric formulations

Numerical Simulation of High-Temperature Superconducting Stacked-Tape Magnetic Lens via H-ϕ Model

Magnetic lens, exploiting the induced screening current, may concentrate the spatial magnetic flux. This concept has been realized by several research groups using GdBCO and/or MgB₂ bulk superconductors. The limitation of the magnitude of concentrated flux density lies on the mechanical brittleness of the materials and the flux instability. High-temperature superconducting (HTS) tape possesses excellent mechanical and flux pinning properties and hence is a good candidate for magnetic lens. In this study, we implemented numerical simulations on the design of magnetic lenses using HTS stacked tapes. The models were constructed based on H-ϕ formulations. We investigated and compared the concentration effect of various magnetic lenses with different topologies. The results show that a central field of 22.69 T and 25.62 T can be achieved respectively with rectangular-shaped stacks and X-shaped stacks in an applied magnetic field of 20 T. An optimized design of the magnetic lens has been proposed and correspondingly the mechanism for a better concentration-effect has been explained which provides a good reference for future experiments and applications.National Key Research and Development Program (2016YFF0101701); Strategic Priority Research Program of Chinese Academy of Sciences (XDB25000000); Project (6140923050202); EPSRC Early Career Fellowship, EP/P020313/

Reliable 4.8 T trapped magnetic fields in Gd-Ba-Cu-O bulk superconductors using pulsed field magnetization

Abstract A robust and reliable in-situ magnetization method is essential for exploiting the outstanding magnetic flux trapping ability of bulk superconductors in practical applications. We report a 4.8 T peak trapped magnetic field, B T, achieved at 30 K in a 36 mm diameter GdBa2Cu3O7-δ –Ag bulk superconductor using pulsed field magnetization (PFM). To realize this, we have developed a reliable two-step multi-pulse PFM process based on understanding and exploiting the avalanche-like flux jump phenomenon observed in these materials. The magnitude of the applied pulsed magnetic field (B a) necessary to trap 4.8 T was merely 5.29 T, corresponding to a remarkable magnetization efficiency (B T/B a) of 90%.This study was supported by the Engineering and Physical Sciences Research Council (No. EP/P00962X/1), the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB25000000), the National Key R&D Program (2016YFF0101701) and the project (6140923050202). M D Ainslie would like to acknowledge financial support from an Engineering and Physical Sciences Research Council (EPSRC) Early Career Fellowship, EP/P020313/

A Trapped Field of 17.6 T in Melt-Processed, Bulk Gd-Ba-Cu-O Reinforced with Shrink-Fit Steel

The ability of large grain, REBa$_{2}$Cu$_{3}$O$_{7-\delta}$ [(RE)BCO; RE = rare earth] bulk superconductors to trap magnetic field is determined by their critical current. With high trapped fields, however, bulk samples are subject to a relatively large Lorentz force, and their performance is limited primarily by their tensile strength. Consequently, sample reinforcement is the key to performance improvement in these technologically important materials. In this work, we report a trapped field of 17.6 T, the largest reported to date, in a stack of two, silver-doped GdBCO superconducting bulk samples, each of diameter 25 mm, fabricated by top-seeded melt growth (TSMG) and reinforced with shrink-fit stainless steel. This sample preparation technique has the advantage of being relatively straightforward and inexpensive to implement and offers the prospect of easy access to portable, high magnetic fields without any requirement for a sustaining current source.Comment: Updated submission to reflect licence change to CC-BY. This is the "author accepted manuscript" and is identical in content to the published versio

Impact of composite scaffold degradation rate on neural stem cell persistence in the glioblastoma surgical resection cavity

Tumoricidal neural stem cells (NSCs) are an emerging therapy to combat glioblastoma (GBM). This therapy employs genetically engineered NSCs that secrete tumoricidal agents to seek out and kill tumor foci remaining after GBM surgical resection. Biomaterial scaffolds have previously been utilized to deliver NSCs to the resection cavity. Here, we investigated the impact of scaffold degradation rate on NSC persistence in the brain resection cavity. Composite acetalated dextran (Ace-DEX) gelatin electrospun scaffolds were fabricated with two distinct degradation profiles created by changing the ratio of cyclic to acyclic acetal coverage of Ace-DEX. In vitro, fast degrading scaffolds were fully degraded by one week, whereas slow degrading scaffolds had a half-life of >56 days. The scaffolds also retained distinct degradation profiles in vivo. Two different NSC lines readily adhered to and remained viable on Ace-DEX gelatin scaffolds, in vitro. Therapeutic NSCs secreting tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) had the same TRAIL output as tissue culture treated polystyrene (TCPS) when seeded on both scaffolds. Furthermore, secreted TRAIL was found to be highly potent against the human derived GBM cell line, GBM8, in vitro. Firefly luciferase expressing NSCs were seeded on scaffolds, implanted in a surgical resection cavity and their persistence in the brain was monitored by bioluminescent imaging (BLI). NSC loaded scaffolds were compared to a direct injection (DI) of NSCs in suspension, which is the current clinical approach to NSC therapy for GBM. Fast and slow degrading scaffolds enhanced NSC implantation efficiency 2.87 and 3.08-fold over DI, respectively. Interestingly, scaffold degradation profile did not significantly impact NSC persistence. However, persistence and long-term survival of NSCs was significantly greater for both scaffolds compared to DI, with scaffold implanted NSCs still detected by BLI at day 120 in most mice. Overall, these results highlight the benefit of utilizing a scaffold for application of tumoricidal NSC therapy for GBM

