Early-stage entrepreneurial aspirations in efficiency-driven economies

The aim of this article is to identify the influencing factors of early-stage entrepreneurial aspirations in efficiency-driven economies based on Global Entrepreneurship Monitor (GEM) Adult Population Survey (APS) database for the year 2008. Within the entrepreneurial aspirations the innovativeness of entrepreneurial businesses and the job growth expectations were studied.early-stage entrepreneur, entrepreneurial aspirations, Global Entrepreneurship Monitor.

EXPERIENCIA Y RESULTADOS DEL CURSO DE CAPACITACION SEMIPRESENCIAL SENSORES Y REDES DE SENSORES

El desarrollo tecnológico acelerado y la creciente demanda de mantener la formación continua y actualizada de los egresados universitarios y profesionales de las empresas cubanas, unida a la necesidad de impulsar las actividades de investigación, han motivado el diseño e implementación de este curso de capacitación sustentado en el uso de ambientes virtuales. El curso de capacitación profesional Sensores y Redes de Sensores fue impartida para las empresas del Grupo de Electrónica en la modalidad de curso a distancia, síncrona, semipresencial. Este articulo brinda información sobre los procedimientos de coordinación previa, preparación metodológica y elaboración de los contenidos. La evaluación del curso se realizó a través de mini proyectos tutorizados con seguimiento asíncrono. La defensa de los trabajos fue presencial frente a un tribunal integrado por los profesores del curso, permitiendo otorgar calificaciones individuales. Las nuevas experiencias prácticas  ̶ adquiridas y aquí presentadas ̶  en el uso de los modelos de enseñanza no presencial o semipresencial son de interés actual, siendo estos modelos cada vez más extendidos en la formación de los recursos humanos de las empresas cubanas

Preparing Special Educators to Assume Collaborative and Consultative Roles

The incidence of children with disabilities is growing in both the private and public school sectors. As a result of this trend and efforts to place children in inclusive settings, there is an increasing need for special educators who can provide instruction within the context of a regular education classroom, develop individualized education plans (IEPs), support parents, and be consultants to teachers on behalf of children. The consultative special education teacher will be increasingly in demand in the future if children with disabilities are to be successfully included in public, private, and Catholic schools. The Catholic University of America utilizes a consultative, collaborative model for preparing Master’s candidates in its special education program. The results of the first 4 years of this program demonstrate that the candidates in this program have acquired the knowledge, skills, and dispositions that are needed to be effective consultative, collaborative special educators in the field. This article provides a detailed description of the elements that make up this personnel preparation program. Particular focus is placed on the skills and knowledge to carry out consultative planning, including a rubric to evaluate the candidates’ performance. The article offers guidance to universities who may choose to create special education programs that prepare consultative special educators

Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster.

Autophagy, a lysosomal self-degradation and recycling pathway, plays dual roles in tumorigenesis. Autophagy deficiency predisposes to cancer, at least in part, through accumulation of the selective autophagy cargo p62, leading to activation of antioxidant responses and tumor formation. While cell growth and autophagy are inversely regulated in most cells, elevated levels of autophagy are observed in many established tumors, presumably mediating survival of cancer cells. Still, the relationship of autophagy and oncogenic signaling is poorly characterized. Here we show that the evolutionarily conserved transcription factor Myc (dm), a proto-oncogene involved in cell growth and proliferation, is also a physiological regulator of autophagy in Drosophila melanogaster. Loss of Myc activity in null mutants or in somatic clones of cells inhibits autophagy. Forced expression of Myc results in cell-autonomous increases in cell growth, autophagy induction, and p62 (Ref2P)-mediated activation of Nrf2 (cnc), a transcription factor promoting antioxidant responses. Mechanistically, Myc overexpression increases unfolded protein response (UPR), which leads to PERK-dependent autophagy induction and may be responsible for p62 accumulation. Genetic or pharmacological inhibition of UPR, autophagy or p62/Nrf2 signaling prevents Myc-induced overgrowth, while these pathways are dispensable for proper growth of control cells. In addition, we show that the autophagy and antioxidant pathways are required in parallel for excess cell growth driven by Myc. Deregulated expression of Myc drives tumor progression in most human cancers, and UPR and autophagy have been implicated in the survival of Myc-dependent cancer cells. Our data obtained in a complete animal show that UPR, autophagy and p62/Nrf2 signaling are required for Myc-dependent cell growth. These novel results give additional support for finding future approaches to specifically inhibit the growth of cancer cells addicted to oncogenic Myc