Protective and ameliorative effects of Curcumin and/or Quercetin against gentamicin induced testicular damage in rats

The aminoglycoside Gentamicin is a commonly used antibiotic counteracting the Gram-ve microorganisms. Rats administered with Gentamicin showing a reduced testicular weight and inhibited spermatogenesis, as gentamicin generates ROS, decreasing the antioxidant reserve and accelerate mitochondrial dysfunction which then leads to apoptosis and testicular tissue destruction. This study was designed to investigate the protective effects of curcumin and/or quercetin on the gentamicin induced testicular damage or toxicity in sexually mature adult rats. Pre-treatment with curcumin and/or quercetin, markedly inhibited and ameliorated the reduction in sperm count, viability, motility and sperm production in gentamicin treated rats. Moreover, curcumin and/or quercetin, significantly reduce teratospermia including head or tail abnormalities that observed in the gentamicin treated rats. These abnormalities were effectively normalized by curcumin and/or quercetin pretreatment improving the testicular tissue via counteracting of ROS, improvement of spermatogenesis and ameliorate the sperms quality and quantity. In conclusion supplementation of curcumin and/or quercetin improving the sperm count and morphology via testicular cell repair, counteracting the undesirable effect of gentamicin

Middle-East OBGYN graduate education (MOGGE) foundation practice guidelines: use of labor charts in management of labor. Practice guideline no. 04-O-21

Since the 50 s of the last century, labor charts have been proposed and appraised as a tool to diagnose labor abnormalities and guide decision-making. The partogram, the most widely adopted form of labor charts, has been endorsed by the world health organization (WHO) since 1994. Nevertheless, recent studies and systematic reviews did not support clinical significance of application of the WHO partogram. These results have led to further studies that investigate modifications to the structure of the partogram, or more recently, to reconstruct new labor charts to improve their clinical efficacy. This guideline appraises current evidence on use of labor charts in management of labor specially in low-resource settings

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.The aim of this study was to inform vaccination prioritization by modelling the impact of vaccination on elective inpatient surgery. The study found that patients aged at least 70 years needing elective surgery should be prioritized alongside other high-risk groups during early vaccination programmes. Once vaccines are rolled out to younger populations, prioritizing surgical patients is advantageous