Tubercular dactylitis with deformity ipsilateral involvement of hand and foot in an adult: a case report

Tubercular dactylitis is a rare entity and usually involves bones of hands and feet, involvement of feet is less common. Here we report case of 18 years old female with neglected tubercular involvement of her left thumb and left great toe of foot with hallux varus deformity. Her diagnosis was delayed as she did not seek any healthcare advice for a long time and also lack of suspicion of entity. This entity which should be kept in mind when making differential diagnosis that can be treated conservatively when diagnosed early

Opterećenje tekućinom i prijenosna sposobnost bubrega u dvogrbe deve u dehidraciji i rehidraciji zimi i ljeti

The effect of dehydration and rehydration was studied during winter and summer on solute loads and transfer function of kidney in healthy adult female dromedary camels. Kidney solute loads (KSLs) which included plasma loads (PL) and tubular loads (TL) were determined for glucose, proteins, urea, creatinine, sodium, potassium, chloride, calcium and phosphorus. The dehydration period was of 24 days in winter and 13 days in summer. Water was provided ad libitum during control and rehydration periods and was restricted completely during dehydration period. The mean value of TFK during summer control was significantly (P≤0.05) lower than that in winter control. In winter the mean values of TFK during rehydration phases differed significantly (P≤0.05) from control values. A similar trend was observed during summer, except that the calculations for TFK could not be made at hour ½ and at hour 2 of rehydration since animals did not void urine. During dehydration periods in both seasons PL and TL mean values decreased significantly (P≤0.05) from respective control mean values. It was concluded that during dehydration reduction in kidney solute loads was indicative of the water conservation ability of camels because reduced plasma loads and tubular loads resulted in trapping of constituents in the plasma to hold more water.Istražen je učinak dehidracije i rehidracije u tijeku zime i ljeta na opterećenje tekućinom i prijenosnu sposobnost bubrega u zdravih ženki dvogrbe deve. Opterećenje obuhvaća plazmalno (PO) i tubularno (TO) opterećenje, a određivano je za glukozu, bjelančevine, mokraćevinu, kreatinin, natrij, kalij, klor, kalcij i fosfor. Razdoblje dehidracije trajalo je 24 dana zimi i 13 dana ljeti. Životinje su po volji pile vodu tijekom kontrolnoga i rehidracijskoga razdoblja, ali vodu nisu dobivale u tijeku dehidracijskoga razdoblja. Srednja vrijednost prijenosne sposobnosti bubrega u tijeku ljetnih mjeseci bila je značajno niža (P≤0,05) u odnosu na zimsko kontrolno razdoblje. Zimi su se srednje vrijednosti prijenosne sposobnosti bubrega za vrijeme rehidracije značajno razlikovale u odnosu na kontrolne vrijednosti (P≤0,05). Sličan je trend zabilježen ljeti, osim što izračuni nisu mogli biti učinjeni sat i pol te dva sata nakon rehidracije, jer životinje nisu izlučivale mokraću. Srednje vrijednosti PO i TO bile su značajno manje u odnosu na kontrolu (P≤0,05) u tijeku dehidracijskoga razdoblja u oba godišnja doba. Zaključuje se da je smanjeno opterećenje bubrega u tijeku dehidracije dobar pokazatelj sposobnosti čuvanja vode s obzirom na to da smanjeno plazmalno i tubularno opterećenje dovodi do zadržavanja sastojaka u plazmi koji imaju sposobnost osmotskoga zadržavanja vode

Synthesis Approach of 2D Mesh Network Inter Communication (2D-2D) using Network on Chip

The solution for the multiprocessor system architecture is Application specific Network on Chip (NOC) architectures which are emerging as a leading technology. Modeling and simulation of multilevel network structure and synthesis for custom NOC can beneficial in addressing several requirements such as bandwidth, inter process communication, multitasking application use, deadlock avoidance, router structures and port bandwidth. The paper emphasizes on the network on chip modeling and synthesis of 2D network and intercommunication among multilevel 2D networks. NOC synthesis environment provides transaction level network modeling and address all the requirements together in an integrated chip. In the paper consideration is done for 2D, 8 x 8 network and similar networks are considered which are identified by their specific network address. NOC chip is developed using VHDL programming language. Design is implemented in Xilinx 14.2 VHDL software, functional simulation is carried out in Modelsim 10.1 b, student edition and synthesis process is carried out on Digilent Sparten -3E FPGA

Study of effect of diabetes mellitus on classical risk factors for coronary artery disease

