1 research outputs found
Determining Chiral Configuration of Diamines via Contact Angle Measurements on Enantioselective Alanine-Appended Benzene-Tricarboxamide Gelators
Spectroscopic
techniques exist that may discern between enantiomers
and assess chiral purity. A nonspectroscopic approach that may be
directly observed could provide numerous benefits. Using chiral alanine-appended
benzene-tricarboxamide gelators, we reveal a methanol gel system that
is capable of providing visual discrimination between enantiomers
of various diamines. Specifically, gelation is induced by supramolecular
nanofiber assembly resulting from interaction between a chiral gelator
and a diamine of opposing chirality (i.e., a heterochiral system).
Upon further implementing the chiral gelator in electrospun fibers
as solid state films, we revealed enantioselective surface wetting
properties that allowed for determining chirality through contact
angle measurements. While these two approaches of observable gelation
and surface wetting offer nonspectroscopic approaches, we also find
that the supramolecular nanofiber assembly was able to enhance the
induced circular dichroism signal resulting from addition of chiral
diamines, allowing precise quantification of their enantiomeric purity