1 research outputs found
β‑Cyclodextrin-Bearing Gold Glyconanoparticles for the Development of Site Specific Drug Delivery Systems
Three novel gold nanoparticles containing
multiple long, flexible
linkers decorated with lactose, β-cyclodextrin, and both simultaneously
have been prepared. The interaction of such nanoparticles with β-d-galactose-recognizing lectins peanut agglutinin (PNA) and
human galectin-3 (Gal-3) was demonstrated by UV–vis studies.
Gal-3 is well-known to be overexpressed in several human tumors and
can act as a biorecognizable target. This technique also allowed us
to estimate their loading capability toward the anticancer drug methotrexate
(MTX). Both results make these glyconanoparticles potential site-specific
delivery systems for anticancer drugs