As we like it: did the UK's 2016 EU referendum reveal the "will of the people?"

Rhetoric surrounding the United Kingdom’s 2016 referendum on continued European Union (EU) membership frequently has invoked the “will of the people.” Addressing the House of Commons in March 2019, then–Prime Minster Theresa May stated that “my sense of responsibility and duty has meant that I have kept working to ensure that we deliver on the result and the will of the people” (March 27, 2019).1 May’s successor, Boris Johnson, appealed to the same notion when suggesting in the Daily Telegraph (September 15, 2019) that opposition parties were “united in wanting to cancel the referendum result…and overturn the will of the people.” On the other side of the debate, Caroline Lucas (currently the sole Member of Parliament for the UK’s Green Party) stated that “[e]very recent opinion poll shows that the will of the people has changed since [the referendum]” (December 4, 2018)

Exploring Protein–Nanoparticle Interactions with Coarse‐Grained Protein Folding Models

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136668/1/smll201603748.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136668/2/smll201603748-sup-0001-S1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136668/3/smll201603748_am.pd

The effects of divorce in a society with ever-changing family structures

Divorce rates have doubled since the 1970s, this has influenced both the structure and the impact of the family. It is imperative not to overlook the large and growing population of children affected by divorce. This paper will discuss the differences of important variables involved, such as age, gender and cultural background. In addition, it will discuss in detail outreach ideas and intervention strategies including small groups, mentoring programs, and bibliotherapy that have all been effective in supporting these children and their families in this crucial change of family structure. Children in single parent and blended families are considered at-risk because research shows these children are at a high risk for veering off the path of becoming productive adults who contribute positively to society (Anderson, 2002). School counselors and faculty are at times the only advocates for children when parents are distracted with working on their own issues that are brought on by the divorce. A school can provide a neutral environment, allowing continued involvement by both parents in their child\u27s life, which promotes academic success. School counselors can act as advocates because of their continued involvement, their knowledge of developmental needs, and their training in interventions that can reduce at-risk behavior

Under pressure – The working situation of Swedish healthcare managers during the first wave of COVID-19

Introduction: The aim of this study is to provide insight into the psychosocial work situation of hospital managers during the first wave of the COVID-19 pandemic. Methods: Mixed-effect modelling was used on survey data on job demands, job resources, job motivation, and work-life balance among over 500 managers working in 55 departments of a large Swedish university hospital in 2019 and 2020. Responses from 6011 employees were then used to stratify the analysis for COVID-19 exposure. Inductive content analysis was applied to open-ended questions on the managers’ views on organisational prerequisites during the onset of the pandemic. Results: The proportion of managers reporting difficulties with role clarity, quantitative demands, decision-making authority, and emotional support, time for recovery at work, motivation deficits, or problems with work-life balance clearly increased during the first wave of the pandemic. The proportion of managers reporting negative responses was higher in departments with high COVID-19 exposure. The qualitative analysis shows that overall governance in terms of clear, fair, and well-communicated routines, resource allocation, and division of responsibilities constituted an important framework for managerial during the crisis. First-line managers also require a mandate to re-organize their roles and their teams to successfully adapt to the situation. Organisational and social support was also important resources. Discussion: This is the first study investigating healthcare managers’ work situation during the first wave of the COVID-19 pandemic in a Swedish context. As expected, it indicates an increasingly strained work situation during the crisis, but it also provides findings on organisational prerequisites that allow healthcare managers to cope with stressful situations. In line with previous research on organisational resilience, the study provides suggestions for how higher-level managers can act in order to provide front-line managers with the organisational prerequisites they need to adapt, learn and develop successfully during times of unpredictability, insecurity, and rapid change in order to offer the best possible support to health care workers

Limitations of variable number of tandem repeat typing identified through whole genome sequencing of Mycobacterium avium subsp. paratuberculosis on a national and herd level

