A comparison of spot urinary protein-creatinine ratio with 24-hour urine protein in quantification of proteinuria in women with hypertensive disorders of pregnancy

Background: Proteinuria is a major indicator of hypertensive disorder of pregnancy. The gold standard for diagnosis of significant proteinuria is based on a 24hour urine collection which is cumbersome, time-consuming, and inconvenient to patients. A need, therefore, exists for a rapid, valid, and accurate test to identify significant urinary proteinuria. Methods: We conducted an observational cross-sectional hospital-based study wherein a total of 150 pregnant women who met the criteria of preeclampsia were taken. Spot urine samples for calculating the urine P/C ratio were taken immediately before 24hr urine collection. Correlation between 24hour urine protein and spot PCR was then determined by Pearson’s correlation coefficient(r). Results: The correlation coefficient (r) between 24hr urine protein and spot PCR was found to be 0.734 (n=150) which was highly significant with p<0.001. In this study, population the ROC curve analysis revealed the sensitivity of 90.3% and specificity of 97.3% with AUC 0.958 for a cut-off value of spot PCR as 0.43 to detect significant. Conclusions: Spot PCR is an accurate, valid, steady fast, reliable, and time-saving test which may be used as an alternative method for determining significant proteinuria in patients with pregnancy-induced hypertension

Adaptive Replication and Access Control of Multimedia Data in a P2P Environment

This paper explores some of the ideas and solutions related to replication and access control of multimedia data in a hierarchical P2P environment. We provided overview of the techniques to generate multiresolution of multimedia data and explored error recovery and access control issues

RECENT ADVANCEMENT, TECHNOLOGY & APPLICATIONS OF MULTIPLE EMULSIONS

Multiple emulsions are complex polydispersed systems where both oil in water and water in oil emulsion exists simultaneously which are stabilized by lipophilic and hydrophilic surfactants respectively. The ratio of these surfactants is important in achieving stable multiple emulsions. Among water-in-oil-in-water (w/o/w) and oil-in-water-in-oil (o/w/o) type multiple emulsions, the former has wider areas of application and hence are studied in great detail. Formulation, preparation techniques and in vitro characterization methods for multiple emulsions are reviewed. Various factors affecting the stability of multiple emulsions and the stabilization approaches with specific reference to w/o/w type multiple emulsions are discussed in detail. Favorable drug release mechanisms and/or rate along with in vivo fate of multiple emulsions make them a versatile carrier. It finds wide range of applications in controlled or sustained drug delivery, targeted delivery, taste masking, bioavailability enhancement, enzyme immobilization, etc. Multiple emulsions have also been employed as intermediate step in the microencapsulation process and are the systems of increasing interest for the oral delivery of hydrophilic drugs, which are unstable in gastrointestinal tract like proteins and peptides. With the advancement in techniques for preparation, stabilization and rheological characterization of multiple emulsions, it will be able to provide a novel carrier system for drugs, cosmetics and pharmaceutical agents. In this review, emphasis is laid down on formulation, stabilization techniques and potential applications of multiple emulsion system

Proposal and Validation of Usability Model for Component Based Software System

Increasing demand of rapid and cost effective development of software system has increased the demand of Component Based Software Engineering (CBSE). In CBSE, software system is developed by using existing components. These components can be in-house components or third party components. To develop a Component Based Software System (CBSS), it is important to select the suitable component in such a manner that the components of the software system do not affect each other. To increase the acceptance of the CBSS among the users and the market value of the software industries, it is important to increase the usability of the CBSS. Several usability models have been proposed for traditional and object-oriented software system (OOSS), but there is no usability model for CBSS. Existing traditional and object-oriented models can’t be perfectly suitable for CBSS because of the unique characteristics of the components. This paper presents a usability model (UMCBSS) for CBSS. The proposed usability model is based on most significant usability factors. These factors are analysed from CBSS quality models. With the help of proposed model, usability is evaluated by using two different techniques i.e., centroid method and bisector method in MATLAB. Experimental results are also validated by using Center of Gravity (COG) and Mean-Max method. With the help of the proposed model, developers of the CBSS will be able to measure the usability of CBSS and to remove the usability flaws from the software system