Atrial fibrillation recurrence prevention after electrical cardioversion in high-risk patients – benefits of non-antiarrhythmic drugs

Publisher Copyright: © 2021 Kokina et al.Background: Recurrence prevention after Atrial Fibrillation (AF) termination by Eelectrical Cardioversion (ECV) remains challenging. Increasing attention is paid to pathophysiological effects of non-Antiarrhythmic Drugs (non-AADs), nevertheless, with heterogeneous results. Objective: We evaluated the potential benefits of different non-AADs as adjunctive therapy to Antiarrhythmic Drugs (AADs) for AF recurrence prevention after sinus rhythm restoration by ECV in high-risk patients. Methods: The study was conducted among high-risk AF patients after successful ECV. Prescription of class IC or class III AAD was required. Data were acquired in a face-to-face baseline interview and 1-, 3-, 6-, 9-, 12-month follow-up interviews. Results: 113 patients were included. Total AF recurrence rate reached 48.7%. Angiotensin-Converting Enzyme Inhibitor (ACEI) or angiotensin receptor blocker (ARB) intake, compared with non-use, demonstrated AF recurrence rate reduction by 8.5% (46.3 vs. 54.8%), with odds ratio (OR) reduced by 28.9% (OR 0.711, 95% confidence interval (CI) 0.310-1.631, p = 0.420). Among mineralocorticoid receptor antagonist (MRA) users, AF recurrence rate was reduced by 25.1% (29.6 vs. 54.7%) and OR by 65.1% (OR 0.349, 95%CI 0.138-0.884, p = 0.023). Present statin therapy reduced AF recurrence rate by 4.2% (46.8 vs. 51.0%) and OR by 15.5% (OR 0.845, 95%CI 0.402-1.774, p = 0.656). Diuretic use showed reduction of AF recurrence rate by 10.2% (41.7 vs. 51.9%) and OR by 33.9% (OR 0.661, 95%CI 0.297-1.469, p = 0.308). Conclusion: Non-AADs demonstrated practical benefits as adjunctive therapy to AADs for AF recurrence prevention after ECV in high-risk patients, with statistically significant results established for concomitant MRA intake.publishersversionPeer reviewe

Ultra-performance liquid chromatography – hybrid quadrupole – linear trap mass spectrometry method for determining ochratoxin A in coffee

Augsti efektīvās šķidruma hromatogrāfijas – daudzpakāpju kvadrupola masspektrometrijas metodes izstrāde ohratoksīna A noteikšanai kafijā. Kokina Aija, zinātniskie vadītāji: Dr. ķīm., asoc. prof. Vadims Bartkevičs, Mg. ķīm., doktorante Iveta Pugajeva. Maģistra darbs, 42 lappuses, 14 attēli, 11 tabulas, 28 literatūras avoti. Latviešu valodā. Literatūras apskatā apkopota informācija (laika periodā no 1971. līdz 2015. gadam) par ohratoksīnu A, tā veidošanās apstākļiem pārtikas produktos, par paraugu sagatavošanas metodēm un ohratoksīna A noteikšanas iespējām, izmantojot augsti efektīvo šķidruma hromatogrāfiju – masspektrometriju, kā arī OTA maksimāli pieļaujamās normas pārtikas produktos. Praktiskajā daļā tika izstrādāta AEŠH-MS/MS/MS metode ohratoksīna A noteikšanai kafijā un tā ir salīdzināta ar citām OTA noteikšanas metodēm. Izstrādātā AEŠH-MS/MS/MS metode tika pielietota OTA analīzei Latvijas tirgū pieejamajai kafijai. Izstrādātā metode tika validēta uz sekojošiem parametriem - selektivitāte, linearitāte, matricas efekts, atgūstamība un precizitāte, kā arī noteikta detektēšanas un kvantificēšanas robeža.Ultra-performance liquid chromatography – hybrid quadrupole – linear trap mass spectrometry method for determining ochratoxin A in coffee. Kokina Aija, scientific leaders: Dr. chem., asoc. prof. Vadims Bartkevičs, Mg. chem., doctoral student Iveta Pugajeva. Course work, 42 pages, 14 pictures, 11 tables, 28 literature sources. Latvian language. In literature review the information dated from 1997 to 2015 regarding ochratoxin A has been summarized. The literature review included the following topics: formation conditions in the food products, sample preparation methods and ochratoxin A detection capabilities using high-performance liquid chromatography - mass spectrometry, as well as maximum levels for this contaminant in foodstuffs. The practical part included the development of the UPLC-MS/MS/MS method for determination of ochratoxin A in coffee and comparison with other OTA determination methods. The elaborated method was used for analysis of Latvian market coffee samples. The main parameters of the method (selectivity, linearity, matrix effect, precision and repeatability) were validated and detection and quantification limits were assessed