A REVIEW ON PHYTOPHARMACOLOGICAL ACTIVITY OF ALPINIA GALANGA

Alpinia galanga plant which is associated with family Zingiberaceae is mainly scattered in tropical areas and widely known for ethno medicine. Against fungi and bacteria rhizome extract have a maximum inhibitory effect. Alpinia galanga plant is used in medicine and in food preparation. Rhizome extract of Alpinia galanga have high phenolic and flavonoid contents when compared to leaf extract. Because of elevated phenolic and flavonoid content in rhizome extract of Alpinia galanga there is noticeable antimicrobial as well as radical scavenging potential. It is a well-known official drug thought out the country as integrated contribution of nature. It is commonly used for the management of eczema, coryza, bronchitis, otitis interna, gastritis, ulcers, morbilli and cholera, pityriasis versicolor, to clear the mouth, emaciation. The different parts of the plant have various effects like antifungal, antiprotozoal, antiplatelet, antiviral, antidiabetic, immunomodulatory, antibacterial, anti-oxidant effects, hypolipidemic and many others. The essential oil of A. galanga identified 1, 8-cineol as a bioactive agent having antifeeding activity. An aqueous acetone extract of fruit of Alpinia galanga shows inhibitory effect on melanogenesis (formation of melanin). By using different methods, active constituent namely, 1'-acetochavicol acetate in hexane extract of Alpinia galanga rhizome was investigated for their corrosion inhibition properties. The current review add significant information about its, pharmacological activities, medicinal properties and phytochemical investigations as a traditional drug to cure for a number of diseases. Every fraction of the plant has valuable properties that can deliver humanity. The complete plant will be broadly investigated for further future prospective

COMPARATIVE EFFECT OF BETA BLOCKERS AND ANGIOTENSIVE RECEPTOR BLOCKERS ON BLOOD GLUCOSE LEVEL IN HYPERTENSIVE PATIENTS IN UNIVERSITY HOSPITAL

Objective: There is highly co-incidence between hypertension and insulin resistance which is the important causative factor to develop diabetes mellitus (DM). There is paucity of data to establish the effect of beta-blockers and ARB on blood glucose level in Indian population. Therefore the present study was planned to search so that confederation among Indian population in a teaching hospital. Methods: The research study was carried out in 85 hypertensive patients without diabetes visiting the OPD of University teaching hospital (Majeedia hospital) New Delhi. Blood glucose levels and drug history of hypertensive patients were observed during four month of study. Results: The gender distribution of hypertensive patients reveals a higher percentage of incidences in males (53%) as compared to females (47%). Hypertensive patient without diabetes mellitus (DM) on beta blockers shows higher incidence of impaired glucose tolerance (IGT) (13.3%) and DM (5%) as compared to patient receiving ARBs as antihypertensive therapy. There was proportionate increase in incidence as the duration of therapy. None of the patients who were on angiotensin receptor blockers (ARBs) reported any incidence of IGT or DM. Conclusion: Beta blockers  may be the risk factor to develop diabetes mellitus type 2 on long term use as an antihypertensive therapy. There were no any incidence of impaired glucose tolerance or diabetes mellitus found in case of patients taking ARBs as an antihypertensive therapy so it can be safely prescribe in hypertensive patients associated with diabetes mellitus type 2. Key Words: Hypertension, Diabetes mellitus, Impaired glucose tolerance, Beta blockers and ARBs

Neuroinflammation: A Potential Risk for Dementia

Dementia is a neurodegenerative condition that is considered a major factor contributing to cognitive decline that reduces independent function. Pathophysiological pathways are not well defined for neurodegenerative diseases such as dementia; however, published evidence has shown the role of numerous inflammatory processes in the brain contributing toward their pathology. Microglia of the central nervous system (CNS) are the principal components of the brain’s immune defence system and can detect harmful or external pathogens. When stimulated, the cells trigger neuroinflammatory responses by releasing proinflammatory chemokines, cytokines, reactive oxygen species, and nitrogen species in order to preserve the cell’s microenvironment. These proinflammatory markers include cytokines such as IL-1, IL-6, and TNFα chemokines such as CCR3 and CCL2 and CCR5. Microglial cells may produce a prolonged inflammatory response that, in some circumstances, is indicated in the promotion of neurodegenerative diseases. The present review is focused on the involvement of microglial cell activation throughout neurodegenerative conditions and the link between neuroinflammatory processes and dementia

Interaction between the place of residence and wealth on the risk of overweight and obesity in Bangladeshi women

Background The prevalence of overweight and obesity in women has increased significantly over the last few decades in Bangladesh, a rapidly urbanising developing country. However, little is known regarding the association between the interaction of the place of residence and household wealth with overweight and obesity, particularly in women from developing countries. Objective The objective of this study is to find the association between the interaction of the place of residence and wealth with overweight and obesity among Bangladeshi women. Methods This study utilised data from the four Bangladesh Demographic Health Surveys conducted in 2004, 2007, 2011 and 2014 with a total of 54337 women aged 15–49 years. Multivariate logistic regression was used for the analyses. Results The prevalence of overweight and obesity among women aged 15–49 years in Bangladesh has considerably increased from 9.96% in 2004 to 24.43% in 2014. The interaction between wealth and place of residence has been found to be associated with obesity. Urban wealthy and richest women were 4.23 (OR: 4.23, 95% CI: 1.25–14.34) and 5.99 (OR: 5.99, 95% CI: 1.91–18.74) times more likely to be obese compared to their rural counterparts in the period 2004. Urban richest were 2.94 times (OR: 2.94, 95% CI: 1.20–7.24) more likely to be obese against their rural counterparts for the survey year 2014. Conclusions The place of residence is not associated with obesity, but its interaction with wealth is significant

