Endogenous connections weighted by Bayesian model average in high suicide risk group (HSR), low suicide risk group (LSR) and healthy controls group (HC).

<p>Group mean estimates and SD (in brackets) are reported for endogenous connections which was weighted by Bayesian model average, the endogenous connections of all groups combined means that were significantly greater than zero across the three groups. We also report the group differences, which were identified using a series of ANOVAs. PCC = posterior cingulate cortex; MPFC = medial prefrontal cortex; “*” means significant statistical difference (statistical threshold <i>p</i><0.05).</p

Five hypothesized dynamic casual models during 2-back task.

<p>Each model includes the left medial prefrontal cortex (MPFC) and the ipsilateral posterior cingulate cortex (PCC), in which the arrows indicate extrinsic stimulation and functional connections direction. M1, M2 and M3 comprised bi-directional connections with respectively driving input into PCC or MPFC or both of the regions. M4 only contained unidirectional connection from the PCC to MPFC with driving input into PCC and M5 was completely opposite to M4. M1, M4 and M2 were identified as the optimal models in HSR, LSR and HC respectively. HSR: schizophrenic patients with high suicide risk; LSR: schizophrenic patients with low suicide risk; HC: healthy controls.</p

Regions with significant activations at rest state compared with 2-back task (<i>p</i><0.05, FWE corrected).

<p>Regions with significant activations at rest state compared with 2-back task (<i>p</i><0.05, FWE corrected).</p

Regions with significant activations at rest state among three groups compared with 2-back task.

<p>From A to D (upper part), brain areas are left medial prefrontal cortex (MPFC), left posterior cingulate cortex (PCC), left middle frontal gyrus and right precentral gyrus (<i>p</i><0.005, cluster >20). The signal changes in MPFC and PCC in the three groups are shown below (a and b). Error bars indicated 2 standard errors (SE), *<i>p<</i>0.05.</p

The demographic and clinical characteristics for high suicide risk group (HSR), low suicide risk group (LSR) and healthy controls group (HC).

<p>Data reflect mean (SD) unless otherwise stated. “–” reflect not applicable; “*” means significant statistical difference (statistical threshold <i>p</i><0.05). WAIS-I = Information subscale of the Wechsler Adult Intelligence Scale-Chinese Revised; WAIS-DS = Digit Symbol subscale of the Wechsler Adult Intelligence Scale-Chinese Revised; SAPS = Scale for the Assessment of Positive Symptoms; SANS = Scale for the Assessment of Negative Symptoms; SSRS = Schizophrenia Suicide Risk Scale; CPZ = Chlorpromazine. The proportion correct responses and response time(s) for correct responses were the performance during 2-back task.</p