Background: Mycobacterium avium subsp. paratuberculosis (MAP), the causative bacterium of Johne’s disease in dairy cattle, is widespread in the Canadian dairy industry and has significant economic and animal welfare implications. An understanding of the population dynamics of MAP can be used to identify introduction events, improve control efforts and target transmission pathways, although this requires an adequate understanding of MAP diversity and distribution between herds and across the country. Whole genome sequencing (WGS) offers a detailed assessment of the SNP-level diversity and genetic relationship of isolates, whereas several molecular typing techniques used to investigate the molecular epidemiology of MAP, such as variable number of tandem repeat (VNTR) typing, target relatively unstable repetitive elements in the genome that may be too unpredictable to draw accurate conclusions. The objective of this study was to evaluate the diversity of bovine MAP isolates in Canadian dairy herds using WGS and then determine if VNTR typing can distinguish truly related and unrelated isolates.<p></p> Results: Phylogenetic analysis based on 3,039 SNPs identified through WGS of 124 MAP isolates identified eight genetically distinct subtypes in dairy herds from seven Canadian provinces, with the dominant type including over 80% of MAP isolates. VNTR typing of 527 MAP isolates identified 12 types, including “bison type” isolates, from seven different herds. At a national level, MAP isolates differed from each other by 1–2 to 239–240 SNPs, regardless of whether they belonged to the same or different VNTR types. A herd-level analysis of MAP isolates demonstrated that VNTR typing may both over-estimate and under-estimate the relatedness of MAP isolates found within a single herd.<p></p> Conclusions: The presence of multiple MAP subtypes in Canada suggests multiple introductions into the country including what has now become one dominant type, an important finding for Johne’s disease control. VNTR typing often failed to identify closely and distantly related isolates, limiting the applicability of using this typing scheme to study the molecular epidemiology of MAP at a national and herd-level.<p></p&gt

Gulls as Sources of Environmental Contamination by Colistin-resistant Bacteria

In 2015, the mcr-1 gene was discovered in Escherichia coli in domestic swine in China that conferred resistance to colistin, an antibiotic of last resort used in treating multi-drug resistant bacterial infections in humans. Since then, mcr-1 was found in other human and animal populations, including wild gulls. Because gulls could disseminate the mcr-1 gene, we conducted an experiment to assess whether gulls are readily colonized with mcr-1 positive E. coli, their shedding patterns, transmission among conspecifics, and environmental deposition. Shedding of mcr-1 E. coli by small gull flocks followed a lognormal curve and gulls shed one strain \u3e101 log10 CFU/g in their feces for 16.4 days, which persisted in the environment for 29.3 days. Because gulls are mobile and can shed antimicrobial-resistant bacteria for extended periods, gulls may facilitate transmission of mcr-1 positive E. coli to humans and livestock through fecal contamination of water, public areas and agricultural operations

DMD: A Large-Scale Multi-Modal Driver Monitoring Dataset for Attention and Alertness Analysis

Vision is the richest and most cost-effective technology for Driver Monitoring Systems (DMS), especially after the recent success of Deep Learning (DL) methods. The lack of sufficiently large and comprehensive datasets is currently a bottleneck for the progress of DMS development, crucial for the transition of automated driving from SAE Level-2 to SAE Level-3. In this paper, we introduce the Driver Monitoring Dataset (DMD), an extensive dataset which includes real and simulated driving scenarios: distraction, gaze allocation, drowsiness, hands-wheel interaction and context data, in 41 hours of RGB, depth and IR videos from 3 cameras capturing face, body and hands of 37 drivers. A comparison with existing similar datasets is included, which shows the DMD is more extensive, diverse, and multi-purpose. The usage of the DMD is illustrated by extracting a subset of it, the dBehaviourMD dataset, containing 13 distraction activities, prepared to be used in DL training processes. Furthermore, we propose a robust and real-time driver behaviour recognition system targeting a real-world application that can run on cost-efficient CPU-only platforms, based on the dBehaviourMD. Its performance is evaluated with different types of fusion strategies, which all reach enhanced accuracy still providing real-time response.Comment: Accepted to ECCV 2020 workshop - Assistive Computer Vision and Robotic

Angel investor's selection criteria: a comparative institutional perspective

Despite the important role of angel investors as critical financial providers for new ventures, little is known regarding how institutions make their investment decisions. While angels make decisions based on selection criteria during the first stage, they are also embedded within and affected by different institutional settings and as a result weight these criteria differently than other investors. We compare angel investors' selection criteria in China and Denmark using the comparative institutional perspective. We use a policy capturing approach and hierarchy linear modeling, revealing that since Chinese angels are embedded within relationship-based institutional settings they tend to reply more on strong ties such as family and friends in management team, as well as weighting risks less compared to Danish angels operating within more rule-based institutional contexts