T1 MRI superimposition showing the cluster of voxels in the right parahippocampal gyrus (BAs 34 and 28) in which 18F-FDG uptake was significantly higher at PET0 (n = 8) as compared to PET1 (n = 8) (on the left sagittal and on the right coronal projections).

<p>Coordinates and regional details are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057596#pone-0057596-t001" target="_blank">Table 1</a>.</p

T1 MRI superimposition showing the cluster of voxels in the superior temporal gyrus (BA 38) in which 18F-FDG uptake was significantly higher at PET0 (n = 8) as compared to PET1 (n = 8) (on the left sagittal and on the right coronal projections).

<p>Coordinates and regional details are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057596#pone-0057596-t001" target="_blank">Table 1</a>.</p

Hystogram showing the values of the three tests scores and the metabolism in the cluster of voxels showing statistically significant hypometabolism at PET0 as compared to PET1 (A) and viceversa (B).

<p>The mean of glucose metabolism values in the eight patients are expressed as percent of the values found in cerebellum.</p

Numerical results of SPM comparisons between ¹⁸F-FDG uptake in PET0 (n = 8) and PET1 (n = 8).

<p>A value of p≤0.001, corrected for multiple comparison at cluster level, was accepted as statistically significant. In the ‘cluster level’ section on left, the number of voxels, the corrected p value of significance and the cortical region where the voxel is found, are all reported for each significant cluster. In the ‘voxel level’ section, all of the coordinates of the correlation sites (with the Z-score of the maximum correlation point), the corresponding cortical region and BA are reported for each significant cluster. L, left; R, right; BA, Brodmann’s area. In the case that the maximum correlation is achieved outside the grey matter, the nearest grey matter (within a range of 3×mm) is indicated with the corresponding BA.</p

Mean and standard deviations of patients scores in the questionnaires on Balance (Gomez-Alvarez and Jauregui-Renaud, 2011), Anxiety (Zung, 1971), and Depersonalization/Derealization scales (Dep/Der, Cox and Swinson, 2002) at PET0 and PET1.

<p>Mean and standard deviations of patients scores in the questionnaires on Balance (Gomez-Alvarez and Jauregui-Renaud, 2011), Anxiety (Zung, 1971), and Depersonalization/Derealization scales (Dep/Der, Cox and Swinson, 2002) at PET0 and PET1.</p

Linear regression of C3 predicting ISI.

<p>Linear regression of C3 predicting ISI.</p

General characteristics of the study population.

<p>General characteristics of the study population.</p

Metabolic characteristics of the study population.

<p>Metabolic characteristics of the study population.</p