Synthesis, characterization, and biological properties of composites of hydroxyapatite and hexagonal boron nitride

Hydroxyapatite (HA), obtained from bovine bones, was successfully reinforced with hexagonal boron nitrite (h-BN). h-BN/HA composites, with BN content up to 1.5 wt %, were sintered at various temperatures between 1000 and 1300 degrees C, in air. Well-sintered samples were obtained after sintering at 1200 and 1300 degrees C. The presence of h-BN contributed to dense, fine, and well-crystallized microstructure. The results of X-ray diffraction analysis and FT-IR spectroscopy showed that the produced composites comprised biphasic beta-TCP/HCA (HCA: carbonate partially substituted HA). High values of mechanical properties were achieved, namely compression strength 155 MPa for the sample 0.5% h-BN/HA and Vickers microhardness of 716 HV for the samples 1.5% h-BN/HA, both sintered at 1300 degrees C. U2OS human bone osteosarcoma proliferation and cell viability showed no adverse effect in the presence of h-BN/HA, suggesting the potential use of the produced materials as safe biomaterials in bone tissue engineering

The relationship of argyrophilic proteins of the nuclear-organized regions and atopic dermatitis in children

Background: The argyrophilic proteins of nuclear-organized regions (AgNOR), visualised with colloidal silver methods as black dots are known as AgNOR. To date, the relationship between AgNOR and cancer and inflammatory conditions has been investigated. However, there has been no report investigating the relationship between AgNOR and atopic dermatitis. The aim of this study was to investigate the relationship between atopic dermatitis and AgNOR in paediatric patients. Methods: Twenty-nine children with atopic dermatitis and 23 healthy children were included in the study. AgNOR test results were analysed prospectively. Results: The mean AgNOR number (40.19 ± 21.06) in the patient group was significantly higher than the control group (12.83 ± 10.40) (P <.001). Conclusions: This study investigated the association between AgNOR and atopic dermatitis for the first time in the literature. In the study, atopic dermatitis and AgNOR were found to be related. In the study, for the first time with the ROC analysis, AgNOR limit values with high sensitivity and specificity levels were determined in the diagnosis of atopic dermatitis

Synthesis, characterization, and biological properties of composites of hydroxyapatite and hexagonal boron nitride

Hydroxyapatite (HA), obtained from bovine bones,was successfully reinforced with hexagonal boron nitrite (h-BN). h-BN/HA composites, with BN content up to 1.5 wt %,were sintered at various temperatures between 1000 and13008C, in air. Well-sintered samples were obtained after sin-tering at 1200 and 13008C. The presence of h-BN contributedto dense, fine, and well-crystallized microstructure. Theresults of X-ray diffraction analysis and FT-IR spectroscopyshowed that the produced composites comprised biphasic b-TCP/HCA (HCA: carbonate partially substituted HA). High val-ues of mechanical properties were achieved, namelycompression strength 155 MPa for the sample 0.5% h-BN/HAand Vickers microhardness of 716 HV for the samples 1.5% h-BN/HA, both sintered at 13008C. U2OS human bone osteosar-coma proliferation and cell viability showed no adverse effectin the presence of h-BN/HA, suggesting the potential use ofthe produced materials as safe biomaterials in bone tissueengineering