Effects of PAβN on the MIC values of tested NSAIDs against clinical isolates of <i>Enterobacteriaceae</i> and non-fermentative Gram-negative rods.

<p>Effects of PAβN on the MIC values of tested NSAIDs against clinical isolates of <i>Enterobacteriaceae</i> and non-fermentative Gram-negative rods.</p

The activity of NSAIDs (active substances and medicinal products) with and without the efflux pump inhibitor PAβN against standard Gram-negative strains.

<p>The activity of NSAIDs (active substances and medicinal products) with and without the efflux pump inhibitor PAβN against standard Gram-negative strains.</p

Effects of acetylsalicylic acid and its metabolites on the susceptibility of Gram-negative clinical strains (12 isolates of each species) to quinolones in the presence or absence of PAβN.

<p>Effects of acetylsalicylic acid and its metabolites on the susceptibility of Gram-negative clinical strains (12 isolates of each species) to quinolones in the presence or absence of PAβN.</p

Susceptibility of clinical strains of Gram-negative rods to selected antimicrobial agents in the presence or absence of PAβN.

<p>Susceptibility of clinical strains of Gram-negative rods to selected antimicrobial agents in the presence or absence of PAβN.</p

The activity of NSAIDs and paracetamol (active substances and medicinal products) against clinical isolates of <i>Enterobacteriaceae</i> and non-fermentative Gram-negative rods.

<p>The activity of NSAIDs and paracetamol (active substances and medicinal products) against clinical isolates of <i>Enterobacteriaceae</i> and non-fermentative Gram-negative rods.</p

The presence of β-lactamases in bacterial culture supernatants as visualized by the nitrocefin hydrolysis test.

<p>The presence of β-lactamases in bacterial culture supernatants as visualized by the nitrocefin hydrolysis test.</p

Influence of PAβN on the increase of susceptibility to cephalosporins in <i>P. aeruginosa</i> PAO1161 transformants.

<p>Influence of PAβN on the increase of susceptibility to cephalosporins in <i>P. aeruginosa</i> PAO1161 transformants.</p

The effect of PAβN on the susceptibility to cephalosporins of clinical isolates of ESβL-positive <i>Enterobacteriaceae</i>.

<p>The effect of PAβN on the susceptibility to cephalosporins of clinical isolates of ESβL-positive <i>Enterobacteriaceae</i>.</p

The effect of PAβN on the susceptibility to cephalosporins of clinical isolates of ESβL-positive <i>P. aeruginosa</i>.

<p>The effect of PAβN on the susceptibility to cephalosporins of clinical isolates of ESβL-positive <i>P. aeruginosa</i>.</p

Benzosiloxaboroles: Silicon Benzoxaborole Congeners with Improved Lewis Acidity, High Diol Affinity, and Potent Bioactivity

The synthesis and physicochemical properties of benzosiloxaboroles, the silicon analogues of an important class of heterocyclic compoundsbenzoxaborolesis presented. They were prepared by halogen–lithium exchange reactions of (2-bromophenyl)­boronates with <i>n</i>-BuLi followed by the silylation or boronation of (2-lithiophenyl)­dimethylsilanes. The cyclization of the resulting 2-(dimethylsilyl)­phenylboronates apparently occurs through intramolecular dehydrogenative cyclization reaction in the presence of water. Unlike the case for benzosiloxaborole, the formation of its analogue containing a thiophene ring is thermodynamically unfavorable, which was confirmed by theoretical calculations. The presence of a B–O–Si linkage results in increased Lewis acidity with respect to the analogous benzoxaboroles. The acidity is strongly enhanced by fluorination or introduction of phenyl groups at the silicon atom. Selected compounds show good antifungal activity, and thus they are potential small-molecule therapeutic agents. They can also serve as effective receptors for biologically relevant diols under neutral pH conditions