Adaptive Impact Factor Research Concerning Effectiveness of the Introduction and use of Digital Twins for Oil and Gas Deposits

In recent years, there have been significant changes in the conditions of oil production leading to an increase in its cost and wasteful use of resources. This necessitates the search for a system of adaptive factors that can adapt to environmental changes, affect the cost reduction and increase in the efficiency of oil and gas fields. Studies show that this problem needs to be solved on the basis of the creation of digital oil or gas fields being digital counterparts of existing enterprises, which allow preserving nature and use resources economically due to the existing field development at a new qualitative level. However, the transformation of existing fields through their transformation into digital oil or gas fields requires serious justification, and above all, from a financial and economic points of view. At the same time, one should in no case ignore the natural factor contributing to saving, restoring the used oil and gas resources and preserving the external space being the human environment. The purpose of this study is to develop recommendations for assessing the economic efficiency of the implementation of the project concerning a digital oil or gas field being a digital twin of oil or gas enterprise, and their use in practice. Such an assessment will be carried out based on the analysis of the ratio between capital investments and operating costs necessary to create a digital oil or gas field, as well as by comparing the expected costs and benefits derived from its use

Hydrogen-free reductive amination using iron pentacarbonyl as a reducing agent

We developed solvent-free reductive amination without an external hydrogen source using iron pentacarbonyl as a reducing agent. Neither a catalyst nor any other additives were employed. Various types of substrates are suitable for the reaction, including those with low reactivity, e.g. benzophenone. Among others, the protocol tolerates bromo-, cyano-, benzyloxy-, pyrimidyl and styryl moieties. © 2017 The Royal Society of Chemistry

Hydrogen-free reductive amination using iron pentacarbonyl as a reducing agent

We developed solvent-free reductive amination without an external hydrogen source using iron pentacarbonyl as a reducing agent. Neither a catalyst nor any other additives were employed. Various types of substrates are suitable for the reaction, including those with low reactivity, e.g. benzophenone. Among others, the protocol tolerates bromo-, cyano-, benzyloxy-, pyrimidyl and styryl moieties. © 2017 The Royal Society of Chemistry

Dichotomy of reductive addition of amines to cyclopropyl ketones vs pyrrolidine synthesis

An interesting catalytic dichotomy was discovered: switching between simple ligand-free catalysts leads to fundamentally different outcomes of reductive reaction between amines and α-carbonylcyclopropanes. Whereas a rhodium catalyst leads to the traditional reductive amination product, ruthenium catalysis enables a novel reaction of pyrrolidine synthesis via ring expansion. The protocols do not require an external hydrogen source and employ carbon monoxide as a deoxygenative agent. The developed methodologies are perfectly compatible with a number of synthetically important functionalities such as ester, carboxyl, bromo, and Cbz moieties. © 2016 American Chemical Society

Reductive Amination in the Synthesis of Pharmaceuticals

Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry owing to its synthetic merits and the ubiquitous presence of amines among biologically active compounds. It is one of the key approaches to C-N bond construction due to its operational easiness and a wide toolbox of protocols. Recent studies show that at least a quarter of C-N bond-forming reactions in the pharmaceutical industry are performed via reductive amination. This Review concisely compiles information on 71 medical substances that are synthesized by reductive amination. Compounds are grouped according to the principle of action, which includes drugs affecting the central nervous system, drugs affecting the cardiovascular system, anticancer drugs, antibiotics, antiviral and antifungal medicines, drugs affecting the urinary system, drugs affecting the respiratory system, antidiabetic medications, drugs affecting the gastrointestinal tract, and drugs regulating metabolic processes. A general synthetic scheme is provided for each compound, and the description is focused on reductive amination steps. The green chemistry metric of reaction mass efficiency was calculated for all reactions. © 2019 American Chemical Society

Dichotomy of reductive addition of amines to cyclopropyl ketones vs pyrrolidine synthesis

An interesting catalytic dichotomy was discovered: switching between simple ligand-free catalysts leads to fundamentally different outcomes of reductive reaction between amines and α-carbonylcyclopropanes. Whereas a rhodium catalyst leads to the traditional reductive amination product, ruthenium catalysis enables a novel reaction of pyrrolidine synthesis via ring expansion. The protocols do not require an external hydrogen source and employ carbon monoxide as a deoxygenative agent. The developed methodologies are perfectly compatible with a number of synthetically important functionalities such as ester, carboxyl, bromo, and Cbz moieties. © 2016 American Chemical Society

New approaches for the reductive formation of the C-N bond

This work was supported by the Grant for Young Scientists (No. MK-520.2017.3) and RUDN University Program “5-100”

Hitchhiker's Guide to Reductive Amination

A comparative study of various widely used methods of reductive amination is reported. Specifically, such reducing agents as H 2, Pd/C, hydride reagents [NaBH 4, NaBH 3 CN, NaBH(OAc) 3 ], and CO/Rh 2 (OAc) 4 system were considered. For understanding the selectivity and activity of the reducing agents reviewed herein, different classes of starting materials were tested, including aliphatic and aromatic amines, as well as aliphatic and aromatic aldehydes and ketones. Most important advantages and drawbacks of the methods, such as selectivity of the target amine formation and toxicity of the reducing agents were compared. Methods were also considered from the viewpoint of green chemistry. © Georg Thieme Verlag Stuttgart · New York-Synthesis

Alkyl formates as reagents for reductive amination of carbonyl compounds

Alkyl formates in the presence of basic additives can serve as a reagent in the direct reductive amination of carbonyl compounds. The developed procedure can be applied to various aldehydes and ketones with electron donating and electron withdrawing groups. © 201

Reductive amination catalyzed by iridium complexes using carbon monoxide as a reducing agent

Development of novel, sustainable catalytic methodologies to provide access to amines represents a goal of fundamental importance. Herein we describe a systematic study for the construction of a variety of amines catalyzed by a well-defined homogeneous iridium complex using carbon monoxide as a reducing agent. The methodology was shown to be compatible with functional groups prone to reduction by hydrogen or complex hydrides. © The Royal Society of Chemistry 2017