Background: Diabetes mellitus (DM) is increasingly prevalent in general population and is associated with increased risk for coronary artery disease (CAD). DM both directly and indirectly increases risk of CAD. Quantum of DM associated increase in classical risk factor for CAD is not exactly described. In present study, association of traditional risk for CAD and DM was analyzed.Methods: Total 150 patients with CAD were enrolled and divided into two group: group 1 with DM (84 patients) and group 2 without DM (66 patients). These two were compared and analyzed for classical risk factors for DM.Results: CAD with DM group had higher prevalence for traditional risk for CAD than CAD alone group: for Hypertension relative prevalence was 67.8 and 36.3% respectively (p<0.05); for Obesity it was 79.7 and 40.9% respectively (p<0.05) and for Dyslipidemia relative prevalence was 75 and 37.8% respectively (p<0.05).Conclusions: DM is major risk for CAD and it is also associated with increased prevalence for hypertension, obesity and dyslipidemia in affected population

Synthesis, antiviral and contraceptive activities of nucleoside–sodium cellulose sulfate acetate and succinate conjugates

Chemical conjugates between sodium cellulose sulfate (CS), displaying contraceptive and HIV-entry inhibiting properties, and nucleoside reverse transcriptase inhibitors (NRTIs) (3′-azido-2′,3′-dideoxythymidine (AZT), 3′-fluoro-2′,3′-dideoxythymidine (FLT), or 2′,3′-dideoxy-3′-thiacytidine (3TC)) were designed to simultaneously provide contraceptive and anti-HIV activity. Two linkers, acetate and succinate, were used to conjugate the nucleoside analogs with CS. The conjugates containing cellulose sulfate-acetate (CSA) (e.g., AZT–CSA and FLT–CSA) were found to be more potent than CS and other conjugates (e.g., AZT–succinate–CS, and FLT–succinate–CS). The presence of both sulfate and the acetate groups on cellulose were critical for generating maximum anti-HIV activity. In addition to showing equal potency against wild-type and multidrug resistant HIV-1, the AZT–CSA conjugate displayed significant contraceptive activity in an animal model, providing the initial proof-of-concept for the design and synthesis of dual-activity compounds based on these combinations. [Refer to PDF for graphical abstract

RFID Based Automatic Shopping Cart

Large grocery stores are nowadays used by millions of people for the acquisition of an enlarging number of products. Product acquisition represents a complex process that comprises time spent in corridors, product location and checkout queues. On the other hand, it is becoming increasingly difficult for retailers to keep their clients loyal and to predict their needs due to the influence of competition and the lack of tools that discriminate consumption patterns. In this article it is presented the proposal of an architecture and solution of an innovative system for the acquisition of products in grocery stores (Intelligent Cart). The Intelligent Cart explores emerging mobile technologies and automatic identification technologies (such as RFID) as a way to improve the quality of services provided by retailers and to augment the consumer value thus allowing to save time and money. Keywords: Automatic Product Identification; Electronic Services; Grocery Stores, RFID, Intelligent car

Synthesis and in Vitro Characterization of Novel Dextran–Methylprednisolone Conjugates with Peptide Linkers: Effects of Linker Length on Hydrolytic and Enzymatic Release of Methylprednisolone and its Peptidyl Intermediates

To control the rate of release of methylprednisolone (MP) in lysosomes, new dextran–MP conjugates with peptide linkers were synthesized and characterized. Methylprednisolone succinate (MPS) was attached to dextran 25 kDa using linkers with 1–5 Gly residues. The release characteristics of the conjugates in pH 4.0 and 7.4 buffers, blood, liver lysosomes, and various lysosomal proteinases were determined using a size-exclusion and/or a newly developed reversed-phase HPLC method capable of simultaneous quantitation of MP, MPS, and all five possible MPS-peptidyl intermediates. We synthesized conjugates with ≥90% purity and 6.9–9.5% (w/w) degree of MP substitution. The conjugates were stable at pH 4.0, but released MP and intact MPS-peptidyl intermediates in the pH 7.4 buffer and rat blood, with faster degradation rates for longer linkers. Rat lysosomal fractions degraded the conjugates to MP and all the possible intermediates also at a rate directly proportional to the length of the peptide. Whereas the degradation of the conjugates by cysteine peptidases (papain or cathepsin B) was relatively substantial, no degradation was observed in the presence of aspartic (cathepsin D) or serine (trypsin) proteinases, which do not cleave peptide bonds with Gly. These newly developed dextran conjugates of MP show promise for controlled delivery of MP in lysosomes

Vertical Transmission of Chikungunya virus in Aedes aegypti Mosquitoes from Northern India

Chikungunya virus is now recognised as a resurging arbovirus of global public health significance, with their circulation in both new and old world. It is horizontally transmitted among vertebrates by Aedes mosquitoes. So far, the existence of vertical transmission of Chikungunya virus in Aedes vector is riddled with conflicting reports. In this study, presence of Chikungunya virus was detected in adult Aedes aegypti mosquitoes that emerged from field-collected larvae from Gwalior, northern India during 2010. This was further confirmed through nucleotide sequencing that revealed the presence of novel east central south African (ECSA) genotype of Chikungunya virus. This provides molecular evidence for vertical transmission of Chikungunya virus in mosquitoes in nature, which may have important consequences for viral survival during inter-epidemic period and adverse climatic conditions