Chondrolipoma in the Pelvic Cavity: a Case Report

A chondrolipoma is an extremely rare form of a benign mesenchymal tumor containing mature cartilage and fatty tissue. Chondrolipomas may be found in almost any part of the body, particularly in the connective tissue of the breast, head and neck area, as well as in the skeletal muscle. However, to the best of our knowledge, chondrolipomas located in the pelvic cavity have not been reported. In this case report, we describe a case of a chondrolipoma in the pelvis, and show that it has its own characteristic imaging findings, which included the composition of fatty tissue and calcification in most parts, as well as some focal areas of chondroid tissue based on the CT and MR findings

Liposarcoma: exploration of clinical prognostic factors for risk based stratification of therapy

<p>Abstract</p> <p>Background</p> <p>Prognosis and optimal treatment strategies of liposarcoma have not been fully defined. The purpose of this study is to define the distinctive clinical features of liposarcomas by assessing prognostic factors.</p> <p>Methods</p> <p>Between January 1995 and May 2008, 94 liposarcoma patients who underwent surgical resection with curative intent were reviewed.</p> <p>Results</p> <p>Fifty patients (53.2%) presented with well differentiated, 22 (23.4%) myxoid, 15 (16.0%) dedifferentiated, 5 (5.3%) round cell, and 2 (2.1%) pleomorphic histology. With the median 14 cm sized of tumor burden, about half of the cases were located in the retroperitoneum (46.8%). Seventy two (76.6%) patients remained alive with 78.1%, and 67.5% of the 5- and 10-year overall survival (OS) rates, respectively. Low grade liposarcoma (well differentiated and myxoid) had a significantly prolonged OS and disease free survival (DFS) with adjuvant radiotherapy when compared with those without adjuvant radiotherapy (5-year OS, 100% vs 66.3%, P = 0.03; 1-year DFS, 92.9% <it>vs </it>50.0%, respectively, P = 0.04). Independent prognostic factors for OS were histologic variant (P = 0.001; HR, 5.1; 95% CI, 2.0 – 12.9), and margin status (P = 0.005; HR, 4.1; 95% CI, 1.6–10.5). We identified three different risk groups: group 1 (n = 66), no adverse factors; group 2, one or two adverse factors (n = 28). The 5-year OS rate for group 1, and 2 were 91.9%, 45.5%, respectively.</p> <p>Conclusion</p> <p>The histologic subtype, and margin status were independently associated with OS, and adjuvant radiotherapy seems to confer survival benefit in low grade tumors. Our prognostic model for primary liposarcoma demonstrated distinct three groups of patients with good prognostic discrimination.</p

A Multiinstitutional Consensus Study on the Pathologic Diagnosis of Endometrial Hyperplasia and Carcinoma

BACKGROUND: The purpose of this study was to examine the reproducibility of both the diagnosis of endometrial hyperplasia (EH) or adenocarcinoma, and the histologic grading (HG) of endometrioid adenocarcinoma (EC). METHODS: Ninety-three cases of EH or adenocarcinomas were reviewed independently by 21 pathologists of the Gynecologic Pathology Study Group. A consensus diagnosis was defined as agreement among more than two thirds of the 21 pathologists. RESULTS: There was no agreement on the diagnosis in 13 cases (14.0%). According to the consensus review, six of the 11 EH cases (54.5%) were diagnosed as EH, 48 of the 57 EC cases (84.2%) were EC, and 5 of the 6 serous carcinomas (SC) (83.3%) were SC. There was no consensus for the 6 atypical EH (AEH) cases. On the HG of EC, there was no agreement in 2 cases (3.5%). According to the consensus review, 30 of the 33 G1 cases (90.9%) were G1, 11 of the 18 G2 cases (61.1%) were G2, and 4 of the 4 G3 cases (100.0%) were G3. CONCLUSIONS: The consensus study showed high agreement for both EC and SC, but there was no consensus for AEH. The reproducibility for the HG of G2 was poor. We suggest that simplification of the classification of EH and a two-tiered grading system for EC will be necessary.This study was partly supported by research fund of Chungnam National University in 2007

