Myositic Type of Idiopathic Orbital Pseudotumor in a 4-Year-Old Child: A Case Report

Idiopathic orbital pseudotumor is a benign, noninfectious, and nonneoplastic disease with unknown cause. It is the third most common orbital disease after thyroid orbitopathy and lymphoproliferative disorder. Idiopathic orbital pseudotumor is extremely rare in pediatric age group and may cause real diagnostic problems. This paper describes a 4-year-old girl who presented with sudden ptosis in the right eye and swollen eyelid. She recovered completely with high-dose steroid therapy. We report clinical and magnetic resonance imaging findings of orbital myositis, which is a rare subtype of idiopathic orbital pseudotumor in children and needs to be differentiated from other orbital disease especially malignancy

Do MEFV mutations influence arterial stiffness in FMF patients?

Background: Pulse wave velocity (PWV) is the most used technique to evaluate the arterial elasticity, which is an early indicator of atherosclerosis. We aimed to evaluate if MEFV Mutations influence arterial stiffness in patients with Familial Mediterranean fever (FMF) Methods: 70 patients diagnosed with FMF and 50 age-and sex-matched controls were included in the study. Genetic analysis of the patients was performed. After the measurement of PWV; the presence of AS was determined. Results: Mean PWV value and arterial stiffness frequency of FMF patients were significantly higher than the control group (p <0.001, p <0.001) respectively. In addition, FMF patients with M694Vmutations had higher PWV values and arterial stiffness frequency than those with other mutations. (p=0.045), (p=0.001). There were no differences within all genetic mutation types in terms of arterial stiffness frequency.Conclusions: As a result, due to subclinical inflammation in FMF patients, they have risk for cardiovascular complications. These patients especially those with M694Vmutations have to be followed more closely because of increased cardiovascular risk and PWV measurements may be a good tool to detect early development of atherosclerosis.

Investigation of Serum Folate-Receptor-1 in Patients with Non- Small Cell Lung Cancer

Objective: Histopathological overexpression of folate receptor-1(FOLR1) involved in folate transport in cell growth has been reported in various cancers. Increased serum FOLR1 (sFOLR1) has also been reported in epithelial ovarian cancer. The aim was to investigate sFOLR1 levels in non-small cell lung cancer(NSCLC) patients and the response prediction of the standard chemotherapy targeting folic acid metabolism. Methods: In this prospective study, sFOLR1 levels were investigated in 30 healthy individuals and 60 patients with stage4 malign metastatic NSCLC before and after standard chemotherapy. The commercial immunoassay(ELISA) kit was used for the analysis of sFOLR1. Serum carcinoembryonic antigen(CEA), vitamin B12, and folate levels were also investigated. Results: In NSCLC patients sFOLR1 levels were significantly higher(p<0.001) than the healthy individuals. After 3 months of standard treatment, sFOLR1 was significantly lower than pre-treatment values in NSCLC patients(p<0.001). Diagnostic accuracy was strong in the differentiation of NSCLC patients from healthy individuals(AUC= 0.966). with the cut-off point of 82.45 pg/ml, the sFOLR1 level was performed with 95% sensitivity and 99% specificity. Pretreatment sFOLR1 levels were significantly lower in patients with-response to standard chemotherapy(p<0.01). The best predictive value was determined as 393.80 pg/ml. At the end of the 401 days, a significant difference was found in patients with high sFOLR1 predictive value. The median overall survival(OS) duration was 288 days for all patients (95% GA 198.13-377.87). Median progression-free survival(PFS) was 321 days(95% GA 211.90-430.10). Conclusions: For monitoring standard chemotherapy with drugs targeting folic acid metabolism, sFOLR-1 levels be an biomarker

nvestigation of Serum Folate-Receptor-1 in Patients with Non- Small Cell Lung Cancer

