The effect of hydro-alcoholic extract of celery on male rats in fertility control and sex ratio of rat offspring

BACKGROUND AND OBJECTIVE: Celery (Apium graveolens), in traditional medicine is known as appetite and libido stimulant, and also there has been referred to its effect on miscarriage and catamenia. This plant with known plant compounds could be an option for fertility control. This study was conducted to evaluate the effect of hydro-alcoholic extract of celery on male rats in fertility control and sex ratio of rat offspring. METHODS: In this experimental study, 20 male rats were divided randomly into 4 groups, 5 in each group. Control group received no treatment; Sham group received 1 ml normal saline and the treatment groups 1 and 2 received hydro-alcoholic extract of celery in doses of 100 and 200 mg/Kg/BW respectively for 5 weeks. After mating each male rat with two female rats, the number of delivered mice and the number of offspring and their sex were recorded and compared 30 days after the birth. FINDINGS: There was no significance difference between the experimental and control group (p>0.05). The result showed a significant decrease in the number of offspring in doses of 100 and 200 mg/kg (4.25±0.25 and 4.50±0.32 respectively) compared to the control group (7.11±0.26), also a significant increase in the sex ratio in dose of 100 mg/kg (2.93±0.30) compared to the control group (0.98±0.11) was observed (p<0.05). CONCLUSION: It seems that consumption of celery in male decreases the number of offspring and increases the male genesis; because it does not affect on childbirth. It may be useful safely in pregnancy controlling. © 2014, Babol University of Medical Sciences. All rights reserved

The effect of Halcoholic extract of celery leaves on the delivery rate (fertilization and stillbirths), the number, weight and sex ratio of rat off spring

Objectives: Infertility is one of the most common health problems in the world. Different plants are used in traditional medicine to treat infertility. Celery is rich in flavonoids and vitamins E and C. The present study investigated the effect of hydroalcoholic extract of celery leaves on the delivery rate, number, weight and sex ratio of rat offspring. Materials and Methods: In this experimental study, 45 Wistar rats were randomly divided into three groups of fifteen (five male and 10 female rats per group). The control group received 1 ml of distilled water, and experimental groups received respectively doses of 100 and 200 mg/kg/BW celery extract for five weeks by gavage. During the fifth week each male rat was mated with two female rats from the same group in a separate cage. After a week, every female rat was kept in the separate cages. Females received celery extract during pregnancy and until childbirth. Finally, the number of the delivery females, number, weight and sex ratio of offspring were recorded. The data were analyzed by one-way ANOVA test using SPSS15 software. Results: The number of the delivery rats in the experimental groups was not significantly different than the control group (P>0.05). The number of newborns was significantly increased in each experimental group compared to the control group (P0.05). Conclusions: Celery improved fertility due to have flavonoid and antioxidant activity, and its consumption in both sexes can be useful in the treatment of infertility. © 2014 AENSI Publisher All rights reserved

The effects of hydro-alcoholic extract of celery on lipid profile of rats fed a high fat diet

Background and Objectives: Decrease in serum lipids by dietary or pharmacological intervention prevents progression of atherosclerosis and cardiovascular diseases. The aim of this study was to investigate the effects of hydro-alcoholic extract of celery (Apium graveolens) on lipid profile of rats fed a high fat diet. Materials and Methods: In this experimental study, 24 Wistar rats were randomly allocated into four groups. The control group received saline with high-fat diet and treatment groups did hydroalcoholic extract at doses of 100 and 200 mg/kg/BW with high fat diet by gavage over a 30-day period. Afterwards, the serum levels of lipids (triglyceride, cholesterol, LDL, HDL, and VLDL) were determined. The data were analyzed by one-way ANOVA test using SPSS15 software. Results: Hydro-alcoholic extract of celery significantly decreased cholesterol and LDL in treatment groups compared with control group (P≤0.05); but had no significant effects in serum levels of triglyceride, HDL, and VLDL (P>0.05). Conclusions: Probably celery consumption due to the antioxidant properties leads to appropriate changes in serum lipid profiles and reduces them. Therefore it could be useful in the treatment of hyperlipidemia. © 2014 AENSI Publisher All rights reserved

Effect of apium graveolens leaf extract on serum level of thyroid hormones in male rat

BACKGROUND AND OBJECTIVE: Celery (APium graveolens) is a medicinal Plant with antioxidant benefits and rich of flavonoid. Since flavonoids have great imPact on Physiological functions of body and esPecially thyroid function, the aim of this study was to investigate the effect of hydro-alcoholic extract of celery leaf on serum level of thyroid hormones. METHODS: In this exPerimental study, 40 male rats were divided into 5 grouPs of eight rats each. They were control, sham (received normal saline) and the exPerimental grouPs received 1 ml of hydro-alcoholic extract of celery with doses of 50,100 and 200 mg/kg during 21 days by using gavage method. One day after the last gavage, the blood samPles were collected by bloodletting from the heart. After PreParing serum, the level of T3‘T4 and TSH hormones were measured using ELISA method. FINDINGS: The serum levels of T3 (0.95±0.04 and 0.95±0.06, resPectively) and T4 (5.42±0.85 and 5.87±0.89, resPectively) hormones decreased (p0.0 5). CONCLUSION: The results showed that prescribing these doses of celery extracts caused the decrease of thyroid hormone level so it could be considered as a balance hyperthyroidism. © 2014, Babol University of Medical Sciences. All rights reserved