22 research outputs found
Translocation between PI(4,5)P2-Poor and PI(4,5)P2-Rich Microdomains During Store Depletion Determines STIM1 Conformation and Gating of Orai1
La política como encuentro y respons-habilidad: Aprender a conversar con los otros enigmáticos
The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
The Ca(2+) and cAMP/PKA pathways are the primary signaling systems in secretory epithelia that control virtually all secretory gland functions. Interaction and crosstalk in Ca(2+) and cAMP signaling occur at multiple levels to control and tune the activity of each other. Physiologically, Ca(2+) and cAMP signaling operate at 5–10% of maximal strength, but synergize to generate the maximal response. Although synergistic action of the Ca(2+) and cAMP signaling is the common mode of signaling and has been known for many years, we know very little of the molecular mechanism and mediators of the synergism. In this review, we discuss crosstalk between the Ca(2+) and cAMP signaling and the function of IRBIT (IP(3) receptors binding protein release with IP(3)) as a third messenger that mediates the synergistic action of the Ca(2+) and cAMP signaling