S3 Appendix -

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Flow Chart showing recruitment and follow-up during treatment period.

<p>Flow Chart showing recruitment and follow-up during treatment period.</p

mITT and Per protocol analysis at end of treatment.

<p>mITT and Per protocol analysis at end of treatment.</p

Comparison of safety of FDC and loose formulation of anti TB treatment during the intensive and continuation phases of TB treatment.

<p>Comparison of safety of FDC and loose formulation of anti TB treatment during the intensive and continuation phases of TB treatment.</p

Evidence of Non Inferiority.

<p>The dotted lines indicate the margin on non-inferior for the difference between the FDC and the LF region. Error bars represent the 90% confidence interval in the risk difference. In Sensitivity 1 is a complete case analysis where all missing EOT culture results in the mITT cohort are excluded. PP indicates per protocol.</p

Comparison of <i>N. meningitidis</i> carriage by swabbing method.

<p>The prevalence and 95% confidence intervals of <i>N. meningitidis</i> carriage as determined by swabbing the posterior pharynx behind the uvula (U) or swabbing the posterior pharynx behind the uvula plus one tonsil (T) by center and overall. </p