2 research outputs found
In vivo evaluation of antiplasmodial activity of hydroethanolic stem extract of Baphia pubescens in Plasmodium berghei infected albino mice
Introduction: Malaria is a global concern especially with the emergence of multidrug resistant
strains of Plasmodium falciparum. The need exist for newer and effective antimalarial agents.
Hydroethanolic stem extract of Baphia pubescens has been used for the treatment of malaria in
traditional medical settings. This study explores the antimalarial potential of this extract.
Methods: The lethal dose of hydroethanolic stem extracts of B. pubescens was determined.
Phytochemical screening of the extract was done using standard methods. Experimental animals
received graded doses of the extract once daily for 3 days. In vivo antiplasmodial activity was
assessed by the Rane’s curative test, using P. berghei infected mice.
Results: The extract demonstrated a dose-dependent curative activity at the tested doses (100, 200
and 400 mg/kg). Complete (100%) parasite clearance was achieved (on day 4 post-treatment) at 400
mg/kg dose, which is greater than the standard drug used (artemether-lumefantrine). The extract
is considered safe since the lethal dose was higher than 5000 mg/kg.
Conclusion: This study demonstrated that hydroethanolic extracts of B. pubescens has promising
antimalarial activity. This supports the local use of B. pubescens as an anti-malarial agent. Further
studies need to be done to identify and characterize the active principles/substances in the extract
Integration of LaTeX formula in computer-based test application for academic purposes
LaTeX is a free document preparation system that handles the typesetting of
mathematical expressions smoothly and elegantly. It has become the standard
format for creating and publishing research articles in mathematics and many
scientific fields. Computer-based testing (CBT) has become widespread in recent
years. Most establishments now use it to deliver assessments as an alternative
to using the pen-paper method. To deliver an assessment, the examiner would
first add a new exam or edit an existing exam using a CBT editor. Thus, the
implementation of CBT should comprise both support for setting and
administering questions. Existing CBT applications used in the academic space
lacks the capacity to handle advanced formulas, programming codes, and tables,
thereby resorting to converting them into images which takes a lot of time and
storage space. In this paper, we discuss how we solvde this problem by
integrating latex technology into our CBT applications. This enables seamless
manipulation and accurate rendering of tables, programming codes, and equations
to increase readability and clarity on both the setting and administering of
questions platforms. Furthermore, this implementation has reduced drastically
the sizes of system resources allocated to converting tables, codes, and
equations to images. Those in mathematics, statistics, computer science,
engineering, chemistry, etc. will find this application useful.Comment: 4 figure