1 research outputs found
New Application of Old Material: Chinese Traditional Ink for Photothermal Therapy of Metastatic Lymph Nodes
Finding
a simple and effective strategy to eliminate tumor metastatic
lymph nodes is highly desired in clinical tumor treatment. Herein,
we reported a Chinese traditional ink (Hu-ink)-based treatment for
photothermal therapy (PTT) of tumor metastatic lymph nodes. By simple
dilution, stable Chinese traditional ink dispersion was obtained,
which presents excellent photothermal effect because of its high absorption
in near-infrared (NIR) region. Meanwhile, as revealed by staining
and photoacoustic imaging, Hu-ink could transfer to nearby lymph nodes
after directly injected into the primary tumors. Under the guidance
of dual-modality mapping, the metastatic sentinel lymph nodes could
be subsequently eliminated by NIR irradiation. The good biocompatibility
of Hu-ink has also been verified by a series of experiments. Therefore,
the Hu-ink-based treatment exhibits great potential for PTT of tumor
metastatic lymph nodes in future clinical practice