Passive heat stress reduces circulating endothelial and platelet microparticles

NEW FINDINGS: What is the central question of this study? Does passive heat stress of +2°C oesophageal temperature change concentrations of circulating arterial endothelial- and platelet-derived microparticles in healthy adults? What is the main finding and its importance? Concentrations of circulating endothelial- and platelet-derived microparticles were markedly decreased in heat stress. Reductions in circulating microparticles might indicate favourable vascular changes associated with non-pathological hyperthermia. Interest in circulating endothelial- and platelet-derived microparticles (EMPs and PMPs, respectively) has increased because of their potential pathogenic role in vascular disease and as biomarkers for vascular health. Hyperthermia is commonly associated with a pro-inflammatory stress but might also provide vascular protection when the temperature elevation is non-pathological. Circulating microparticles might contribute to the cellular adjustments and resultant vascular impacts of hyperthermia. Here, we determined whether circulating concentrations of arterial EMPs and PMPs are altered by passive heat stress (+2°C oesophageal temperature). Ten healthy young men (age 23 ± 3 years) completed the study. Hyperthermia was achieved by circulating ∼49°C water through a water-perfused suit that covered the entire body except the hands, feet and head. Arterial (radial) blood samples were obtained immediately before heating (normothermia) and in hyperthermia. The mean ± SD oesophageal temperature in normothermia was 37.2 ± 0.1°C and in hyperthermia 39.1 ± 0.1°C. Concentrations of circulating EMPs and PMPs were markedly decreased in hyperthermia. Activation-derived EMPs were reduced by ∼30% (mean ± SD; from 61 ± 8 to 43 ± 7 microparticles μl-1 ; P < 0.05) and apoptosis-derived EMPs by ∼45% (from 46 ± 7 to 23 ± 3 microparticles μl-1 ; P < 0.05). Likewise, circulating PMPs were reduced by ∼75% in response to hyperthermia (from 256 ± 43 to 62 ± 14 microparticles μl-1 ). These beneficial reductions in circulating EMPs and PMPs in response to a 2°C increase in core temperature might partly underlie the reported vascular improvements following therapeutic bouts of physiological hyperthermia.This study was funded through a Canadian Research Chair and an NSERC Discovery grant held by P.N.A. and a National Institutes of Health award (HL107715 to C.A.D.). A.R.B. is funded through an NSERC postdoctoral fellowship. D.F. is funded through the Swiss National Science Foundation. J.D. is funded by the Woolf Fisher Trust (New Zealand)

Modelling higher trapped fields by pulsed field magnetisation of composite bulk MgB 2 superconducting rings

Funder: EPSRCAbstract: The recent results of Hirano et al (2020 Supercond. Sci. Technol. 33 085002) reported a high trapped field of 1.61 T in a composite MgB2 ring comprising copper plates and and a soft iron yoke magnetised by pulsed field magnetisation (PFM). Inspired by these results, an investigation using systematic modelling methods was conducted to investigate the key parameters leading to the success of Hirano et al. Our results indicate that composite structures of MgB2 rings present a viable method of trapping high magnetic fields when magnetised with PFM. Leveraging a finite element method modelling framework with a commercial software package (COMSOL Multiphysics), we have successfully modelled the experimental data with excellent agreement. We have paid careful attention to the assumptions regarding the thermal physics, which enabled the successful and accurate modelling of the experiment. Exploiting the flexibility of computational modelling, we extend our studies to investigate the influence of the constituent elements of the composite bulk on the electromagnetic and thermal behaviour, and discuss in detail how each can enhance the trapped field performance of the bulk. Aided by the models, it is shown how the number of copper layers influences the elongation of the applied pulse, reducing the field penetration and the maximum temperature rise of the bulk. The addition of the iron yoke significantly increases the trapped field, by concentrating flux during and after the pulse