Effects of hydrocellular foam dressing on CD44 mRNA levels in periwound epidermis.

<p>CD44 mRNA levels in periwound epidermis were measured by quantitative PCR and expressed as values relative to those of GAPDH. Bars are expressed as mean ± SE (n = 5). *<i>p</i> < 0.05 indicates values that are significantly different from the side of film dressing in rat skin.</p

Full-thickness cutaneous wound model.

<p>Two full-thickness wounds, a diameter of 1.5 cm, were created in the dorsolateral skin of five rats using sterile scissors. Each wound was covered with either a hydrocellular foam dressing (A) or the film dressing (B). A film dressing was used as a secondary dressing in both sides of individual rat and also used to keep the hydrocellular foam dressing attached to the wound.</p

Effects of hydrocellular foam dressing on wound healing in rat skin.

<p>Gross observations (A) and the relative wound areas (B) reveal increased wound contraction induced by hydrocellular foam dressing. Bars are expressed as mean ± SE (n = 4). *<i>p</i> < 0.05 indicates values that are significantly different from the side of film dressing in rat skin.</p

Effects of hydrocellular foam dressing on PPARα mRNA levels in periwound epidermis.

<p>The PPARα mRNA levels in periwound epidermis were measured by quantitative PCR and expressed as values relative to those of GAPDH. Bars are expressed as mean ± SE (n = 5). *<i>p</i> < 0.05 indicates values that are significantly different from the side of film dressing in rat skin.</p

Effects of hydrocellular foam dressing on level of hyaluronan and Has3 mRNA expression in periwound epidermis.

<p>Hyaluronan levels in periwound epidermis (A) were measured using a QnE hyaluronic acid ELISA assay. Has3 mRNA levels in periwound epidermis (B) were measured by quantitative PCR and expressed as values relative to those of GAPDH. Bars are expressed as mean ± SE (n = 4, 5). *<i>p</i> < 0.05 indicates values that are significantly different from the side of film dressing in rat skin.</p