Financing an efficient adaptation programme to climate change: A contingent valuation method tested in Malaysia

This paper assesses farmers’ willingness to pay for an efficient adaptation programme to climate change for Malaysian agriculture. We used the contingent valuation method to determine the monetary assessment of farmers’ preferences for an adaptation programme. We distributed a structured questionnaire to farmers in Selangor, Malaysia. Based on the survey, 74% of respondents are willing to pay for the adaptation programme with several factors such as socio-economic and motivational factors exerting greater influences over their willingness to pay. However, a significant number of respondents are not willing to pay for the adaptation programme. The Malaysian government, along with social institutions, banks, NGOs, and media could come up with fruitful awareness programmes to motivate financing the programme. Financial institutions such as banks, insurances, leasing firms, etc. along with government and farmers could also donate a substantial portion for the adaptation programme as part of their corporate social responsibility (CSR)

Optimal Placement of Reclosers in a Radial Distribution System for Reliability Improvement

There is a need for the optimal positioning of protective devices to maximize customers satisfaction per their demands. Such arrangement advances the distribution system reliability to maximum achievable. Thus, radial distribution system (RDS) reliability can be improved by placing reclosers at suitable feeder sections. This article presents comprehensive details of an attempt to determine the reclosers’ optimal location in an RDS to maximize the utility profit by reliability improvement. Assessment of different reliability indices such as SAIDI, SAIFI, CAIFI, CAIDI, etc., with recloser placement, exhibits a considerable improvement in these indices in contrast with the absence of recloser. Consequently, a new bidirectional formulation has been proposed for the optimized arrangement of reclosers’. This formulation efficiently handles the bidirectional power flow, resulting from distributed generation (DG) unit (s) in the system. The proposed model has been solved for a test system by utilizing the Genetic algorithm (GA) optimization method. Later, test results conclude that reclosers’ optimal placement contributes significantly towards utility profit with minimum investment and outage costs

Optimal Placement of Reclosers in a Radial Distribution System for Reliability Improvement

There is a need for the optimal positioning of protective devices to maximize customers satisfaction per their demands. Such arrangement advances the distribution system reliability to maximum achievable. Thus, radial distribution system (RDS) reliability can be improved by placing reclosers at suitable feeder sections. This article presents comprehensive details of an attempt to determine the reclosers’ optimal location in an RDS to maximize the utility profit by reliability improvement. Assessment of different reliability indices such as SAIDI, SAIFI, CAIFI, CAIDI, etc., with recloser placement, exhibits a considerable improvement in these indices in contrast with the absence of recloser. Consequently, a new bidirectional formulation has been proposed for the optimized arrangement of reclosers’. This formulation efficiently handles the bidirectional power flow, resulting from distributed generation (DG) unit (s) in the system. The proposed model has been solved for a test system by utilizing the Genetic algorithm (GA) optimization method. Later, test results conclude that reclosers’ optimal placement contributes significantly towards utility profit with minimum investment and outage costs

The Effect of Socio-Demographic Factors in Health-Seeking Behaviors among Bangladeshi Residents during the First Wave of COVID-19

Background: Socio-demographic variability among nations and cultures highly influences health-seeking behavior (HSB) in managing endemic or pandemic diseases. The present study aimed to investigate the influence of socio-demographic factors on HSB among Bangladeshi residents during the first wave of COVID-19. Methods: A cross-sectional online survey was performed with Bangladeshi residents (60% male and 40% female; age range: 10–60 years or above) from May to July 2020. Information was collected from the participants who resided in slum areas or did not have internet access through face-to-face surveys, maintaining spatial distancing and proper preventive measures. A self-reported and structured questionnaire, including socio-demographic and HSB, was undertaken, and the data was analyzed using a convenience sampling method. Finally, among the 947 participants, 20 were selected using a stratified random sampling technique for in-depth-interview (IDI). The linear regression analysis was performed to determine the influence of socio-demographic factors on HSB. Results: Only about 4.2% of respondents did not wear masks, but nearly half of the participants (46.6%) did not use hand gloves. The mean score of HSB was 9.98 (SD = 2.01) out of 16, with a correct overall rate of 62.4%. As per regression analysis, higher HSBs were found among participants who reported older age (>50 years) (9.96 ± 2.45), educated unemployed students (10.1 ± 1.95), higher education (10.5 ± 1.76), and higher-income (10.4 ± 1.59); in contrast, participants living in slum areas (8.18 ± 2.34) and whose source of income was business (8.46 ± 2.04) exhibited lower HSBs. Females, compared to men, showed better HSB in every aspect, apart from online food ordering. Qualitative data showed that the younger generation is more aware because of their access to information and persuaded the older generations to follow health-seeking protocols. The results also showed that some lower-income slum-dwellers have access to information and healthcare through their employers. IDIs also found cultural, religious, and mental-health affect people’s adherence to health-seeking guidelines and regulations. Conclusions: The findings suggest that socio-demographic factors significantly influenced HSBs during COVID-19 in the Bangladeshi population. Authorities can use these observations to systematically manage future endemics or pandemics