Characteristics of the study population.

<p>Characteristics of the study population.</p

Birth variables as determinants of autonomic function adjusted for maternal and adult variables in men.

<p>All significant univariate associations are presented followed by adjustments for maternal and adult variables.</p

Characteristics of the NFBC1986 cohort.

<p>Data are given as MEAN (range) or as N (percentage).</p

Estimates of risk percentages for childhood obesity for given pairs of parental BMIs according to the NFBC1986 equation.

<p>Estimates are provided for three different combinations of birth weight, maternal professional category, number of household members and maternal gestational smoking, corresponding to three progressively higher risk backgrounds. Grey cells correspond to risk estimates within the highest risk quartile in the overall population.</p

Risk threshold and predictive properties corresponding to the 75° percentile of calculated risk for the obesity phenotypes in the NFBC1986.

<p>Risk threshold and predictive properties corresponding to the 75° percentile of calculated risk for the obesity phenotypes in the NFBC1986.</p

Stepwise multiple logistic models for prediction of obesity phenotypes: ORs and p values associated with predictors, AUROC and P of Hosmer-Lemeshow test in the final models (bold characters) and AUROCs and P of Hosmer-Lemeshow of each step (italic characters).

<p>Stepwise multiple logistic models for prediction of obesity phenotypes: ORs and p values associated with predictors, AUROC and P of Hosmer-Lemeshow test in the final models (bold characters) and AUROCs and P of Hosmer-Lemeshow of each step (italic characters).</p

Estimates of familial correlations ± standard error for serum haptoglobin concentration (656 familles/2680 individuals).

<p>* <i>P</i>≤0.05, ** <i>P</i>≤0.01, *** <i>P</i>≤0.001: compared to zero.</p><p>Model 1 estimated all eight correlations without adjustment.</p><p>Model 2 estimated all eight correlations with adjustment for age and BMI,</p><p>Model 3 estimated three correlations with adjustment for age and BMI with no gender effect on parent or offspring correlations: FS = MS = MD = FD and SS = SD = DD.</p><p>Model 4 estimated three correlations with adjustment for age, BMI and rs2000999 allelic frequency with no gender effect on parent or offspring correlations: FS = MS = MD = FD and SS = SD = DD.</p><p>Values in brackets were constrained to be equal to a preceding value according to the hypotheses of the model.</p><p>BMI: body mass index.</p

Phenotypic characteristics of the studied populations.

<p>CI: confidence interval; BMI: body mass index; LDL: low-density lipoprotein.</p

Variance components of serum haptoglobin concentrations (656 families/2680 individuals, rs2000999 & rs4788597 as allelic frequency).

*<p><i>P</i>≤0.05,</p>**<p><i>P</i>≤0.01,</p><p>*** <i>P</i>≤0.001.</p><p>BMI: body mass index.</p

Manhattan plot of the GWAS of the discovery cohort comprising 631 children.

<p><b>A</b>, A Manhattan plot showing the −log₁₀(<i>P</i> values) of SNPs from the association analysis of the 631 SFS children from stage 1. <b>B</b>, An overview of the −log₁₀(<i>P</i> values) of Chromosome 16. <b>C</b>, The genomic region of the 618 LD block displayed in UCSC Genome Browser.</p