Objective: Histopathological overexpression of folate receptor-1(FOLR1) involved in folate transport in cell growth has been reported in various cancers. Increased serum FOLR1 (sFOLR1) has also been reported in epithelial ovarian cancer. The aim was to investigate sFOLR1 levels in non-small cell lung cancer(NSCLC) patients and the response prediction of the standard chemotherapy targeting folic acid metabolism. Methods: In this prospective study, sFOLR1 levels were investigated in 30 healthy individuals and 60 patients with stage4 malign metastatic NSCLC before and after standard chemotherapy. The commercial immunoassay(ELISA) kit was used for the analysis of sFOLR1. Serum carcinoembryonic antigen(CEA), vitamin B12, and folate levels were also investigated. Results: In NSCLC patients sFOLR1 levels were significantly higher(p<0.001) than the healthy individuals. After 3 months of standard treatment, sFOLR1 was significantly lower than pre-treatment values in NSCLC patients(p<0.001). Diagnostic accuracy was strong in the differentiation of NSCLC patients from healthy individuals(AUC= 0.966). with the cut-off point of 82.45 pg/ml, the sFOLR1 level was performed with 95% sensitivity and 99% specificity. Pretreatment sFOLR1 levels were significantly lower in patients with-response to standard chemotherapy(p<0.01). The best predictive value was determined as 393.80 pg/ml. At the end of the 401 days, a significant difference was found in patients with high sFOLR1 predictive value. The median overall survival(OS) duration was 288 days for all patients (95% GA 198.13-377.87). Median progression-free survival(PFS) was 321 days(95% GA 211.90-430.10). Conclusions: For monitoring standard chemotherapy with drugs targeting folic acid metabolism, sFOLR-1 levels may be an important biomar

Investigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 levels in irritable bowel syndrome

Aim: Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients. Materials and methods: We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits. Results: Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between groups. Conclusion: These results show that alterations in MMIF and MCP-1 affect the proinflammatory process. They also suggest that MMIF and MCP-1 may play a substantial role in IBS

Iron Deficiency Anaemia is Associated with Decreased Levels of Macrophage Migration Inhibitory Factor and Monocyte Chemoattractant Protein-1

Many bodily systems are affected by iron deficiency anaemia (IDA), including the immune system. However, the pathophysiological mechanisms whereby this anaemia promotes deterioration in immunity remain largely unexplained. In order to enlighten this pathophysiological link, serum levels of macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1), which play an important roles in a healthy functioning immune system, were examined in patients with IDA and healthy volunteers. A total of 30 patients with IDA (mean age 33.6+/-7.8 years, 30% male) and 30 healthy individuals (mean age 30.1 +/- 8.8 years, 27 % male) were included. Serum MIF and MCP-1 levels were measured in a sandwich-assay format, using commercial enzyme-linked immunosorbent assay kits. There was no statistically significant difference in age and gender distribution between participants with IDA and controls (p> 0.05). Serum MIF and MCP-1 concentrations were lower in the IDA group than in the control group (p < 0.005, and p < 0.01, respectively). When considering the role of MIF and MCP-1 in maintaining the normal immune response of the organism, a decrease in production in patients with IDA may contribute to immune dysfunction in these individuals

(The prevalence of gestational diabetes mellitus in NamÕk Kemal University Training and Research Hospital)

