Polystyrene-supported organocatalysts for alfa-selenenylation and Michael reactions. A common post-modification approach for catalytic differentiation

Three different resin-supported catalysts have been prepared by using the well established post-modification approach by means of thiol-ene coupling reaction. Two catalysts were tested for the first time in the asymmetric \u3b1-selenenylation of propanal, while the third catalyst was used in the Michael addition reaction. While the preliminary results are not encouraging in the case of supported J\uf8rgensen\u2019 catalyst, interesting data have been collected with both for the supported MacMillan and prolyl-prolinol catalysts. In fact, these catalysts displayed good activity and selectivity. A reversed enantioselectivity in the \u3b1-selenenylation was observed by changing the polarity of the solvent. Finally, these materials were easily recovered, and used four and five times, respectively

Sali di imidazolio multistrato supportati covalentemente: attività catalitica per la produzione di carbonati ciclici in scCO2 e nuovi supporti per catalizzatori di palladio

I liquidi ionici supportati (SILP) hanno trovato interessanti applicazioni sia nel campo delle reazioni catalizzate da metalli che in organocatalisi [1]. Inoltre, i SILP sono stati efficacemente impiegati in reazioni di apertura di epossidi in CO2 supercritica per fornire carbonati ciclici [2]. I liquidi ionici vengono generalmente supportati covalentemente attraverso la modificazione dei gruppi funzionali presenti sulla superficie del supporto, conducendo in tal modo alla formazione di un monostrato di liquido ionico supportato. Gli esempi di SILP legati covalentemente, in maniera tale da ottenere dei multistrato, sono rari. In questa comunicazione viene riportato un metodo per preparare dei sali di imidazolio supportati covalentemente e il loro impiego come: a) catalizzatori riciclabili per la reazione di epossidi con CO2 supercritica per fornire carbonati ciclici, e b) supporti per nanoparticelle di palladio e l’impiego di tali materiali come catalizzatori riciclabili per la reazione di Suzuki in ambiente acquoso fra acidi boronici e bromuri arilici

Cystic Fibrosis assessment in infertile couples: genetic analysis trough the Next Generation Sequencing technique

Background: Cystic Fibrosis (CF) is a genetic disease which is responsible for different systemic conditions. In particular, CF could be responsible for infertility, especially in the male partner due to congenital bilateral absence of vas deferens (CBAVD). Moreover, in Assisted Reproductive Techniques CF screening is performed in order to detect possible risks for the newborn. For this reason, CF testing is one of the main genetic screening performed in infertile couples. Methods: In this scenario, we present a prospective observational study in CF testing with Next Generation Sequencing (NGS) technique on 360 subjects referring to an In-Vitro Fertilization center. Results: 360 subjects were screened for CFTR. Of them, 19 subjects presented CF causing variants, 44 subjects presented CFTR-RD associated, 22 subjects had variants of uncertain significance and 19 subjects with no clinical consequences. Conclusion: Results clarify proportions of the main CF mutations. Actually, there are no more advanced techniques rather than Next Generation Sequencing (NGS) technique, although it is not yet widely used as a test for the identification of the CF carrier