A unique case of successful twin pregnancy reaching term in a patient with uterus bicornis unicollis

Abnormal fusion of the Mullerian ducts or failure of absorption of the septum causes varying degrees of congenital uterine malformation. Twin gestation in a case of bicornuate uterus is rare. We are reporting this case because of its rare presentation, where a case of undiagnosed twins managed to reach full-term after spontaneous conception. We report here a 30 year old gravida four para one with no live issues who presented at term in labour. Per Abdomen examination suggested a twin gestation which was confirmed by ultrasonography. Both the twins were delivered by an emergency caesarean section. Intraoperatively the uterus was found to be bicornuate uterus (bicornis unicollis) with both the babies in two different horns

Sheridan School of Architectural Technology Volume 2 [S2017]

Welcome to Sheridan’s School of Architectural Technician/Technology printed portfolio volume 2. A combination of student work as well as faculty research has once again been been amalgamated into a print and digital portfolio showing the academic excellence of our program. Student work in the book is largely from the course CADD 39788 Architectural Computer Visualisation with a few projects from other courses making guest appearances. Our faculty research section near the back of the book offers insights into the professional interests and engagements of Sheridan professors.https://source.sheridancollege.ca/fast_books/1002/thumbnail.jp

Molecular virulence determinants of Magnaporthe oryzae: disease pathogenesis and recent interventions for disease management in rice plant

Magnaporthe oryzae, causative agent of the rice blast disease, is a major concern for the loss in yield of rice crop across the globe. It is known for its characteristic melanised dome-shaped appressorium containing a dense melanin layer. The melanised layer is of considerable importance as it is required to generate turgor pressure for initiating peg formation, consequently rupturing the plant cuticle. Various virulence factors play an important role in the disease progression as well as pathogenesis of the fungus. Some of the proteins encoded by virulence genes are associated with signalling, secondary metabolism, protein deprivation, defence responses and conidiation. The purpose of this review is to describe various fungal virulence determinants and provide insights into the molecular mechanisms that are involved in progression of the disease. Besides, the recent molecular approaches being employed to combat the rice blast have also been elaborated

Potential treatments of COVID-19: Drug repurposing and therapeutic interventions.

The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is caused when Spike-protein (S-protein) present on the surface of SARS-CoV-2 interacts with human cell surface receptor, Angiotensin-converting enzyme 2 (ACE2). This binding facilitates SARS-CoV-2 genome entry into the human cells, which in turn causes infection. Since the beginning of the pandemic, many different therapies have been developed to combat COVID-19, including treatment and prevention. This review is focused on the currently adapted and certain other potential therapies for COVID-19 treatment, which include drug repurposing, vaccines and drug-free therapies. The efficacy of various treatment options is constantly being tested through clinical trials and in vivo studies before they are made medically available to the public

Potential treatments of COVID-19: Drug repurposing and therapeutic interventions

The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is caused when Spike-protein (S-protein) present on the surface of SARS-CoV-2 interacts with human cell surface receptor, Angiotensin-converting enzyme 2 (ACE2). This binding facilitates SARS-CoV-2 genome entry into the human cells, which in turn causes infection. Since the beginning of the pandemic, many different therapies have been developed to combat COVID-19, including treatment and prevention. This review is focused on the currently adapted and certain other potential therapies for COVID-19 treatment, which include drug repurposing, vaccines and drug-free therapies. The efficacy of various treatment options is constantly being tested through clinical trials and in vivo studies before they are made medically available to the public

Antifungal Resistance Analysis of Environmental Isolates of Aspergillus in North India

Triazoles are the major group of antifungals for treating Aspergillus infections. The morbidity and mortality associated with these infections is high and rate of treatment failure is more in patients infected with azole resistant Aspergillus. The azole resistant Aspergillus isolates have been recovered from both azole treated and azole naive patients. Thus, there may be an environmental route of exposure to azole resistant Aspergillus. The present study was envisaged for the isolation and enumeration of environmental isolates of Aspergillus resistant to medically available antifungal azole drugs in North Indian environment. A total of 25 soil samples were collected from North Indian agricultural farms where azole pesticides were being used. The soil samples were screened for Aspergillus isolates by serial dilution pour plate method. Further, their drug susceptibility testing was performed using disc diffusion, E- strip and micro-broth dilution method against medically available triazoles: itraconazole, ketoconazole, fluconazole and voriconazole. A total of 41 Aspergillus species were isolated from the soil samples. Based on conventional microscopic assay, 13 of them were identified as Aspergillus fumigatus, 9 as Aspergillus niger, 5 as Aspergillus terreus, 3 as Aspergillus nidulans, 1 as Aspergillus flavus and 9 as other Aspergillus species. Resistance for all tested antifungal drugs was detected in 7.3% Aspergillus isolates and 43.7% isolates were resistant to any of the tested azole drugs. The results demonstrated that Aspergillus isolates resistant to medical triazoles are present in the agricultural farms

Simple Predictors of Mortality in Acute Pancreatitis

Background: Various historical studies have found that hypoxia portends a poor prognosis in patients hospitalized with acute pancreatitis. The objective of this study is to test early respiratory compromise on hospital presentation as a mortality predictor in acute pancreatitis. Secondary aims of the study were assessing prognostication abilities of the quick sequential organ failure assessment (qSOFA) and hypoalbuminemia in acute pancreatitis. Methods: This is a retrospective observational study based on adult patients hospitalized for acute pancreatitis. The data were collected from eight standalone emergency departments and five hospitals within Henry Ford Health System of Southeast Michigan. Patients with lipase levels less than three times the upper limit of the normal laboratory range were excluded. The primary outcome was inpatient mortality. Univariate and multivariate logistic regression was performed to determine predictors of adverse outcomes. The main variable of interest was respiratory compromise, defined as an initial SpO2 of 92% on presentation. We combined other key variables on presentation to derive an area under the curve (AUC) for predicting mortality. Results: The study included 2,090 patients, mean age 55.5 years (SD 17.5) and 51.5% female. The median presenting lipase was 976 U/L (IQR 281-2500). Death was uncommon (n=34, 1.6%). Via univariate analysis, highly significant predictors of mortality were SpO2 92%, qSOFA score 2, and low albumin. Patients with a presenting SpO2 92% had 9.2% mortality, in contrast to a 1.3% mortality rate among those with an SpO2 above 92% on presentation (OR 7.5, 95% CI 3.1-17.7). Those with a qSOFA score 2 suffered 9.8% mortality, compared to an average 1.3% mortality rate among those with a qSOFA of 0 or 1 (OR 8.6, 95% CI 3.9-18.9). Adjusting for age, gender, race, leukocytosis, hematocrit, and major comorbidities, qSOFA 2 remained a significant predictor of mortality (OR 2.6, 95% CI 1.7-4.1, p \u3c 0.001). Low albumin (OR 2.7, 95% CI 1.2-6.2, p 0.02) and SpO2 92% (OR 2.6, 95% CI 1.0-7.1, p 0.05) also remained significant predictors. By combining qSOFA with the presence of low albumin and SpO2 92% into a novel early acute pancreatitis score (EAPS), the EAPS score had good accuracy for predicting mortality (AUC 0.80, 95% CI 0.72-0.89). Conclusions: Independent predictors of mortality on initial presentation include low albumin, SpO2 92%, and a qSOFA score 2. Perhaps these simple prognosticators can guide clinical practice by more precisely identifying those with acute pancreatitis who are more critically ill and could benefit from closer monitoring