Giriş: Her yıl önemli sayıda kadını etkileyen Gestasyonel diabetes mellitus (GDM) hem gebeler hem de bebekleri için istenmeyen sağlık problemlerine yol açmaktadır. Bu çalışma, Namık Kemal Üniversitesi Araştırma ve Uygulama Hastanesinde Gestasyonel Diyabetes Mellitus prevalansını değerlendirmeyi ve diğer çalışmaların sonuç- larıyla karşılaştırmayı amaçlamaktadır. Materyal ve Metot: Ocak 2010 ile Mayıs 2013 tarihleri arasında 24 28 Haftalık gebelik süresinde Namık Kemal Üniversitesi Araştırma ve Uygulama Hastanesinde kabul edilen gebeler çalışmaya dahil edildi. Yapılan dosya taramasında 502 gebeye 50 gram Glukoz Yükleme Testi (GYT) uygulandığı, test sonuçlarına göre bunların 29una da 100 gram Oral Glukoz Tolerans Testi (OGTT) yapıldığı tespit edildi. Bulgular: Gebelerin tamamına yapılan 50 g Glukoz Yükleme Testi 29 olguda pozitif olarak bulundu. Tarama testi yapılan gebelerin 13 tanesinde 100 g OGTT pozitif olarak değerlendirilmiş ve hastanemize başvuran gebelerin gestasyonel diyabet prevelansı Carpenter ve Caustan kriterlerine göre %2,59 bulunmuştur. Sonuçlar: Gestasyonel diabetes mellitus prevalansı Namık Kemal Üniversitesi Araştırma ve Uygulama Hastanesinde Türkiyenin diğer bölgelerinden rapor edilen epidemiyolojik çalışmalara göre daha düşük bulundu.Background: Gestational diabetes mellitus (GDM) affects a significant number of women each year and it is associated with a wide range of adverse outcomes for pregnants and their babies. The present study aimed to evaluate the prevalence of Gestational diabetes mellitus in Nam&Otilde;k Kemal University Training and Research Hospital and to compare the results of other studies. Material and Methods: From January 2010 to May 2013, patients admitted to gynecology clinic with 24 28 week pregnancy were studied. A glucose challenge test (GCT) was given to 502 pregnant women and based on the results 29 went on to take an oral glucose tolerance test (OGTT). Results: 502 pregnant women tested, Fifty gram Glucose Challenge Test was performed on all pregnant women which was positive only in 29 cases, and in 13 of them 100 gram oral glucose tolerance test was positive The prevalence of gestational diabetes in pregnant women who were admitted to our hospital was 2.59% according to Carpenter and Caustan diagnostic criteria Conclusions: The prevalence of Gestational diabetes mellitus was found to be lower in in Nam&Otilde;k Kemal University Training and Research Hospital rather than the other regions of Turkey as reported in epidemiological studies

Spontaneous Perforation of Cirrhotic Acid After Observed Interesting Development: Case Report

Sirotik asit tedavisinde kullanılan parasentez, yüksek volümle yapıldığında dolaşım disfonksiyonu ve buna sekonder böbrek fonksiyon bozukluklarına neden olabilir. Kliniğimizde, masif asit ve hepatorenal sendrom nedeniyle takip ettiğimiz hastamızda spontan perforasyon gelişmesi takibinde, kreatinin değerlerinde dramatik bir düşme ve normal değerlerine gerileme gözlendi. Sonuç olarak; parasentez ile kreatinin değerlerinde yükselme olmadan da fazla miktarda asit mayisi direne edilebileceği, hastaların hemodinamik durumu da göz önüne alınarak, tedavi planlanırken akılda bulundurulmalıdır.Paracentesis which is used for cirrhotic acid treatment may cause renal dysfunction secondary to circulatory dysfunction when performed with high volume. In our clinic, spontaneous ascites perforation has developed in a patient hospitalized due to massive ascites and hepatorenal syndrome. In the follow-up period, dramatical decline was observed in creatinine values. In conclusion; it should be kept in mind that, a large amount of ascites drainage may be performed without increase in creatinine values during paracentesis taking into account the hemodynamic status of the patient

Spontaneous Perforation of Cirrhotic Acid After Observed Interesting Development: Case Report

Paracentesis which is used for cirrhotic acid treatment may cause renal dysfunction secondary to circulatory dysfunction when performed with high volume. In our clinic, spontaneous ascites perforation has developed in a patient hospitalized due to massive ascites and hepatorenal syndrome. In the follow-up period, dramatical decline was observed in creatinine values. In conclusion; it should be kept in mind that, a large amount of ascites drainage may be performed without increase in creatinine values during paracentesis taking into account the hemodynamic status of the patient

A MSFD complementary approach for the assessment of pressures, knowledge and data gaps in Southern European Seas : the PERSEUS experience

PERSEUS project aims to identify the most relevant pressures exerted on the ecosystems of the Southern European Seas (SES), highlighting knowledge and data gaps that endanger the achievement of SES Good Environmental Status (GES) as mandated by the Marine Strategy Framework Directive (MSFD). A complementary approach has been adopted, by a meta-analysis of existing literature on pressure/impact/knowledge gaps summarized in tables related to the MSFD descriptors, discriminating open waters from coastal areas. A comparative assessment of the Initial Assessments (IAs) for five SES countries has been also independently performed. The comparison between meta-analysis results and IAs shows similarities for coastal areas only. Major knowledge gaps have been detected for the biodiversity, marine food web, marine litter and underwater noise descriptors. The meta-analysis also allowed the identification of additional research themes targeting research topics that are requested to the achievement of GES. 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license.peer-reviewe