Primate species richness as a function of rainfall for (A) Southeast Asia; (B) Huxley West; (C) Mainland Southeast Asia; (D) Huxley East; (E) Borneo; and (F) Sumatra.

<p>Note that log-transformed rainfall data are used for (A) to (C) because the data of these three regions are not normally distributed. For comparison purpose, the ranges for all the y-axes are fixed; the rainfall range in the x-axis for (A) to (C) is approximately the same as that for (D) to (E) after log-transformed. The dash and solid fitted trend lines are based on the reduced major axis and the ordinary least squares regressions, respectively.</p

The study area of Southeast Asia and its subdivisions for analysis.

<p>The solid gray line is Huxley’s Line that separates the whole study area into the regions of Huxley East and Huxley West. Within the region of Huxley West, three regions are further analysed, including Mainland Southeast Asia, Borneo, and Sumatra.</p

Regional variation in rainfall and primate species richness.

<p>N: number of sample points; SD: standard deviation.</p

Slope and intercept parameters of the relationships between primate species richness and mean annual rainfall obtained from the reduced major axis (RMA) and the ordinary least squares (OLS) regressions for the six regions analysed in the study.

<p>The correlation coefficient and its square (r and r²) are defined independently of the line fitting criterion and do not differ for RMA and OLS lines <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054995#pone.0054995-Kozak1" target="_blank">[37]</a>. The P values indicate whether the relationships obtained from the OLS regressions are statistically significant.</p>a<p>Logarithm-transformed data used.</p

Additional file 1: of Preventing anxiety problems in children with Cool Little Kids Online: study protocol for a randomised controlled trial

SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) checklist (.doc). Completed SPIRIT 2013 checklist of recommended items to address in a clinical trial protocol and related documents. (DOC 120 kb

Distribution of demographic characteristics and co-morbidities by cases (DHF) and controls (DF) in year 2006 and year 2007–2008 epidemics.

Δ<p>Person's Chi-square, unless otherwise annotated.</p>∧<p>Mann-Whitney U test.</p>#<p>Fisher's Exact test.</p><p>DHF-Dengue hemorrhagic fever.</p><p>DF- Dengue fever.</p><p>DBP- Days before presentation in hospital.</p

Crude and adjusted odds ratios of the association of DHF with age groups, gender and ethnicity in year 2006 and year 2007–2008 epidemics.

*<p>Adjusted odds ratio was obtained from a multivariate logistic regression being adjusted by age groups and ethnicity.</p>**<p>Adjusted odds ratio was obtained from a multivariate logistic regression being adjusted by age groups, gender, ethnicity, diabetes mellitus and hypertension.</p><p>DHF- Dengue Hemorrhagic Fever.</p><p>COR- Crude odds ratio.</p><p>AOR- Adjusted odds ratio.</p><p>CI- Confidence interval.</p

Interaction effect between diabetes mellitus and other comorbidities in year 2007–2008 epidemic.

*<p>Adjusted odds ratio was obtained from a multivariate logistic regression being adjusted by age groups, gender, ethnicity, diabetes mellitus and hypertension.</p><p>DHF- Dengue Hemorrhagic Fever.</p><p>COR- Crude odds ratio.</p><p>AOR- Adjusted odds ratio.</p><p>CI- Confidence interval.</p

Haplotype frequencies of <i>AGTR1</i> SNPs.

<p><i>CI</i> confidence interval, <i>Ctrl</i> control, <i>OR</i> odds ratio, ^aOR estimated odds ratio by R, ^bHaplotypes with total frequencies below 5% in all subjects, ^c<i>P</i> values based on combining results across ethnicities</p

Best fitted gene-gene interaction model.

*<p><i>P</i> values based on 1000 permutations. Analysis of GMDR with adjustment of ethnicity</p