6 research outputs found
Associations between overall, healthful, and unhealthful low-fat dietary patterns and breast cancer risk in a Mediterranean cohort: The SUN project
Objectives: Dietary patterns may have a greater influence on human health than individual foods or nutrients,
and they are also of substantial interest in the field of breast cancer prevention. Beyond the adequate balance
of macronutrients, evidence indicates that the quality of macronutrient sources may play an important role
in health outcomes. We sought to examine the relationship between healthful and unhealthful low-fat
dietary patterns in relation to breast cancer.
Methods: We used observational data from a Mediterranean cohort study (the Seguimiento Universidad de
Navarra project). We prospectively followed 10 930 middle-aged women initially free of breast cancer during
a median follow-up of 12.1 y. We calculated an overall, an unhealthful, and a healthful low-fat diet score,
based on a previously validated 136-item food frequency questionnaire and grouped participants into ter-
tiles. Incident breast cancer—overall and stratified by menopausal status—was the primary outcome. It was
self-reported by participants and confirmed based on medical reports or consultation of the National Death
Index. We used multivariable Cox regression models adjusted for potential confounders.
Results: During 123 297 person-years of follow-up, 150 cases of incident breast cancer were confirmed. No signifi-
cant associations were observed for overall or premenopausal breast cancer. For postmenopausal women, we
observed a significant association for moderate adherence to the unhealthful low-fat dietary score and postmeno-
pausal breast cancer (comparing tertile 2 to tertile 1; hazard ratio = 2.18; 95% confidence interval, 1.15 4.13).
Conclusions: In conclusion, no clear associations were observed, although more research is needed to address
the association between an unhealthful dietary pattern and postmenopausal breast cancer risk
Desarrollo integral en la primera infancia. Cuidado nutricional del niño
Este manual está dividido en 5 etapas de edad: embarazo, 0-6 meses, 6-24 meses, 1-3 años, 1-5 años. En cada etapa habrá información y consejos para cuidar el estado nutricional de su hijo. Todas las recomendaciones de este libro se deben hacer siempre bajo supervisión de un adulto y con previa ayuda y guía de un profesiona
Desarrollo integral en la primera infancia. Cuidado nutricional del niño
Este manual está dividido en 5 etapas de edad: embarazo, 0-6 meses, 6-24 meses, 1-3 años, 1-5 años. En cada etapa habrá información y consejos para cuidar el estado nutricional de su hijo. Todas las recomendaciones de este libro se deben hacer siempre bajo supervisión de un adulto y con previa ayuda y guía de un profesiona
Associations between overall, healthful, and unhealthful low-fat dietary patterns and breast cancer risk in a Mediterranean cohort: The SUN project
Objectives: Dietary patterns may have a greater influence on human health than individual foods or nutrients,
and they are also of substantial interest in the field of breast cancer prevention. Beyond the adequate balance
of macronutrients, evidence indicates that the quality of macronutrient sources may play an important role
in health outcomes. We sought to examine the relationship between healthful and unhealthful low-fat
dietary patterns in relation to breast cancer.
Methods: We used observational data from a Mediterranean cohort study (the Seguimiento Universidad de
Navarra project). We prospectively followed 10 930 middle-aged women initially free of breast cancer during
a median follow-up of 12.1 y. We calculated an overall, an unhealthful, and a healthful low-fat diet score,
based on a previously validated 136-item food frequency questionnaire and grouped participants into ter-
tiles. Incident breast cancer—overall and stratified by menopausal status—was the primary outcome. It was
self-reported by participants and confirmed based on medical reports or consultation of the National Death
Index. We used multivariable Cox regression models adjusted for potential confounders.
Results: During 123 297 person-years of follow-up, 150 cases of incident breast cancer were confirmed. No signifi-
cant associations were observed for overall or premenopausal breast cancer. For postmenopausal women, we
observed a significant association for moderate adherence to the unhealthful low-fat dietary score and postmeno-
pausal breast cancer (comparing tertile 2 to tertile 1; hazard ratio = 2.18; 95% confidence interval, 1.15 4.13).
Conclusions: In conclusion, no clear associations were observed, although more research is needed to address
the association between an unhealthful dietary pattern and postmenopausal breast cancer risk
Dietary Antioxidant Vitamins and Minerals and Breast Cancer Risk: Prospective Results from the SUN Cohort
There is growing interest in natural antioxidants and their potential effects on breast cancer (BC). Epidemiological evidence, however, is inconsistent. We prospectively evaluated the association between dietary intake of vitamins A, C, and E, selenium, and zinc and BC among 9983 female participants from the SUN Project, a Mediterranean cohort of university graduates. Participants completed a food frequency questionnaire at baseline, and biennial follow-up information about incident BC diagnosis was collected. Cases were ascertained through revision of medical charts and consultation of the National Death Index. Cox proportional hazards models were used to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CI). During an average follow-up of 11.3 years, 107 incident BC cases were confirmed. The multivariable HRs (95% CI) for BC comparing extreme tertiles of energy-adjusted dietary intakes were 1.07 (0.64–1.77; Ptrend = 0.673) for vitamin A, 1.00 (0.58–1.71; Ptrend = 0.846) for vitamin C, 0.92 (0.55–1.54; Ptrend = 0.728) for vitamin E, 1.37 (0.85–2.20; Ptrend = 0.135) for selenium, and 1.01 (0.61–1.69; Ptrend = 0.939) for zinc. Stratified analyses showed an inverse association between vitamin E intake and postmenopausal BC (HRT3 vs. T1 = 0.35; 95% CI, 0.14–0.86; Ptrend = 0.027). Our results did not suggest significant protective associations between dietary vitamins A, C, and E, selenium, or zinc and BC risk
Adherence to the 2018 world cancer research fund/american institute for cancer research recommendations and breast cancer in the SUN project
A proportion of breast cancer cases are attributable to combined modifiable risk factors. The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) has recently updated the recommendations for cancer prevention and a standard scoring system has been published. The aim of this study was to evaluate the association between compliance with the 2018 WCRF/AICR cancer prevention recommendations (Third Expert Report) and the risk of breast cancer in the SUN ("Seguimiento Universidad de Navarra") prospective cohort. Spanish female university graduates, initially free of breast cancer, were included (n = 10,930). An 8-item score to measure compliance to the recommendations was built: body fat, physical activity, consumption of wholegrains/vegetables/fruit/beans, "fast foods", red/processed meat consumption, sugar-sweetened drinks consumption, alcohol intake, and breastfeeding. A stratified analysis was conducted according to menopausal status. A non-significant inverse association was observed for overall breast cancer. The inverse association became statistically significant for post-menopausal breast cancer after multivariable adjustment (hazard ratio for > 5 vs. ≤ 3 points = 0.27; 95% CI: 0.08-0.93). The results suggested that the possible inverse association with breast cancer was attributable to the combined effects of the different nutritional and lifestyle components