1 research outputs found
Anticancer potential of furanocoumarins: Mechanistic and therapeutic aspects
Cancer is one of the most extreme medical conditions in both developing
and developed countries around the world, causing millions of deaths
each year. Chemotherapy and/or radiotherapy are key for treatment
approaches, but both have numerous adverse health effects. Furthermore,
the resistance of cancerous cells to anticancer medication leads to
treatment failure. The rising burden of cancer overall requires novel
efficacious treatment modalities. Natural medications offer feasible
alternative options against malignancy in contrast to western
medication. Furanocoumarins' defensive and restorative impacts have been
observed in leukemia, glioma, breast, lung, renal, liver, colon,
cervical, ovarian, and prostate malignancies. Experimental findings have
shown that furanocoumarins activate multiple signaling pathways, leading
to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle
arrest in malignant cells. Additionally, furanocoumarins have been shown
to have chemo preventive and chemotherapeutic synergistic potential when
used in combination with other anticancer drugs. Here, we address
different pathways which are activated by furanocoumarins and their
therapeutic efficacy in various tumors. Ideally, this review will
trigger interest in furanocoumarins and their potential efficacy and
safety as a cancer lessening agents