The role of remixing for innovation in online innovation communities

Potentially innovative ideas are being generated, shared, and even remixed (recombined) in the online innovation communities. These ideas create new innovations through remixing of ideas. In this study, we investigate how remixing makes ideas more innovative in online innovation communities. Our model is validated through ordinary least squares regression on a secondary dataset of 57,049 ideas collected from one of the largest 3D printing online innovation communities, Thingiverse.com. The result shows that the number of prior ideas has an inverted U-shaped relationship with the idea\u27s degree of innovation and the cross-boundary remix has a positive effect on the idea’s degree of innovation

Design and Fabrication of Micro Optical Film by Ultraviolet Roll Imprinting

With increasing demand for large-scale functional optical films with microstructure in the field of flat panel displays, a technology capable of fabricating large-scale polymeric micro-patterns has received much attention. To fabricate large-area micro-optical films, we designed and constructed an ultraviolet roll imprinting system consisting of a roll stamp, a material dispensing unit, a pair of flattening rollers, a contact roller, and a releasing roller. Two methods for fabricating roll stamps were considered: direct machining of the roll base and wrapping a flat stamp around the roll base. As practical examples of the roll imprinting process, we designed and fabricated a lenticular lens array, a pyramidal pattern, and a microlens array, and measured and analyzed their geometrical and optical properties. Our results suggest that the proposed UV roll imprinting process is a feasible method for mass producing large-scale functional optical films

Ionic contrast across a lipid membrane for Debye length extension: towards an ultimate bioelectronic transducer

The design of bioelectronic devices that enables accurate detection of biomolecules in ionic solutions at physiologically-relevant concentrations remains a challenge. Here, the authors report a ion-impermeable supported lipid bilayer-assisted field-effect transistor platform for biomolecule detection

SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function

Glycine transporters (GlyT1 and GlyT2) that regulate levels of brain glycine, an inhibitory neurotransmitter with co-agonist activity for NMDA receptors (NMDARs), have been considered to be important targets for the treatment of brain disorders with suppressed NMDAR function such as schizophrenia. However, it remains unclear whether other amino acid transporters expressed in the brain can also regulate brain glycine levels and NMDAR function. Here, we report that SLC6A20A, an amino acid transporter known to transport proline based on in vitro data but is understudied in the brain, regulates proline and glycine levels and NMDAR function in the mouse brain. SLC6A20A transcript and protein levels were abnormally increased in mice carrying a mutant PTEN protein lacking the C terminus through enhanced beta-catenin binding to the Slc6a20a gene. These mice displayed reduced extracellular levels of brain proline and glycine and decreased NMDAR currents. Elevating glycine levels back to normal ranges by antisense oligonucleotide-induced SLC6A20 knockdown, or the competitive GlyT1 antagonist sarcosine, normalized NMDAR currents and repetitive climbing behavior observed in these mice. Conversely, mice lacking SLC6A20A displayed increased extracellular glycine levels and NMDAR currents. Lastly, both mouse and human SLC6A20 proteins mediated proline and glycine transports, and SLC6A20 proteins could be detected in human neurons. These results suggest that SLC6A20 regulates proline and glycine homeostasis in the brain and that SLC6A20 inhibition has therapeutic potential for brain disorders involving NMDAR hypofunction.11Nsciescopu