Pulmonary Performance In Asymptomatic Young Nigerian Population Following The Administration Of Ascorbic Acid And Salbutamol

The relationship between vitamin C and pulmonary function has been reported to be a protection against pulmonary dysfunction. Sympathomimetics like salbutamol are respiratory smooth muscle relaxants. This study is aimed at investigating the roles of vitamin C and salbutamol on pulmonary function in a Nigerian population. Undergraduate medical students who gave their informed consent were clinically screened and thirty (30) selected. The subjects were grouped, and given Ascorbic acid and Salbutamol. Spirometry and peak flow measurements were done on each subject. Ascorbic acid was given orally at a dose of 1.50 mg /kg body weight; and salbutamol at a dose of 70 μg/kg body weight, orally. Measurements were taken an hour after each administration of the drugs. Results show mean PEFR in male and female control as 485.76 ± 51.40 L/min, and 329.87 ± 34.90 L/min respectively. Ascorbic acid increases PEFR much more than salbutamol VT, ERV, IC, VC and IRV were increased by ascorbic acid while Salbutamol decreased ERV, IC, VC and IRV. The study supports the performance enhancing role of ascorbic acid, more pronounced in the males than females. There do not seem to be any beneficial roles of salbutamol in asymptomatic individuals. Key words: Lung function, Ascorbic acid, Salbutamol Nigerian Journal of Physiological Sciences Vol.19(1&2) 2004: 48-5

Stroke in persons with diabetes mellitus in Jos, Nigeria

No Abstract. Nigerian Journal of Medicine Vol. 15(3) July-September 2006: 215-21

Pattern of Childhood Renal Diseases in Jos, Nigeria: A Preliminary Report

Background: Childhood kidney diseases remain important causes of significant morbidity and mortality in Nigeria. This is characterized by late presentation, missed diagnosis in certain cases and failure to offer renal replacement therapy to many renal failure patients who required it.Methodology: This was a retrospective study of children managed at the Jos University Teaching Hospital Jos, Nigeria, over a three- year period.Results: Acute glomerulonephritis (AGN) was the commonest renal disease (37.7%). Other conditions included chronic renal failure (20.3%), nephrotic syndrome (16%), urinary tract infection (11.6%), nephroblastoma(7.2%), hemolytic uremic syndrome (5.3%) and polycystic kidney disease (1.5%). The commonest complication of AGN was hypertensive encephalopathy. Chronic glomerulonephritis was the commonest cause of CRF (50%).Conclusions: AGN is the most common childhood renal disease in Jos, Nigeria. Improved socioeconomic and environmental conditions are needed in Nigeria to reduce the incidence of preventable renal diseases

Serum Lipids In Pre Dialysis Chronic Renal Failure Patients In Jos University Teaching Hospital, Nigeria

A prospective study of serum lipids in pre dialysis chronic renal failure (CRF) patients in the Jos university teaching hospital over a twelve month period undertaken to determine the pattern of lipid abnormalities associated with this disease. Lipids were measured in the fasting state using standard methods in 67 patients with CRF and 50 healthy controls. The means of total cholesterol and triglyceride were similar in both groups. The mean HDL cholesterol was significantly lower in the study group compared to controls; being 1.72+ 1.34 mmol/L and 4.21+ 1.89 mmol/L respectively (df= 1, F= 83.78, p < 0.001), while LDL cholesterol was significantly higher in the study group compared to controls (2.90+ 1.56 mmol/L vs. 1.87+ 1.00 mmol/L; df= 1, F= 16.99,

Hypertension In Type II Diabetes Mellitus In Jos University Teaching Hospital, Jos, Nigeria

Objectives: We assessed 85 patients with type II diabetes mellitus to determine the proportion of hypertension in accordance with WHO criteria. Other clinical parameters such as fundoscopic examination and urinalysis were carried out. Methods: A cross-sectional study of hypertension in type II diabetic patients in Jos University Teaching Hospital, Jos, Nigeria Results: Forty-two of the patients were hypertensive with only 28 (32.9%) previously diagnosed and were on treatment. Age of patient, duration of diabetes and diabetic retinopathy were significantly associated with hypertension in diabetes. Conclusion: Hypertension is commoner in diabetes in sub-saharan Africa that it was previously believed. The finding of hypertension should arouse the possibility of the presence of microangiopathic complications in type II diabetes. Highland Medical Research Journal Vol.1(2) 2002: 22-2

Maternal and neonatal outcomes after caesarean delivery in the African Surgical Outcomes Study: a 7-day prospective observational cohort study.

BACKGROUND: Maternal and neonatal mortality is high in Africa, but few large, prospective studies have been done to investigate the risk factors associated with these poor maternal and neonatal outcomes. METHODS: A 7-day, international, prospective, observational cohort study was done in patients having caesarean delivery in 183 hospitals across 22 countries in Africa. The inclusion criteria were all consecutive patients (aged ≥18 years) admitted to participating centres having elective and non-elective caesarean delivery during the 7-day study cohort period. To ensure a representative sample, each hospital had to provide data for 90% of the eligible patients during the recruitment week. The primary outcome was in-hospital maternal mortality and complications, which were assessed by local investigators. The study was registered on the South African National Health Research Database, number KZ_2015RP7_22, and on ClinicalTrials.gov, number NCT03044899. FINDINGS: Between February, 2016, and May, 2016, 3792 patients were recruited from hospitals across Africa. 3685 were included in the postoperative complications analysis (107 missing data) and 3684 were included in the maternal mortality analysis (108 missing data). These hospitals had a combined number of specialist surgeons, obstetricians, and anaesthetists totalling 0·7 per 100 000 population (IQR 0·2-2·0). Maternal mortality was 20 (0·5%) of 3684 patients (95% CI 0·3-0·8). Complications occurred in 633 (17·4%) of 3636 mothers (16·2-18·6), which were predominantly severe intraoperative and postoperative bleeding (136 [3·8%] of 3612 mothers). Maternal mortality was independently associated with a preoperative presentation of placenta praevia, placental abruption, ruptured uterus, antepartum haemorrhage (odds ratio 4·47 [95% CI 1·46-13·65]), and perioperative severe obstetric haemorrhage (5·87 [1·99-17·34]) or anaesthesia complications (11·47 (1·20-109·20]). Neonatal mortality was 153 (4·4%) of 3506 infants (95% CI 3·7-5·0). INTERPRETATION: Maternal mortality after caesarean delivery in Africa is 50 times higher than that of high-income countries and is driven by peripartum haemorrhage and anaesthesia complications. Neonatal mortality is double the global average. Early identification and appropriate management of mothers at risk of peripartum haemorrhage might improve maternal and neonatal outcomes in Africa. FUNDING: Medical Research Council of South Africa.Medical Research Council of South Africa