KO systems based on Human needs Approach - to bring Harmony between homogeneity and heterogeneity of future information environment

Latest developments in the field of telecommunications combined with the Internet and the World Wide Web, have enabled us to transmit huge volumes of data, in wide range of forms and formats in an information environment which cuts across the geographic as well as political boundaries of the world. According to a study done by IDC, worldwide proliferation of PCs and smart phones, increased internet access and the boost in capturing data from machines such as surveillance cameras or smart meters has contributed to the exponential growth of digital data. By 2020, IDC projects that the digital universe will reach 40 ZB. However, currently majority of this data is untagged and unstructured (EMC Press release Dec 11, 2012). As of today only 3 percent of this potentially useful data is tagged, and even less is analyzed. Effective and Efficient KO tools play a major role in realizing the full potential of Big Data

SCREENING AND MOLECULAR DOCKING STUDIES OF CURCUMIN AND ITS DERIVATIVES AS INHIBITORS OF AMYLOID- β PROTEIN - A KEY PROTEIN IN ALZHEIMER'S DISEASE

 Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disease. This disease is characterized by progressive cognitive deteriorationalong with declining activities of the day to day and behavioral changes. One of the important pathogenesis in AD is the chronic inflammation ofneuron. Studies have demonstrated the associated inflammatory changes such as astrocytosis, microgliosis, and the presence of pro-inflammatorycomponents that accompany the deposition of amyloid-β (Aβ) peptide. In Alzheimer patients, a chronic inflammation occurs because of activatedmacrophages and an increased amount of cell signaling proteins. Curcuma longa of Zingiberaceae family is cultivated spice in India and other Asiancountries. Turmeric has a high content of curcuminoids and is recognized for its broad spectrum of biological activities. Molecular docking studieswere performed by selecting various curcuminoids as Aβ inhibitors.Methods: Docking studies help to understand the binding interactions of the protein with the ligands. Alzheimer's Aβ precursor(PDB ID: 1AAP) wasselected as the crucial protein involved in AD and curcuminoids were selected as ligands. Molecular properties and quantitative structure-activityrelationship (QSAR) model were calculated using Med Chem Designer and Build QSAR. Docking studies were performed using Autodock 4.0.Results: Docking results indicate that curcuminoids can be considered as inhibitors of AAP as they interact with the active site region.Conclusion: Docking analysis of auto dock binding energies and binding interactions of curcumin and its derivatives indicates that curcumin,curcumin bis acetate, bisdemethoxy curcumin, [18F] fluoropropyl substituted curcumin and tetrahydrocurcumin can be considered as probableinhibitors of AAP.Keywords: Alzheimer's disease, Curcuma longa, Curcuminoids, Docking, Quantitative structure-activity relationship, Amyloid protein