3 research outputs found

    Hypokalaemic periodic paralysis in patients presenting with severe limb paralysis at PUMHSW Nawabshah

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    Objective: To determine the hypokalemic periodic paralysis rate in patients presenting with severe limb paralysis at PUMHSW Nawabshah. Methodology: This descriptive was conducted Medical department of Peoples Medical College & hospital Nawabshah from October 2017 to April 2018. All the patients having age 20-50 years of either gender with severe limb paralysis at Intensive care unit & medical ward of Peoples Medical College Hospital Nawabshah were included. Demographics information was obtained. After clinical examination along with detailed medical history regarding hypokalemic periodic paralysis (HPP) and severe limb paralysis, patients were subjected to relevant investigations especially potassium and x-rays. Data was collected via self-made proforma. Results: Total of 150 patients were studied; their mean age was 33.4±5.69 years.  22(14.7%) study subjects were female and 128(85.3%) were male patients. Hypokalemic periodic paralysis was seen in 77(51.3%) patients, presenting with severe limb paralysis. There was significant impact of age and gender on frequency of Hypokalemic periodic paralysis. Conclusion: Hypokalemic periodic paralysis (HPP) is a significant factor of acute flaccid paralysis, as well as prompt management and early recognition of this condition would give pleasing result and in some cases, it would prevent additional attacks

    Temperate hyper-saline ecosystems induce spatial distribution and halo-thermotolerance potential in indigenous cultivable bacterial community

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    Extreme environmental conditions like high salinity and temperature are continuously affecting fertile lands and trigger an ecological imbalance, thereby inducing indigenous microbial communities for adaptation to such extreme environments. Present study relates with the isolation and characterization of halo-thermotolerant bacteria (HTTB) from hyper-saline areas of districts Kashmore and Khairpur, Sindh, Pakistan. The isolated bacteria were initially screened for their tolerance to elevated salt concentrations and extreme temperature ranges. Out of twenty-six bacterial isolates, six bacteria from district Kashmore (60%) and thirteen bacterial isolates from district Khairpur (81.25%) tolerated NaCl concentration up to 15–17% (w/v), and grown efficiently when incubated in the temperature ranges 55–65 °C. The principle component and multivari- ate cluster analyses revealed three different clusters of HTTB bacteria based on their tolerance and spatial distribution. In general, the hyper-saline environments of district Kashmore harbored more HTTB than Khairpur, but individually there was extreme halotolerance and thermotolerance among Khairpur isolates. Finally, the PCR-based molecular typing of 16S rRNA genes revealed, majority of the isolates were identified to be various strains of genus Bacillus, i.e., Bacillus subtilis, B. licheniformis, B. aerius, B. vallismortis, B. aquimaris and B. flexus. Only one bacterial strain, i.e., KJ1WB, was identified as Pseudomonas pseudoalcaligenes. These HTTB bacterial strains may extend significant potential for future applications like environmental, biotechnological and enormous industrial due to their valuable enzymatic profiles and metabolite repositories
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