Green Synthesis of Nalidixic Acid by Ionic Liquid: Using ionic liquid for drug synthesis

In this study, a green process was applied for the preparation of nalidixic acid by the assistance of an ionic liquid. Nalidixic acid was prepared by reaction of 6-methylpyridin-2-amine, ethyl formate and diethyl malonate in tris-(2-hydroxyethyl) ammonium acetate solution as ionic liquid (IL) which was provided by reaction of triethanolamine and acetic acid. The 1HNMR, 13CNMR, FTIR, mass spectroscopy and melting point were used to characterize the structure of the synthesized compounds. The ionic liquid was recovered and reused for four runs. This method introduces a novel idea for synthesis of nalidixic acid with high yield (86%) and the least damage to the environment. This IL can be used as a green solvent in synthesis of compounds instead of using harmful solvents