11 research outputs found
A Short Review on Copper Calcium Titanate (CCTO) Electroceramic: Synthesis, Dielectric Properties, Film Deposition, and Sensing Application
The Role of Oxidative Stress in Koenimbine-Induced DNA Damage and Heat Shock Protein Modulation in HepG2 Cells
Hawthorn (Crataegus Oxyacantha) Extract in the Drinking Water of Broilers on Growth and Incidence of Pulmonary Hypertension Syndrome (PHS)
ABSTRACT Hawthorn extract has been used for ameliorating cardiac disorders and pulmonary hypertension. Flavonoids and oligomeric proanthocyanidins are considered to be responsible for the positive health effects of hawthorn extract. The effect of Hawthorn extract in the water supply on feed intake, growth, carcass traits, internal organ weight, cardiac indices, the concentration of serum proteins and the incidence of pulmonary hypertension syndrome was evaluated in broiler chickens. At one day-of-age, 225 chickens were assigned to one of three experimental groups where 0, 0.1 and 0.2 ML of hawthorn extract was added per one liter of drinking water. Feed intake, live weight gain and carcass weight increased when hawthorn extract was included in the drinking water at a level of 0.1 and 0.2 ML/L (p<0.05). Compared to no extract, the addition of Hawthorn extract in the drinking water (p<0.05) reduced the proportion of the body attributed to abdominal fat, liver and heart (p<0.05), and decreased the percentage of birds that died or showed clinical symptoms of pulmonary hypertension syndrome (p<0.05). Serum protein concentration was (p<0.05) higher in chickens that received the hawthorn extract in the drinking water compared to no addition of extract in the drinking water. Hawthorn extract has shown potential for use as a herbal medicine to aid in the prevention of physiological cardiac disorders and pulmonary hypertension in chickens
Prevalence of the CYP2D6*10 (C100T), *4 (G1846A), and *14 (G1758A) alleles among Iranians of different ethnicities
Ali Bagheri,1 Behnam Kamalidehghan,2 Maryam Haghshenas,3 Parisa Azadfar,4 Leila Akbari,4 Mohammad Hossein Sangtarash,1 Faramarz Vejdandoust,5 Fatemeh Ahmadipour,2 Goh Yong Meng,6 Massoud Houshmand7,8 1Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran; 2Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 3Department of Biology, Pardis International Unit, University of Guilan, Rasht, Iran; 4Department of Biology, Science and Research Branch, Azad University, Tehran, Iran; 5Department of Biology, Azad University, Ashkezar Branch, Yazd, Iran; 6Department of Animal Science, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia; 7Medical Genetics Department, Special Medical Center, 8Medical Genetics Department, National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran Abstract: The presence of polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. Here, we compared the prevalence of the CYP2D6*10, *4, and 14* alleles in an Iranian population of different ethnicities with those of other populations. Allele and genotype frequency distributions of CYP2D6*10 variants and predicted phenotypes including extensive metabolizers, intermediate metabolizers, and poor metabolizers were analysed in blood samples of 300 unrelated healthy individuals in an Iranian population using polymerase chain reaction (PCR)-restriction fragment length polymorphism, PCR-single-strand conformation polymorphism, and direct genomic DNA sequencing. The CYP2D6*4 (G1846A) and *14 (G1758A) allelic frequencies were not detected in different ethnicities, demonstrating the absence of a significant contribution of these alleles in Iranian populations. However, the T/T, C/T, and C/C genotype frequencies of the CYP2D6*10 allele were significantly different (P<0.01) in all Iranian ethnic groups. Additionally, the frequency of the homozygous T/T variant of the CYP2D6*10 allele was significantly high in the Lure (P<0.017) and low in the Kurd (P<0.002) ethnicities. The frequency of the T/T variant of the CYP2D6*10 allele in central Iran was the highest (P<0.001), while the south of Iran had the lowest frequency (P<0.001). The frequency of the C/T variant of the CYP2D6*10 allele was significantly a bit high (P<0.001) in females compare to males, while the frequencies of the T/T variant in females is similar to males, which are 24.4% and 24.3%, respectively. In contrast to absence of the CYP2D6*4 (G1846A) and *14 (G1758A) alleles in Iranian populations of different ethnicities, the prediction of the CYP2D6*10 allele is required in drug research and routine treatment, where the information would be helpful for clinicians to optimize therapy or identify persons at risk of adverse drug reactions before clinical trials. Approximately 39.3% of subjects (24.3% homozygous T/T CYP2D6*10 as poor metabolizers and 15% heterozygous C/T CYP2D6*10 as intermediate metabolizers) had this allele; therefore, the harmful effects of drugs are relatively common among Iranians. Keywords: pharmacogenetics, polymorphism, cytochrome P450 genes, CYP, Iranian population, antipsychotics, antidepressants 
Hawthorn (Crataegus Oxyacantha) Extract in the Drinking Water of Broilers on Growth and Incidence of Pulmonary Hypertension Syndrome (PHS)
<div><p>ABSTRACT Hawthorn extract has been used for ameliorating cardiac disorders and pulmonary hypertension. Flavonoids and oligomeric proanthocyanidins are considered to be responsible for the positive health effects of hawthorn extract. The effect of Hawthorn extract in the water supply on feed intake, growth, carcass traits, internal organ weight, cardiac indices, the concentration of serum proteins and the incidence of pulmonary hypertension syndrome was evaluated in broiler chickens. At one day-of-age, 225 chickens were assigned to one of three experimental groups where 0, 0.1 and 0.2 ML of hawthorn extract was added per one liter of drinking water. Feed intake, live weight gain and carcass weight increased when hawthorn extract was included in the drinking water at a level of 0.1 and 0.2 ML/L (p<0.05). Compared to no extract, the addition of Hawthorn extract in the drinking water (p<0.05) reduced the proportion of the body attributed to abdominal fat, liver and heart (p<0.05), and decreased the percentage of birds that died or showed clinical symptoms of pulmonary hypertension syndrome (p<0.05). Serum protein concentration was (p<0.05) higher in chickens that received the hawthorn extract in the drinking water compared to no addition of extract in the drinking water. Hawthorn extract has shown potential for use as a herbal medicine to aid in the prevention of physiological cardiac disorders and pulmonary hypertension in chickens.</p></div