난소 투명암

One hundred and twenty one cases of ovarian malignancy were reviewed over a period of 13 years from 1968 to 1980. Of these, 5 cases (4. 1%) were classified as clear cell carcinoma. In 1981 one additional case of clear cell carcinoma was uncovered. The mean age of the 6 patients was 58 years, with a range from 46 to 75 years. Presenting symptoms were abdominal pain or mass and/or distention. One case was associated with salpingeal endometriosis and ovarian endometriosis with transition to clear cell carcinoma. The striking features were clear cells (6 cases) and hobinail cells (4 cases), but papillary structure (4 cases) and parvilocular cystoma-like area 0 case) were also noted. Patients with solid tumor and in advanced stage seemed to have a worse prognosis than those with partly cystic and partly solid tumor and in less advanced stage. Histogenesis of clear cell carcinoma was studied and discussed in detail: origin from the ovarian surface epithelium seems to be the most frequent tissue of origin but rarely the tumor originate from epithelium of endometriostic cyst

윤상세관형성을 수반한 난소의 미분류 성색간질세포종(Sex-cord tumor with annular tubules)에 관한 비교형태학적 연구

In 1970, Scully (1970) reported 13 cases of a distinctive neoplasm that was characterized by the .formation of simple and complex an nular tubules and designated as a sex cord tumor with annular tubules (SCTAT)>>. Six of 13 cases were associated with Peutz-Jeghers syndrome (PJS). Scully maintained that the sex cord tumor with annular tubules arose from granulosa cells but grew in a pattern more characteristic of Sertoli cells. Hart et al. (1980) and Crissman and Hart (1981) considered SCTATs unassociated with the PJS to be granulosa cell tumors. Tavassoli and Norris(1980) suggested a Sertoli cell origin of the SCTAT unassociated with the PJS. Recently Young et al. (1982) maintained that the SCTAT is a distinctive ovarian neop- Presented in part at the Annual meeting of Korean Cancer Research Association, Seoul, Ko· rea, September, 1981, and at the 3rd Annnal meeting of Korean Society of Pathologists, Kyungjoo, Korea, October, 1981. This study was supported by the Seoul National University College of Medicine Research Fund (1981) Address for reprints: Geung Hwan Ahn, M.D Department of Pathology, College of Medicine, Seoul National University, 28 Yunkeun-Dong, Chongno-Ku, Seoul, Korea. t 1984년 6월 26힐 갱 수 lasm having morphologic features intermediate between those of the granulosa cell tumor and those of the Sertoli cell tumor with a capability of differentiating in both directions. The purpose of the present study is to define the nature of the SCTAT on the basis of light and electron microscopic study of 3 cases of the SCTAT. As a preliminary procedure to understand the processes involved in the differentiation of the gonads, a review of indifferent gonads and testes and ovaries at various stages of development was done because knowledge of their development is essential to define the nature and histogenesis of the SCTAT. A review of cryptorchid testes was also done

중신관기원(中腎管起源) 자궁부속기(子宮附屬器) 종양(腫瘍)

A peculiar right adnexal tumor was removed from a 53-year old multiparous woman. The tumor had distinctive diffuse, tubular and trabecular patterns. Ultrastructural study suggested derivation from wolffian duct

악성 임파종에 수반된 임파절 경색

Spontaneous infarction of lymph node seldom occurs because of dual vascular connection and low oxygen consumption of activated lymphocytes. Infarction of lymph node with malignant lymphoma is also rare, probably cue to the same reason as that of normal nodes , We report three ,ases of lymph node infarctiolj Lymphomain malignant lymphoma: two cases of lymphomatous lymph node and one case of nonlymphomatous lymph node. Their ages were 24,46 and 50 years Locations were two cervical and one inguinal areas. All cases were confirmed to be malignant lymphoma at the margin of infarcted node, other lymph nodes or previous biopsy. Histologic types of the cases were diffuse histiocytic (Rappaport) and large cell noncleaved type (Lukes·Collins). Infarcted area showed coagulation necrosis and surrounding granulation tissue. Special stains showed neither microorganism nor evidences of infection