Comparison between the total TE group (n = 31), individuals with PFFD and without PFFD regarding physical activity level at work and in spare time according to WHO questionnaire n(%).

<p>Comparison between the total TE group (n = 31), individuals with PFFD and without PFFD regarding physical activity level at work and in spare time according to WHO questionnaire n(%).</p

Middle-aged individuals with thalidomide embryopathy have undergone few surgical limb procedures and demonstrate a high degree of physical independence - Fig 1

<p>Time needed for ADL for Group A (TE individuals with a disability-adjusted home and/or workplace and/or a personal assistant), (n = 12) and Group B (no need for disability adjustment and/or personal assistant) (n = 19). Significantly more individuals in Group A stated that they needed longer for ADL in the morning than those in Group B (p = 0.009).</p

Physical function measured by modified GFS and ADL for the total study group individuals with PFFD and without PFFD.

<p>Comparison calculated between individuals with PFFD and without PFFD. mean (SD)/range, n(%).</p

The need for different types of aid, disability adjustments and assistance to manage locomotion and daily activities in the total of 31 individuals with TE.

<p>The need for different types of aid, disability adjustments and assistance to manage locomotion and daily activities in the total of 31 individuals with TE.</p

Surgeries performed on the five persons with proximal focal femoral deficiency (PFFD).

<p>Surgeries performed on the five persons with proximal focal femoral deficiency (PFFD).</p

Age and gender demographics.

<p>Age and gender demographics.</p

MRI image of cervical spine in TE.

<p>MRI of the cervical spine for one of the TE patients where moderate disc degeneration was seen at C3-4, C4-5 and C5-6 level (A). Foraminal narrowing with nerve compromise can be seen here at level C5-6 on the right side (B and enlargement C, with arrow pointing at the disc/bulge/nerve compromise).</p

Individuals with disc degeneration, central or foraminal narrowing both sides.

<p>Individuals with disc degeneration, central or foraminal narrowing both sides.</p

Disc degeneration evaluated by Pfirrmann classification on MRI.

<p>Pfirrmann grading (I-V) of all cervical discs in 27 individuals with thalidomide embryopathy (TE), and 27 aged- and gender matched control subjects (CTR). Each cervical level (C2-C3-C6-C7) is presented separately and Fisher Exact Test was used for comparison between the two groups. Significant differences between the two groups were seen at all levels (p-values in the figure).</p

Comparison of degenerative findings in all cervical segments between the TE group and the CTR group, n (%).

<p>Comparison of degenerative findings in all cervical segments between the TE group and the CTR group, n (%).</p