Изучение терапевтических эффектов излучения с длиной волны 670 нм при различных типах диабетического макулярного отека

The purpose of this study was to investigate the therapeutic effects of 670 nm irradiation in patients with diabetic macular edema. In several studies, positive effects of red/near-infrared irradiation showed in a range of ocular diseases such as macular degeneration, macular edema, and retinitis pigmentosa. This study was conducted on forty five eyes of 26 diabetic patients with macular edema between the ages of 51 and 80.Measurement of visual acuity and slit lamp examination, funduscopy, and optical coherence tomography were performed in all subjects. None of the patients had proliferative retinopathy. We used a portable LED device (Warp 10, Quantum Devices) for treatment. Patients held this device at a distance of 3 cm from their eyes for 240 seconds for three months. Full ophthalmic examinations were repeated 1, 2, and 3 months after treatment.After 3 months, the mean visual acuity improved from 0.44 ± 0.38 log MAR to 0.27 ± 0.24 log MAR and vision increased by 1.52 ± 1.16 lines post treatment (р<0.001). The mean central macula thickness decreased from 381.49 ± 144.40 μm to 359.72 ± 128.84 μm (р=0.050). In patients with mild and moderate nonproliferative diabetic retinopathy, the mean central retinal thickness decreased 52.06 ± 67.78 μm and 39.27 ± 44.69 μm, respectively, but patients with severe type showed an increase of 34.93 ± 65.65 μm in the mean central retinal thickness (р<0.001). Also, the severity of macular edema had no effect on final outcomes (р>0.05). Photobiomodulation can positively affect diabetic macular edema, especially in patients with mild to moderate diabetic retinopathy.Целью данной исследовательской работы являлось изучение терапевтических эффектов излучения с длиной волны 670 нм у пациентов с диабетическим макулярным отеком. Ряд предыдущих исследований свидетельствует о положительном эффекте красного инфракрасного излучения при некоторых заболеваниях глаз, таких как макулодистрофия (дегенерация желтого пятна), макулярный отек и пигментный ретинит. Наше исследование было проведено на 45 глазах у 26 больных сахарным диабетом в возрасте от 51 до 80 лет с макулярным отеком. Всем пациентам были проведены определение остроты зрения, осмотр глаз щелевой лампой, фундоскопия и оптическая когерентная томография. Ни у одного из пациентов не было пролиферативной ретинопатии. Для лечения нами был применен портативный светодиодный прибор (Warp 10, Quantum devices). Пациенты держали светодиод на расстоянии 3 см от глаза в течение 240 сек в течение 3 мес. Все офтальмологические исследования были повторены через 1, 2 и 3 мес после проведения лечебной процедуры. Через 3 мес средняя острота зрения улучшилась с показателем логарифма минимального угла разрешения 0,44 ± 0,38 до 0,27 ± 0,24, что показало увеличение показателя остроты зрения на 1,52 ± 1,16 после лечения (р<0,001). Средняя центральная толщина сетчатки в области макулы уменьшилась с 381,49 ± 144,40 мкм до 359,72 ± 128,84 мкм (р=0,050). У пациентов с легкой и умеренной непролиферативной диабетической ретинопатией средняя толщина сетчатки уменьшилась до 52,06 ± 67,78 и 52,06 ± 67,78 мкм, соответственно, а у пациентов с тяжелой ретинопатией наблюдалось увеличение на 34,93 ± 65,65 мкм (р<0,001). Помимо того, степень макулярного отека не повлияла на окончательный результат лечения (р>0,05). Фотобиомодуляция была эффективной при диабетическом макулярном отеке, в частности, у пациентов с легкой и умеренной диабетической ретинопатией

Learning Programming, Syntax Errors and Institution-specific Factors

Learning programming is a road that is paved with mistakes. Initially, novices are bound to write code with syntactic mistakes, but after a while semantic mistakes take a larger role in the novice programmers’ lives. Researchers who wish to understand that road are increasingly using data recorded from students’ programming processes. Such data can be used to draw inferences on the typical errors, and on how students approach fixing them. At the same time, if the lens that is used to analyze such data is used only from one angle, the view is likely to be narrow. In this work, we replicate a previous multi-institutional study by Brown et al. [5]. That study used a large scale programming process data repository to analyze mistakes that novices make while learning programming. In our single institution replication of that study, we use data collected from approximately 800 students. We investigate the frequency, time required to fix, and the development of mistakes through the semester. We contrast our findings from our single institution with the multi-institutional study, and show that whilst the data collection tools and the research methodology are the same, the results can differ solely due to how the course is conducted

Expression of microRNAs in HPV negative tonsil cancers and their regulation of PDCD4

© 2016. Global rates of tonsil cancer have been increasing since the turn of the millennia, however we still have a limited understanding of the genes and pathways which control this disease. This array dataset which is linked to our publication (Zhang et al., 2015) describes the profiling of human miRNAs in tonsil and normal adjacent tissues. With this dataset, we identified a list of microRNA (miRNA) which were highly over represented in tonsil cancers and showed that several miRNAs were able to regulate the tumour suppressor PDCD4 in a temporal manner. The dataset has been deposited into Gene Expression Omnibus (GSE75630)

