Comparative Evaluation of In-Vitro Activity of Amoxicillin- Cloxacillin Combination against Clinical Isolates of Staphylococcus aureus.

Literature is replete with numerous reports of the high rate of emergence of resistant strains of staphylococcus aureus with decreased susceptibility to available penicillins. The strong need for the design and development of newer antibiotics and the re-engineering of existing ones with a view to limiting antibiotic resistance has been suggested by many researchers. The objective of this study was to explore and evaluate the susceptibility pattern of amoxicillin- cloxacillin combination (amoxiclox) against 69 clinical isolates of S. aureus. The methods adopted included disc diffusion, MIC and time-kill studies. Our results showed that only one of the 69 isolates demonstrated intermediate resistance to Amoxiclox. None of the isolates showed tolerance to either Amoxiclox or ciprofloxacin. However, all ciprofloxacin- resistant isolates were sensitive to Amoxiclox and highly resistant to Ampicillin-Cloxacillin combination. Killing curves on two isolates showed synergy in amoxicillin-cloxacillin combination. The valuable potentials of Amoxicillin- cloxacillin combination in the treatment of staphylococcal infections are indicated compared to other drugs used in this study. Keywords: Amoxicillin- Cloxacillin, In-Vitro Activity, Synergy, Staphylococcus aureus. NQJHM Vol. 14 (2) 2004: pp. 200-20

Comparative design analysis of permanent magnet rotor topologies for an aircraft starter-generator

This paper presents a comparative design study on Permanent Magnet (PM) rotor topologies for high speed aircraft starter-generators. The application requirements associated with the aircraft starter and generator operation is highlighted. Different rotor design concepts are investigated whilst keeping both the stator and the rotor diameter consistent. In addition, the core material, the electrical and magnetic constraints and the thermal and structural limitations are also kept consistent as the basis for comparison of different rotor topologies in this study. The performance of different optimal rotor designs is evaluated with Finite Element (FE) simulations and the results are presented in this paper. A Surface mounted PM (SPM) machine and a Spoke type PM machine designs are manufactured to demonstrate its ability to produce the required performance