Pelaksanaan Pembelajaran Menulis Teks Negosiasi pada Siswa SMA Kemala Bhayangkari Kabupaten Kubu Raya

This research aims to analize the running study write text negotiation based on curriculum 2013 on account of the activity introduction, activity core and activities cover. The method used is the method od descriptif. Gathering data was done through observation with the teacher concerned. The technique of gathering data using techniques not directly, the following techniques of observation and technique of the recorder. Whereas, the tool of gathering data is to quide observation and a recorder. Analysis of data the research commencement write text negotiation based on curriculum 2103 on account of the activity introduction, activity core, and the activities cover done by the teacher. Commencement study in the first meeting and the second consist of activities introduction, a core and a cover accomplished according to the beachon the beacon curriculum 2013.evaluation of the done teacher at ameeting of the first and second has load assessment three ranah covering ranah attitude, knowledge, and skills

Keterampilan Menulis Karangan Paragraf Deskripsi dengan Menggunakan Metode Fiel Trip pada Siswa SMP Negeri

This research is motiv ated by the low value of the student's writing, especially in the basic competen ceto conclude the contents ofatext by writing adescription essay. This condition, if no timme diately acted upon, then the impacton the non purpose. In addition, this study also complaints of teachers based on the results ofthe lowpost. Given these problem offers researches a field trip techniques to fooster active learning and student attitudes, which in turn affects the improvement of learning outcome.Based on the description of the back ground research, the problemin this studyas follows.1) How does the teacher plant heir lessonsto improve writing skills by using the me thoddes cription fielftrip? 2) How is the implementation of the method ofteaching writing field trip? 3) Howto writea description of learning out come susing the field trip? The procedur eof this study using action research (PTK) which isimplemen te dastwocy cles. Each cycle consists of four stages : imple mentation, obser vation and reflection.The datain this studyis alesson planning, learning processes, and learning outcomesof students' writing using the field trip. The data wereanalyzed qualitatively with sources that student sand teachers. Based on analysis, it can be conclu dedin creased student learningto writeinevery cycle. The first cycle of the averageob tained was 58 witha percentage of 25% completeness. Cycle both the averageob taine disin creased by 68 or 10 points from the previous cycle and the percentages reaches 40% comple tenes.Based on the result suggestedin the learning process the teacher mustbe able toregu late the allocation of time. Inaccuracyin regulating the allocation of time can cause learning objectives are not fully achieved

Long non-coding RNAs harboring miRNA seed regions are enriched in prostate cancer exosomes

Long non-coding RNAs (lncRNAs) form the largest transcript class in the human transcriptome. These lncRNA are expressed not only in the cells, but they are also present in the cell-derived extracellular vesicles such as exosomes. The function of these lncRNAs in cancer biology is not entirely clear, but they appear to be modulators of gene expression. In this study, we characterize the expression of lncRNAs in several prostate cancer exosomes and their parental cell lines. We show that certain lncRNAs are enriched in cancer exosomes with the overall expression signatures varying across cell lines. These exosomal lncRNAs are themselves enriched for miRNA seeds with a preference for let-7 family members as well as miR-17, miR-18a, miR-20a, miR-93 and miR-106b. The enrichment of miRNA seed regions in exosomal lncRNAs is matched with a concomitant high expression of the same miRNA. In addition, the exosomal lncRNAs also showed an over representation of RNA binding protein binding motifs. The two most common motifs belonged to ELAVL1 and RBMX. Given the enrichment of miRNA and RBP sites on exosomal lncRNAs, their interplay may suggest a possible function in prostate cancer carcinogenesis

Pengaruh Perubahan Penggunaan Lahan terhadap Perubahan Zona Nilai Tanah di Kecamatan Gayamsari Kota Semarang Tahun 2004 dan 2014

Semarang city is the capital of Central Java Province which has 16 districts, one of the districts is Gayamsari. Gayamsari district was growing from year to year, one of caused by increased population growth resulted in the control of utilization or land use which is expected to be able to accommodate the ever growing population activities. Changes in land use and community activities are quite high resulting the value of land in the Gayamsari district is changes. So that research is needed to perform the analysis of land use change on changes in the value of land.This research was originally done by making an initial zone using administrative map of Gayamsari district and Quickbird imagery. Furthermore, the making of maps of land value zone in 2004 and 2014. In the land use maps of 2004 and 2014 have been overlaid, in order to obtain a map of land use changes. At the final stage of the analysis of land use changes to changes in the value of land in Gayamsari district.The results showed the total area of land use change in Gayamsari district in the period 2004 to 2014 was 106 ha. The land-use change occurs on dry land into residential use with an area of 24 ha. While the smallest land-use change occurs in the use of unused land into a trade and services with an area of 0,16 ha. The highest increase in value of land occur on changes of the unused land into a trade and services in the amount of Rp. 1.678.000 per m2. While the lowest increase in value of land occur on changes of the fishpond into unused land is Rp. 44.000 per m2